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Ameliorative Effects of Rhamnetin against Polystyrene Microplastics-Induced Nephrotoxicity in Rats
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Researchers investigated whether the flavonoid rhamnetin could protect against kidney damage caused by polystyrene microplastics in rats. The study found that microplastic exposure significantly increased oxidative stress and inflammatory markers while reducing antioxidant enzyme activity, but co-treatment with rhamnetin restored kidney parameters and mitigated the damage.
The present study was intended to ascertain the attenuative role of rhamnetin (RHM) against polystyrene microplastics (PS-MPs) prompted nephrotoxicity in rats.24 male albino rats (6-8 weeks old) were arbitrarily separated into 4 groups viz.control, PS-MPS (0.01mg/kg) treated group, RHM+PS-MPs (0.01mg/kg + 50mg/kg) co-treated group and only RHM (50mg/kg) treated group.The experiment was executed for 30 days.At the last day, all the rats were slaughtered to analyze the various kidney parameters.Our findings demonstrated that PS-MPs exposure significantly lowered the enzymatic antioxidant activities (CAT, GPx, GSR, SOD, GST & GSH), while it augmented the level of oxidative stress markers (ROS and MDA).PS-MPs administration significantly up-regulated the level of KIM-1, NGAL, serum urea & creatinine, whereas reduced the creatinine clearance.Additionally, PS-MPs significantly elevated the inflammatory markers level such as TNF-α (tumor necrosis factor alpha), IL-1β (Interleukin-1 beta), NF-κB (nuclear factor kappa-B), IL-6 (Interleukin-6) and COX-2 (cyclooxygenase-2) activity along with histological abnormalities.However, RHM co-treatment with PS-MPs exhibited protective effect against PS-MPs provoked nephrotoxicity and restored all the anomalies.These finding s have proposed that RHM is a potent flavone that can mitigate the kidney damages caused by PS-MPs.
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Evaluation of Possible Ameliorative Role of Robinetin to Counteract Polystyrene Microplastics Instigated Renal Toxicity in Rats
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Twenty-four rats were given polystyrene microplastics, robinetin, both or neither. Microplastics lowered antioxidant enzyme activity in the kidney and raised markers of kidney injury, inflammation and cell death. Rats that also received robinetin, a plant flavonoid, had values closer to those of the control group.
Rhamnetin abrogates polystyrene microplastics prompted hepatic damage by regulating Nrf-2/Keap-1 pathway
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Researchers investigated whether rhamnetin, a natural flavonoid, could protect against liver damage induced by polystyrene microplastics in rats administered 0.01 mg/kg PS-MPs for the experimental period. They found that PS-MPs suppressed the Nrf-2/Keap-1 antioxidant pathway, reduced activities of SOD, CAT, GPx, GST, and HO-1 enzymes, elevated ALT, AST, and ALP liver injury markers, and increased apoptotic signaling, while co-administration of 50 mg/kg rhamnetin mitigated all these effects through hepatoprotective, anti-inflammatory, and antioxidant mechanisms.
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Researchers found that ginkgetin, a natural flavonoid, significantly reduced polystyrene microplastic-induced kidney damage in rats by restoring antioxidant enzyme activity and reducing oxidative stress and inflammation markers.
Rhamnetin alleviates polystyrene microplastics-induced testicular damage by restoring biochemical, steroidogenic, hormonal, apoptotic, inflammatory, spermatogenic and histological profile in male albino rats
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Researchers studied whether the plant compound rhamnetin could protect against testicular damage caused by polystyrene microplastics in rats. Microplastic exposure caused significant harm to sperm quality, hormone levels, and testicular tissue through oxidative stress and inflammation. Co-treatment with rhamnetin restored many of these markers, suggesting it may help counteract some of the reproductive harm associated with microplastic exposure.
Palliative potential of robinetin to avert polystyrene microplastics instigated pulmonary toxicity in rats
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Researchers investigated whether the flavonoid compound robinetin could protect against lung damage caused by polystyrene microplastic exposure in rats. They found that robinetin supplementation reduced oxidative stress markers and inflammatory responses in lung tissue that had been damaged by microplastic ingestion. The study suggests that certain natural compounds may help mitigate some of the harmful effects of microplastic exposure on respiratory tissues.
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