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Strategies for Biosynthesis of C1 Gas-derived Polyhydroxyalkanoates: A review
Summary
Researchers reviewed strategies for producing polyhydroxyalkanoates (PHAs) — biodegradable bioplastics — from one-carbon gases like CO2, CO, and methane using autotrophic and methanotrophic microbes, highlighting fermentation and metabolic engineering approaches as cost-effective alternatives to conventional carbon-source-dependent PHA production.
Biosynthesis of polyhydroxyalkanoates (PHAs) from C1 gases is highly desirable in solving problems such as climate change and microplastic pollution. PHAs are biopolymers synthesized in microbial cells and can be used as alternatives to petroleum-based plastics because of their biodegradability. Because 50% of the cost of PHA production is due to organic carbon sources and salts, the utilization of costless C1 gases as carbon sources is expected to be a promising approach for PHA production. In this review, strategies for PHA production using C1 gases through fermentation and metabolic engineering are discussed. In particular, autotrophs, acetogens, and methanotrophs are strains that can produce PHA from CO, CO, and CH. In addition, integrated bioprocesses for the efficient utilization of C1 gases are introduced. Biorefinery processes from C1 gas into bioplastics are prospective strategies with promising potential and feasibility to alleviate environmental issues.