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61,005 resultsShowing papers similar to Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Bushen Huashi decoction against kidney stones
ClearThe potential mechanism of huazhuojiedu decoction in the treatment of ulcerative colitis based on network pharmacology and experimental validation
Researchers used network pharmacology to identify 119 active components and 146 potential targets of the traditional Chinese medicine formula Huazhuojiedu decoction relevant to ulcerative colitis, then validated key predicted mechanisms in dextran sulfate sodium-induced rat colitis models, elucidating multi-target pathways underlying the formula's clinically observed therapeutic effects.
The Traditional Chinese Medicine in Treating Diabetic Nephropathy: A Bibliometric Analysis
This bibliometric analysis reviews research trends on Traditional Chinese Medicine for treating diabetic nephropathy. The study identifies key research hotspots including the clinical efficacy of herbal treatments and their pharmacological mechanisms, with improving oxidative stress and regulating gut microbiota highlighted as promising directions for future investigation.
Mechanisms underlying the therapeutic effects of Semen cuscutae in treating recurrent spontaneous abortion based on network pharmacology and molecular docking
Researchers used network pharmacology and molecular docking to investigate how compounds from the traditional Chinese medicine Semen cuscutae may interact with inflammatory targets related to recurrent spontaneous abortion. The study identified sesamin as a key compound that showed strong binding affinity to relevant molecular targets, providing a theoretical basis for further investigation of this traditional remedy.
Trends in Research on The Effects of Nutritional Supplements Against Nephrotoxicity; A Bibliometric Study
A bibliometric analysis of the 100 most-cited articles on nutritional supplements against nephrotoxicity (2001–2023) found growing research interest in antioxidants, probiotics, and phytochemicals as protective agents against drug-induced kidney damage. The analysis mapped research trends and identified gaps in clinical translation of these findings.
Pharmacodynamic Material Basis and Potential Mechanism Study of Spatholobi Caulis in Reversing Osteoporosis
Researchers investigated the pharmacological mechanisms of Spatholobi Caulis (SC) in reversing osteoporosis, finding it operates through multi-component, multi-target pathways with the AGE-RAGE signaling pathway identified as the primary regulatory mechanism.
Ameliorative Effects of Rhamnetin against Polystyrene Microplastics-Induced Nephrotoxicity in Rats
Researchers investigated whether the flavonoid rhamnetin could protect against kidney damage caused by polystyrene microplastics in rats. The study found that microplastic exposure significantly increased oxidative stress and inflammatory markers while reducing antioxidant enzyme activity, but co-treatment with rhamnetin restored kidney parameters and mitigated the damage.
Attenuative Effects of Ginkgetin Against Polystyrene Microplastics-Induced Renal Toxicity in Rats
Researchers found that ginkgetin, a natural flavonoid, significantly reduced polystyrene microplastic-induced kidney damage in rats by restoring antioxidant enzyme activity and reducing oxidative stress and inflammation markers.
Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion
Researchers investigated the therapeutic mechanism of salidroside for intestinal ischemia-reperfusion injury using network pharmacology and experimental validation, finding that it may target AMPK and TXNIP domains to provide protective effects.
Potential application of traditional Chinese medicine in cerebral ischemia—Focusing on ferroptosis
This review examined evidence for traditional Chinese medicine compounds in treating cerebral ischemia by targeting ferroptosis, an iron-dependent form of regulated cell death. Multiple TCM-derived compounds including flavonoids and alkaloids showed neuroprotective effects through ferroptosis pathway inhibition in experimental ischemia models.
Protective Effect of Paeoniae Radix Alba Carbonisata on Hepatic Amyloidosis by Regulating Calcium Homeostasis
Scientists tested a traditional Chinese herbal medicine called PRAC on a serious liver condition where harmful proteins build up and damage the organ. The herb extract helped protect liver cells and reduced inflammation by fixing problems with calcium balance inside cells. While this is early research done in lab dishes and mice, it suggests this traditional remedy might help treat certain types of liver disease, though human studies are still needed.
Narirutin ameliorates polystyrene microplastics induced nephrotoxicity by modulating oxidative stress, inflammation and Nrf2/Keap1 pathway
Researchers investigated whether narirutin, a natural compound found in citrus fruits, could protect kidneys from damage caused by polystyrene microplastics in rats. The study suggests that microplastic exposure triggered significant kidney stress through oxidation and inflammation, but narirutin helped reduce that damage by activating protective cellular pathways.
Mechanism of P-Hydroxy Benzyl Alcohol Against Cerebral Ischemia Based on Metabonomics Analysis
Researchers investigated how p-hydroxybenzyl alcohol, an active compound from the traditional medicinal plant Gastrodia elata, protects against brain damage caused by reduced blood flow. Using metabolomics in cell and rat models, they identified that the compound works by improving mitochondrial function and reducing excessive autophagy through a specific signaling pathway. The study provides new molecular targets that could inform future treatments for cerebral ischemia.
