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61,005 resultsShowing papers similar to The Threat of Micro-/Nanoplastics to Male Fertility: A Review of the Data and the Importance of Future Research
ClearUnravelling the potential mechanisms of nano- and microplastic toxicity to the male reproductive system: A systematic review
This systematic review found that micro- and nanoplastics accumulate in the testes and epididymis in rodent models, disrupting the blood-testis barrier, increasing germ cell death, reducing sperm motility, and causing hormone imbalance through oxidative stress and inflammation. Smaller nanoplastics penetrate tissues more readily for molecular disruption, while larger microplastics cause greater structural damage.
Microplastics and male reproductive system: A comprehensive review based on cellular and molecular effects
This comprehensive review examines how microplastics affect the male reproductive system at cellular and molecular levels, drawing on studies from multiple scientific databases. Researchers found that microplastics can damage testicular structure and function, impair spermatogenesis, and disrupt sperm parameters through mechanisms including oxidative stress, inflammation, and activation of cell death pathways. The review highlights that microplastics reduce ATP production and trigger signaling cascades that may contribute to male fertility problems.
Research Progress in Reproductive Toxicity of Micro- and Nanoplastics on Males and Its Mechanisms
This review summarized research on the reproductive toxicity of micro- and nanoplastics (MNPs) in males, finding that MNPs accumulate in reproductive organs and cause toxicity through oxidative stress, hormonal disruption, and DNA damage, with implications for both animal and human reproductive health.
Micro- and nanoplastics in human male reproduction: Immune disruption, blood–testis barrier, and clinic-ready biomarkers
This review synthesizes evidence that micro- and nanoplastics have been detected in human testes and semen, with experimental models showing they trigger oxidative stress, NLRP3 inflammasome activation, and disruption of blood-testis barrier tight-junction proteins, collectively impairing sperm production and quality.
Microplastics and impaired male reproductive health—exploring biological pathways of harm: a narrative review
This narrative review summarizes the evidence that microplastics may harm male reproductive health through oxidative stress, hormone disruption, inflammation, and direct damage to reproductive cells. While animal studies show concerning effects on sperm quality, testicular function, and fertility, human studies are still lacking. The review calls for urgent research on microplastic impacts on human male fertility and for policies to reduce microplastic exposure.
Adverse effects of microplastics and nanoplastics on the reproductive system: A comprehensive review of fertility and potential harmful interactions
This review summarizes how microplastics and nanoplastics can harm both male and female reproductive systems by disrupting hormone signaling, damaging sperm and egg cells, and causing inflammation in reproductive tissues. Smaller nanoplastics are especially concerning because they can cross biological barriers more easily and reach the testes and ovaries. With global infertility rates rising, the authors highlight environmental plastic exposure as a factor that deserves more research attention.
Effects of micro(nano)plastics on the reproductive system: A review
This review summarizes research on how micro and nanoplastics affect the reproductive system in both animal studies and cell experiments. Evidence indicates these particles can cross biological barriers, accumulate in reproductive organs, and disrupt hormones, egg development, and sperm quality. While human studies are still limited, the animal data suggests microplastic exposure may be a meaningful concern for reproductive health.
Toxicological effects of micro/nano-plastics on human reproductive health: A review
This review summarizes research on how micro- and nanoplastics affect human reproductive health in both men and women. Evidence from animal and lab studies shows that these particles can accumulate in reproductive organs, disrupt hormones, damage eggs and sperm, and cause inflammation and oxidative stress. While human studies are still limited, the growing body of evidence suggests that microplastic exposure is a potential threat to fertility that warrants further investigation.
The hidden threat: Unraveling the impact of microplastics on reproductive health
This review summarizes how microplastics disrupt the reproductive system in both males and females by interfering with hormone signaling, damaging the blood-testis barrier, impairing sperm production, and causing problems in the ovaries and uterus. The authors also note that microplastic exposure may affect offspring development, including their future reproductive capacity and metabolism.
Reproductive toxicity and related mechanisms of micro(nano)plastics in terrestrial mammals: Review of current evidence.
This review of terrestrial mammal studies found that micro- and nanoplastics induce reproductive toxicity through oxidative stress, inflammation, endocrine disruption, and DNA damage, affecting both male and female fertility. In males, effects include blood-testis barrier disruption and impaired spermatogenesis, while females show compromised oocyte maturation, ovarian fibrosis, and diminished ovarian reserve, with particles also capable of crossing the maternal-fetal interface.
Effects of nano and microplastics on the reproduction system: In vitro and in vivo studies review
This review summarizes both lab and animal studies on how micro and nanoplastics affect the reproductive system in males and females. Evidence shows that microplastics can reduce sperm quality, damage ovaries, disrupt hormone levels, and even cross the placenta during pregnancy. The findings raise significant concerns about how widespread microplastic exposure might contribute to fertility problems and reproductive health issues in humans.
The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge
Researchers administered polystyrene nanoplastics orally to male rats for five weeks and found significant reductions in testosterone, LH, and FSH levels, sperm DNA damage, altered testicular gene expression, and dose-dependent histological lesions, indicating that nanoplastic exposure disrupts the hormonal axis governing male reproductive function.
