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Article Tier 2 Human Health Effects Reproductive & Development Sign in to save

The hidden threat: Unraveling the impact of microplastics on reproductive health

The Science of The Total Environment 2024 71 citations

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This review summarizes how microplastics disrupt the reproductive system in both males and females by interfering with hormone signaling, damaging the blood-testis barrier, impairing sperm production, and causing problems in the ovaries and uterus. The authors also note that microplastic exposure may affect offspring development, including their future reproductive capacity and metabolism.

Body Systems

Microplastics, with intricate physical and chemical characteristics, infiltrate the food chain and extensively impact ecosystems. Despite acknowledging the link between environmental pollution and declining fertility, the specific mechanisms affecting reproductive health remain to be elucidated. This review emphasizes the global correlation between microplastics and subfertility, focusing on entry pathways and impacts on ecosystems. Research suggests that microplastics disrupt the neuroendocrine system, influencing sex hormone synthesis through the hypothalamic-pituitary-gonadal (HPG) axis. In the reproductive system, microplastics interfere with the blood-testis barrier, impairing spermatogenesis in males, and causing placental dysfunction, ovarian atrophy, endometrial hyperplasia, and fibrosis in females. Moreover, microplastics potentially affect offspring's lipid metabolism and reproductive functions. However, complex microplastic compositions and detection method limitations impede research progress. Mitigation strategies for reproductive effects, combined with addressing microplastic pollution through sustainable practices, are imperative. This review underscores the urgency of global initiatives and collaborative research to safeguard reproductive health amid escalating microplastic contamination.

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This review summarizes how microplastics and nanoplastics can harm both male and female reproductive systems by disrupting hormone signaling, damaging sperm and egg cells, and causing inflammation in reproductive tissues. Smaller nanoplastics are especially concerning because they can cross biological barriers more easily and reach the testes and ovaries. With global infertility rates rising, the authors highlight environmental plastic exposure as a factor that deserves more research attention.

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