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Ameliorative Effects of Rhamnetin against Polystyrene Microplastics-Induced Nephrotoxicity in Rats
Summary
Researchers investigated whether the flavonoid rhamnetin could protect against kidney damage caused by polystyrene microplastics in rats. The study found that microplastic exposure significantly increased oxidative stress and inflammatory markers while reducing antioxidant enzyme activity, but co-treatment with rhamnetin restored kidney parameters and mitigated the damage.
The present study was intended to ascertain the attenuative role of rhamnetin (RHM) against polystyrene microplastics (PS-MPs) prompted nephrotoxicity in rats.24 male albino rats (6-8 weeks old) were arbitrarily separated into 4 groups viz.control, PS-MPS (0.01mg/kg) treated group, RHM+PS-MPs (0.01mg/kg + 50mg/kg) co-treated group and only RHM (50mg/kg) treated group.The experiment was executed for 30 days.At the last day, all the rats were slaughtered to analyze the various kidney parameters.Our findings demonstrated that PS-MPs exposure significantly lowered the enzymatic antioxidant activities (CAT, GPx, GSR, SOD, GST & GSH), while it augmented the level of oxidative stress markers (ROS and MDA).PS-MPs administration significantly up-regulated the level of KIM-1, NGAL, serum urea & creatinine, whereas reduced the creatinine clearance.Additionally, PS-MPs significantly elevated the inflammatory markers level such as TNF-α (tumor necrosis factor alpha), IL-1β (Interleukin-1 beta), NF-κB (nuclear factor kappa-B), IL-6 (Interleukin-6) and COX-2 (cyclooxygenase-2) activity along with histological abnormalities.However, RHM co-treatment with PS-MPs exhibited protective effect against PS-MPs provoked nephrotoxicity and restored all the anomalies.These finding s have proposed that RHM is a potent flavone that can mitigate the kidney damages caused by PS-MPs.