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Exploring the Feasibility of Cell-Free Synthesis as a Platform for Polyhydroxyalkanoate (PHA) Production: Opportunities and Challenges
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This paper is not about microplastics; it reviews cell-free synthesis as a platform for producing polyhydroxyalkanoate (PHA) bioplastics as alternatives to petroleum-based plastics.
The extensive utilization of traditional petroleum-based plastics has resulted in significant damage to the natural environment and ecological systems, highlighting the urgent need for sustainable alternatives. Polyhydroxyalkanoates (PHAs) have emerged as promising bioplastics that can compete with petroleum-based plastics. However, their production technology currently faces several challenges, primarily focused on high costs. Cell-free biotechnologies have shown significant potential for PHA production; however, despite recent progress, several challenges still need to be overcome. In this review, we focus on the status of cell-free PHA synthesis and compare it with microbial cell-based PHA synthesis in terms of advantages and drawbacks. Finally, we present prospects for the development of cell-free PHA synthesis.
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PHA-Based Bioplastic: a Potential Alternative to Address Microplastic Pollution
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This review examines polyhydroxyalkanoate (PHA)-based bioplastics as biodegradable alternatives to petroleum-derived plastics, highlighting their potential to reduce microplastic pollution while discussing challenges in scaling production and improving material properties.
Advances in Polyhydroxyalkanoate (PHA) Production, Volume 3
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This review synthesizes advances in polyhydroxyalkanoate (PHA) biopolyester production as a family of biodegradable alternatives to conventional plastics, addressing growing public concern about plastic waste and microplastic formation by examining the latest research on PHA synthesis from fossil-free feedstocks.
Efficient biosynthesis and recovery of polyhydroxyalkanoate
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This review examines the biosynthesis and recovery of polyhydroxyalkanoate (PHA), a microbially-produced biodegradable bioplastic that could replace petrochemical plastics and reduce microplastic pollution. The main barrier to commercialization is production cost, and the paper discusses strategies for making PHA economically viable at scale.
Novel Technologies for Polyhydroxyalkanoates (PHA) Production
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This review examines novel production technologies for polyhydroxyalkanoates, highlighting how the global problem of plastic and microplastic pollution has intensified interest in developing scalable, eco-friendly bioplastic alternatives over more than four decades of PHA research.
Bacterial Production of Hydroxyalkanoates (PHA)
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This review examines bacterial production of polyhydroxyalkanoates (PHA) as a biodegradable alternative to petroleum-based plastics, covering fermentation processes, scaling to industrial levels, and future trends, while noting that higher production costs currently prevent PHAs from competing commercially with conventional plastics.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.