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Exploring the impact of polyethylene terephthalate nanoplastics on male reproductive health: Insights from a mouse model study
Summary
Researchers investigated the effects of PET nanoplastics on male reproductive function, examining sperm quality, hormone levels, and testicular tissue in animal models. PET nanoplastic exposure reduced sperm motility and caused histological changes in testicular tissue, suggesting a potential role in male infertility.
Infertility, defined as the inability to achieve pregnancy after 12 months or more of regular unprotected sexual intercourse, is influenced by various genetic and environmental factors. Among these factors, exposure to microplastics and nanoplastics (NPs) has emerged as a potential contributor to male infertility. In this study, we aimed to investigate the effects of sub-chronic exposure to polyethylene terephthalate (PET) nanoplastics on male reproductive health using a mouse model. For this aim first, we produced 56 nm PET-NPs by dilution-precipitation technique. Then, eighteen Balb-C mice, randomly divided into three groups (n=6) were exposed to 0, 0.1, and 0.5 mg/day PET-NPs for 28 days by oral gavage. Following the sub-chronic exposure testis index, sperm counts and morphology, DNA strand breaks, and spermatogenesis were evaluated. Our data revealed that sub-chronic exposure to PET-NPs did not significantly affect testis index in both PET-NP exposed groups compared to the control. On the other hand, both 0.1 and 0.5 mg/day PET-NP exposed groups exhibited a significant decrease in sperm counts (P Also see: https://micro2024.sciencesconf.org/558671/document
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