Papers

61,005 results
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Article Tier 2

Novel Technologies for Polyhydroxyalkanoates (PHA) Production

This review examines novel production technologies for polyhydroxyalkanoates, highlighting how the global problem of plastic and microplastic pollution has intensified interest in developing scalable, eco-friendly bioplastic alternatives over more than four decades of PHA research.

2025 Apple Academic Press eBooks
Article Tier 2

Advances in Polyhydroxyalkanoate (PHA) Production, Volume 3

This review synthesizes advances in polyhydroxyalkanoate (PHA) biopolyester production as a family of biodegradable alternatives to conventional plastics, addressing growing public concern about plastic waste and microplastic formation by examining the latest research on PHA synthesis from fossil-free feedstocks.

2022 9 citations
Article Tier 2

Current trends in the production of biodegradable bioplastics: The case of polyhydroxyalkanoates

This review evaluates the state of polyhydroxyalkanoate (PHA) bioplastic production, comparing microbiological, enzymatic, and chemical manufacturing approaches for their potential to replace petroleum-based plastics. While PHAs are naturally biodegradable and mechanically versatile, cost and scalability remain major barriers to commercial adoption.

2020 Biotechnology Advances 130 citations
Article Tier 2

Metabolic Process and Types of Carbon Source leads to Desired Polyhydroxyalkanoate Properties

This review examines how different carbon sources and metabolic pathways influence the biosynthetic production of polyhydroxyalkanoates (PHAs), analyzing how carbon source selection and organism choice determine whether homo- or copolymers are produced and shape the resulting physical and chemical properties of these biodegradable plastics.

2025 Current Applied Science and Technology
Article Tier 2

PHA-Based Bioplastic: a Potential Alternative to Address Microplastic Pollution

This review examines polyhydroxyalkanoate (PHA)-based bioplastics as biodegradable alternatives to petroleum-derived plastics, highlighting their potential to reduce microplastic pollution while discussing challenges in scaling production and improving material properties.

2022 Water Air & Soil Pollution 172 citations
Article Tier 2

Bacterial Production of Hydroxyalkanoates (PHA)

This review examines bacterial production of polyhydroxyalkanoates (PHA) as a biodegradable alternative to petroleum-based plastics, covering fermentation processes, scaling to industrial levels, and future trends, while noting that higher production costs currently prevent PHAs from competing commercially with conventional plastics.

2016 Universal Journal of Microbiology Research 32 citations
Article Tier 2

Production of polyhydroxyalkanoate (PHA) biopolymer from crop residue using bacteria as an alternative to plastics: a review

This review examines how PHA, a biodegradable plastic made from crop waste using bacteria, could serve as a sustainable alternative to conventional plastics. While PHA breaks down naturally unlike traditional plastics that fragment into microplastics, challenges remain in making it heat-stable and cost-competitive enough for widespread industrial use.

2025 RSC Advances 22 citations
Article Tier 2

Polyhydroxyalkanoates biosynthesis, resulting polymer structures, and plasticization

This review examines polyhydroxyalkanoates (PHAs), a class of biodegradable biopolymers synthesized by microorganisms, discussing strategies including plasticizers and monomer inclusion to overcome the brittleness and processing challenges of the most common PHA, poly(3-hydroxybutyrate).

2024
Article Tier 2

Polyhydroxyalkanoate (PHA) Biopolyesters - Emerging and Major Products of Industrial Biotechnology

This review examined polyhydroxyalkanoate biopolyesters as industrially produced biodegradable plastics, covering their microbial biosynthesis, material properties, and commercial applications as sustainable alternatives to conventional petroleum-based plastics.

2022 The EuroBiotech Journal 23 citations
Article Tier 2

Exploring the Feasibility of Cell-Free Synthesis as a Platform for Polyhydroxyalkanoate (PHA) Production: Opportunities and Challenges

This paper is not about microplastics; it reviews cell-free synthesis as a platform for producing polyhydroxyalkanoate (PHA) bioplastics as alternatives to petroleum-based plastics.

2023 Polymers 11 citations
Article Tier 2

Strategies for Biosynthesis of C1 Gas-derived Polyhydroxyalkanoates: A review

Researchers reviewed strategies for producing polyhydroxyalkanoates (PHAs) — biodegradable bioplastics — from one-carbon gases like CO2, CO, and methane using autotrophic and methanotrophic microbes, highlighting fermentation and metabolic engineering approaches as cost-effective alternatives to conventional carbon-source-dependent PHA production.

2021 Bioresource Technology 35 citations
Article Tier 2

A Review on Biological Synthesis of the Biodegradable Polymers Polyhydroxyalkanoates and the Development of Multiple Applications

This review covers the biological production of polyhydroxyalkanoates, a family of biodegradable bioplastics that bacteria naturally produce from waste carbon sources. Researchers found that these biopolymers have properties similar to conventional plastics like polypropylene but can fully biodegrade, making them a promising alternative to petroleum-based plastics. The study emphasizes that scaling up production and establishing proper end-of-life management are critical steps for PHAs to compete with conventional plastics and help reduce microplastic pollution.

2022 Catalysts 169 citations
Article Tier 2

Polyhydroxyalkanoates (PHAs) – Production, Properties, and Biodegradation

This review covers polyhydroxyalkanoates (PHAs), a class of microbially produced biopolyesters, discussing raw material innovation, microbial producer strains, bioengineering approaches for improved yields, and end-of-life biodegradation options. PHAs are presented as a genuinely circular plastic alternative due to their renewable production, biodegradability, and compatibility with existing plastic applications including food packaging.

