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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Reproductive & Development Sign in to save

Repair mechanism of Yishen Tongluo formula on mouse sperm DNA fragmentation caused by polystyrene microplastics

Pharmaceutical Biology 2023 20 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Chenming Zhang, Zulong Wang, Sicheng Ma, Rubing Chen, Shiqi Wang, Hao Zhang, Zhong Hua, Zi-Xue Sun

Summary

This study investigated a traditional Chinese medicine formula (Yishen Tongluo) for its potential to repair sperm DNA damage caused by polystyrene microplastics. Researchers found that the formula's protective mechanism may be associated with the PI3K/Akt signaling pathway and the protein SPARC. The study suggests a new direction for using traditional medicine approaches to address reproductive system injury linked to microplastic exposure.

Polymers
PS
Body Systems
Reproductive
Models
Mouse

The precise mechanism by which YSTL inhibits PD-MPs DNA damage may be associated with the PI3K/Akt pathway and SPARC. It provides a new direction for using traditional Chinese medicine to prevent and repair reproductive system injury caused by MPs.

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