Sciadopitysin attenuates paraquat induced renal toxicity by modulating Nrf2/Keap-1 pathway in male albino rats
Researchers investigated whether the plant compound sciadopitysin could protect against kidney damage caused by the herbicide paraquat in rats. They found that sciadopitysin significantly reduced oxidative stress and inflammation in the kidneys by activating the Nrf2/Keap-1 protective pathway. The study suggests that natural biflavonoid compounds may help mitigate organ damage from toxic environmental chemical exposures.
Wcn23-0028 Dietary Sodium and Potassium Intakes and Prevalent Kidney Stone: the National Health and Nutritional Examination Survey 2011-2018
Researchers examined associations between dietary sodium and potassium intakes and the prevalence of kidney stones using national survey data from 2011–2018, finding that dietary mineral ratios may influence kidney stone risk. The study contributes to understanding how diet composition relates to urinary tract health.
Genotoxicity Assessment of Hwanglyeonhaedok-Tang: An Herbal Formula Evaluated Using the In Vivo Alkaline Comet Assay and Pig-a Gene Mutation Assay in Rats
Researchers tested whether the traditional Asian herbal formula Hwanglyeonhaedok-tang caused DNA damage in rats using in vivo comet and Pig-a gene mutation assays, following earlier positive in vitro genotoxicity results. The in vivo assays did not confirm genotoxicity, suggesting the previous signals may be false positives under realistic dosing conditions.
Sakuranetin counteracts polyethylene microplastics induced nephrotoxic effects via modulation of Nrf2/Keap1 pathway
Researchers found that polyethylene microplastics caused kidney damage in rats by increasing oxidative stress and disrupting a key protective cellular pathway. However, when the natural plant compound sakuranetin was administered alongside the microplastics, it significantly reduced the kidney damage by restoring antioxidant defenses. The study suggests that certain natural compounds may help counteract some of the harmful effects of microplastic exposure on organ health.
Tea Polyphenols Mitigate TBBPA-Induced Renal Injury Through Modulation of ROS-PI3K/AKT-NF-κB Signalling in Carp (Cyprinus carpio)
Researchers found that tea polyphenols, the beneficial compounds in tea, helped protect carp kidneys from damage caused by the flame retardant chemical TBBPA. The tea compounds reduced oxidative stress, inflammation, and cell death in kidney tissue by modulating key signaling pathways. The study suggests that natural antioxidants like those found in tea may help mitigate some of the harmful effects of environmental chemical pollutants on aquatic organisms.
Protective Effect of Astragaloside IV against Cadmium-Induced Damage on Mouse Renal Podocytes (MPC5)
This paper is not about microplastics; it investigates how the plant compound Astragaloside IV protects kidney cells from cadmium-induced damage, examining mitochondrial and autophagy pathways.
Repair mechanism of Yishen Tongluo formula on mouse sperm DNA fragmentation caused by polystyrene microplastics
This study investigated a traditional Chinese medicine formula (Yishen Tongluo) for its potential to repair sperm DNA damage caused by polystyrene microplastics. Researchers found that the formula's protective mechanism may be associated with the PI3K/Akt signaling pathway and the protein SPARC. The study suggests a new direction for using traditional medicine approaches to address reproductive system injury linked to microplastic exposure.
Evaluation of Possible Ameliorative Role of Robinetin to Counteract Polystyrene Microplastics Instigated Renal Toxicity in Rats
Researchers tested whether robinetin, a plant-derived compound, could protect rat kidneys from damage caused by polystyrene microplastic exposure. They found that microplastics caused significant kidney harm through oxidative stress, inflammation, and cell death, but robinetin supplementation substantially reversed these effects. The study suggests that natural antioxidant compounds may offer a protective strategy against microplastic-related organ damage.
Evaluation of Biochemical Properties, Antioxidant Activities and Phenolic Content of Two Wild-Grown Berberis Fruits: Berberis nummularia and Berberis atrocarpa
Researchers analyzed the biochemical composition, phenolic content, and antioxidant capacity of wild-growing Berberis nummularia and Berberis atrocarpa fruits from Xinjiang, China. Both species showed significant antioxidant activity attributed to their high phenolic and flavonoid content, suggesting potential as functional food ingredients.
Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS/NF-κB Axis
Researchers investigated whether dendrobine, a natural compound from orchids, could reduce cellular aging and osteoarthritis symptoms in lab and animal models. They found that dendrobine decreased oxidative stress and inflammation by suppressing the ROS/NF-kB signaling pathway, which reduced cartilage breakdown and cellular senescence. The study suggests dendrobine may have potential as a therapeutic approach for age-related joint degeneration.
Micro/nanoplastic-driven cardiovascular senescence and multi-target intervention by traditional Chinese medicine
Researchers reviewed how micro- and nanoplastics accumulate in cardiovascular tissues and accelerate cellular aging through mitochondrial damage, epigenetic changes, telomere shortening, and chronic inflammation, while also highlighting traditional Chinese medicine's multi-target compounds as a potential countermeasure by simultaneously addressing oxidative stress, fibrosis, and cell death pathways.
Renoprotective Effect of Chrysanthemum coronarium L. Extract on Adenine-Induced Chronic Kidney Disease in Mice
Researchers investigated the renoprotective effects of Chrysanthemum coronarium extract on adenine-induced chronic kidney disease in mice, finding it reduced inflammation and fibrosis markers associated with progressive loss of renal function.