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Reno-protective potential of poncirin against polyethylene microplastics instigated kidney damage in rats via regulating Nrf-2/Keap-1 pathway
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In a rat study, daily exposure to polyethylene microplastics caused kidney damage — elevated creatinine, urea, and injury biomarkers — while a natural plant compound called poncirin partially reversed this damage by activating the Nrf-2/Keap-1 antioxidant defense pathway. While the doses used were high and results need human validation, the study adds to growing evidence that microplastics can harm the kidneys and that dietary antioxidants may offer some protection.
Polyethylene microplastics (PEMPs) are noxious environmental pollutants that are documented to cause organ damage including the kidneys. Poncirin (PON) is a naturally occurring flavonoid which demonstrates a wide range of pharmacological properties. This experiment was conducted to evaluate the palliative potential of PON against PEMPs by examining a range of biochemical and physiological parameters. Twenty-four male albino rats were randomly apportioned into four distinct groups including the control, PEMPs (1.5 mgkg −1 ), PEMPs (1.5 mgkg −1 ) + PON (20 mgkg −1 ) & only PON (20 mgkg −1 ). Our results displayed that PEMPs intoxication escalated the levels of urea, KIM-1, creatinine & NGAL while demising the creatinine clearance level. Besides reduction in the activities of GPx, GST, HO-1, CAT, GSR & upsurge in the levels of MDA and ROS were detected in PEMPs group. Conversely, the levels of inflammatory markers including COX-2, IL-1β, NF-kB and TNF-α were augmented following the PEMPs intoxication. Besides, the results of current research demonstrated that levels of Bax & caspase-3 were more than normal whereas the Bcl-2 expression was lowered from its standard value due to PEMPs provision. However, PON treatment significantly restored the PEMPs-induced biochemical impairments. Therefore, PON could be used as a therapeutic compound to ameliorate PEMPs-induced kidney impairments in rats, possibly due to its tremendous pharmacotherapeutic potential.
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