"Unseen Dangers: The Effects of Micro- and Nanoplastics on Human Reproductive Health - A Narrative Review"
This review examines the effects of micro- and nanoplastics on human reproductive health, covering evidence from in vitro, animal, and epidemiological studies showing that plastic particles can disrupt hormone signaling, sperm function, ovarian development, and placental integrity.
Male infertility and its link to microplastics: A sterile future
This review examines the link between microplastic exposure and male infertility, summarizing evidence that microplastics and their chemical additives disrupt reproductive hormones, sperm quality, and testicular function in animal models and human studies.
Microplastics and human fertility: A comprehensive review of their presence in human samples and reproductive implication
This review examines the growing evidence linking microplastic and nanoplastic exposure to potential effects on human fertility. Researchers noted that these tiny plastic particles have been detected in blood, placenta, and seminal fluid, suggesting continuous systemic exposure and the ability to cross key biological barriers. Animal studies indicate that microplastics may affect reproductive health through oxidative stress, hormonal disruption, and tissue damage, though more standardized human research is needed.
Unraveling the threat: Microplastics and nano-plastics' impact on reproductive viability across ecosystems
This review summarizes research on how microplastics and nanoplastics affect reproduction across many species, from aquatic invertebrates to mammals including humans. In males, exposure leads to testicular damage, lower sperm quality, and hormone disruption; in females, it causes ovarian and uterine problems, inflammation, and reduced fertility. The evidence also shows these reproductive harms can be passed to offspring, raising serious concerns about long-term effects on human fertility.
A meta-analysis-based adverse outcome pathway for the male reproductive toxicity induced by microplastics and nanoplastics in mammals
This meta-analysis of 39 studies mapped the adverse outcome pathway for microplastic and nanoplastic-induced male reproductive toxicity in mammals. Increased reactive oxygen species triggers a cascade of cellular damage including mitochondrial dysfunction, sperm DNA damage, and disrupted hormone signaling, ultimately leading to reduced sperm quality, impaired spermatogenesis, and decreased testosterone levels.
Micro- and Nanoplastics as Disruptors of the Endocrine System—A Review of the Threats and Consequences Associated with Plastic Exposure
This review summarizes how micro- and nanoplastics carry endocrine-disrupting chemicals that interfere with hormones controlling reproduction, thyroid function, metabolism, and brain development. The reproductive system is especially vulnerable, with studies showing that plastic particle exposure can cause oxidative stress, cell death, and infertility, raising serious concerns given how widespread these particles are in food and the environment.
The male reproductive toxicity after nanoplastics and microplastics exposure: Sperm quality and changes of different cells in testis
A mouse study compared the reproductive toxicity of nanoplastics versus microplastics and found that both damaged the testes after 12 weeks of exposure, but microplastics caused more severe harm in some measures. The plastics disrupted sperm production, caused inflammation and oxidative stress, and damaged the cells that support sperm development. These findings suggest that plastic particle exposure could contribute to male fertility problems, with different particle sizes affecting reproductive health through different biological pathways.
Exploring the impact of polyethylene terephthalate nanoplastics on male reproductive health: Insights from a mouse model study
Researchers investigated the impact of polyethylene terephthalate nanoplastics on male reproductive health, examining whether nanoplastic exposure contributes to infertility by affecting sperm function, hormone levels, or testicular tissue. Results showed PET nanoplastics impaired reproductive endpoints in the male reproductive system, adding to growing concern about plastic particle effects on fertility.
Microplastics May Be a Significant Cause of Male Infertility
This review examines the potential link between microplastic exposure and the decline in male fertility observed over recent decades. Researchers reviewed evidence showing that microplastics can accumulate in reproductive tissues and may damage sperm quality through oxidative stress, hormonal disruption, and inflammatory responses. The study suggests that microplastics deserve serious attention as a possible contributing factor to rising male infertility rates.
Exploring the impact of polyethylene terephthalate nanoplastics on male reproductive health: Insights from a mouse model study
Researchers investigated the effects of PET nanoplastics on male reproductive function, examining sperm quality, hormone levels, and testicular tissue in animal models. PET nanoplastic exposure reduced sperm motility and caused histological changes in testicular tissue, suggesting a potential role in male infertility.
Reproductive and developmental implications of micro- and nanoplastic internalization: Recent advances and perspectives
This systematic review documented the detection of micro- and nanoplastics in human semen, placenta, and ovarian follicular fluid, and found evidence linking exposure to impaired sperm quality, disrupted ovarian function, and adverse pregnancy outcomes. In animal models, MNPs caused developmental toxicity and transgenerational effects, with oxidative stress, inflammation, and epigenetic modification identified as key mechanisms.
Reproductive toxicity of micro- and nanoplastics
This review summarizes existing research on how micro- and nanoplastics harm reproduction across many species, from marine invertebrates to mammals. The particles can cause oxidative stress and hormone disruption, leading to reduced fertility, abnormal embryo development, and toxic effects that pass to offspring. The findings raise concerns that human reproductive health could be similarly affected given our increasing exposure to these particles.