2022 15 citations
Article Tier 2

Advances in Polyhydroxyalkanoate (PHA) Production, Volume 2

This editorial introduces a second special journal issue on polyhydroxyalkanoate (PHA) production — a class of biodegradable plastics produced by microorganisms — covering recent advances in bioprocessing and applications. PHAs are being developed as biodegradable alternatives to petroleum-based plastics to reduce microplastic pollution.

2020 Bioengineering 26 citations
Article Tier 2

Biosynthesis of Polyhydroxyalkanoates (PHAs) by the Valorization of Biomass and Synthetic Waste

This paper explores the production of polyhydroxyalkanoates (PHAs), biodegradable microbial polymers, from biomass and waste feedstocks as a sustainable alternative to conventional synthetic plastics. PHAs can be naturally synthesized by bacteria, offering a pathway to biodegradable plastics that do not persist as microplastic pollution.

2020 Molecules 47 citations
Article Tier 2

Paving the way for biobased materials : a roadmap for the market introduction of PHAs

This roadmap paper examines barriers to large-scale commercial production of PHA biopolymers, which are biodegradable alternatives to petroleum-based plastics. Scaling up PHA production is essential for offering plastic manufacturers sustainable alternatives that would not persist as microplastics in the environment.

2022 4 citations
Article Tier 2

Advances in Polyhydroxyalkanoate (PHA) Production, Volume 3

This review synthesizes 15 research contributions to the third special issue on polyhydroxyalkanoate (PHA) biopolyesters, covering advances in inexpensive feedstocks from agricultural waste, CO2-based biosynthesis by cyanobacteria and engineered bacteria, extremophile-derived PHAs, and novel processing strategies aimed at making PHA a viable sustainable alternative to fossil-based plastics.

2022 Bioengineering 12 citations
Article Tier 2

Insightful Advancement and Opportunities for Microbial Bioplastic Production

This review surveys advances in microbial production of polyhydroxyalkanoates (PHAs) and other bioplastics, highlighting fermentation optimization, feedstock diversification, and genetic engineering strategies that could make microbially-derived bioplastics economically competitive with petroleum-based plastics.

2022 Frontiers in Microbiology 39 citations
Article Tier 2

Scalable Step-by-Step Approach of Sustainable Bioplastic Production from Food Waste

Researchers developed a scalable step-by-step method for producing polyhydroxyalkanoates (PHAs) bioplastics from food waste, addressing both the microplastic crisis and food waste challenges by demonstrating that food waste feedstocks can enable sustainable PHA production as a fully biodegradable alternative to petroleum-based plastics.

2025 Journal of Visualized Experiments
Article Tier 2

The synthesis of polyhydroxyalkanoates from low carbon wastewater under anaerobic-microaerobic process: effects of pH and nitrogen and phosphorus limitation

Researchers optimized conditions for producing polyhydroxyalkanoates (PHAs) — biodegradable bioplastics — from wastewater using bacteria under anaerobic-microaerobic conditions. Controlling pH and nutrient levels significantly improved PHA production yield. This work advances the development of sustainable plastic alternatives made from waste materials.

2021 Environmental Engineering Research 13 citations
Article Tier 2

Advanced approaches to produce polyhydroxyalkanoate (PHA) biopolyesters in a sustainable and economic fashion

This review examines strategies to reduce polyhydroxyalkanoate (PHA) bioplastic production costs by replacing expensive first-generation feedstocks (glucose, starch) with carbon-rich industrial waste streams as second-generation substrates. Researchers describe results from the EU-funded ANIMPOL and WHEYPOL projects, which demonstrated PHA production from animal processing and whey waste residues, improving economic viability and sustainability.

2018 The EuroBiotech Journal 104 citations
Article Tier 2

Polyhydroxyalkanoate (PHA) Bio-polyesters – Circular Materials for Sustainable Development and Growth

This review examines polyhydroxyalkanoate (PHA) biopolymers as circular carbon materials produced from renewable feedstocks and biodegradable across diverse environments, arguing that PHAs offer a more genuine solution to microplastic pollution than conventional bioplastics that require industrial composting.

2023 Chemical and Biochemical Engineering Quarterly 21 citations
Article Tier 2

Advancements in genetic engineering for enhanced Polyhydroxyalkanoates (PHA) production: a comprehensive review of metabolic pathway manipulation and gene deletion strategies

This review examines genetic engineering strategies for boosting production of polyhydroxyalkanoates, which are biodegradable bioplastics produced by bacteria. Researchers describe how modifying metabolic pathways and deleting competing genes can significantly increase bioplastic yields. The technology is relevant to the microplastics problem because scaling up biodegradable plastic alternatives could help reduce the accumulation of persistent conventional plastics in the environment.

2025 Bioengineered 17 citations
Article Tier 2

What Is New in the Field of Industrial Wastes Conversion into Polyhydroxyalkanoates by Bacteria?

This review covers recent advances in using bacteria to convert industrial food waste into polyhydroxyalkanoates (PHAs), a type of biodegradable bioplastic. Using industrial waste as feedstock for bioplastic production could reduce both plastic pollution and food industry waste simultaneously.

2021 Polymers 24 citations