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61,005 resultsShowing papers similar to Toxicity Test of Strong Drug Using the BSLT (Brine Shrimp Lethality Test) Method
ClearEvaluation of the Effects of Three Chemical Fertilizers on Artemia salina
Researchers tested the toxicity of three common agricultural fertilizers on brine shrimp (Artemia salina) as part of ecotoxicological screening. All three fertilizers caused lethal effects that increased with concentration. Brine shrimp toxicity testing provides a standardized way to assess the environmental risks of agricultural chemicals before they are widely applied.
Pharmaceutical Products and Pesticides Toxicity Associated with Microplastics (Polyvinyl Chloride) in Artemia salina
Researchers investigated the combined toxicity of polyvinyl chloride microplastics with pharmaceutical products and pesticides on brine shrimp, finding that microplastic mixtures altered the toxic effects of these chemical contaminants on aquatic organisms.
Highly Diluted Glyphosate Mitigates Its Effects on Artemia salina: Physicochemical Implications
Researchers found that highly diluted glyphosate mitigated its own toxic effects on Artemia salina (brine shrimp), with physicochemical analysis suggesting that serial dilutions alter the herbicide's molecular organization and biological activity.
Towards standard methods for the classification of aquatic toxicity for biologically active household chemicals (BAHC) present in plastics, pharmaceuticals, and cosmetic products
Researchers proposed a standardized testing method using marine invertebrate models to assess the aquatic toxicity of biologically active household chemicals found in plastics, pharmaceuticals, and cosmetics, including substances with very low water solubility.
Ecotoxicity Study Using Dibenzothiophene and Mercury Chloride in "Brine Shrimp"
Researchers determined LC50 values for dibenzothiophene and mercuric chloride individually in Artemia franciscana (brine shrimp) and then tested their combined toxicity. DBT was approximately 10 times more toxic than HgCl2 (LC50 of 3.89 vs. 33.11 mg/L), and in combination the compounds showed pronounced lethal synergy causing 100% mortality at all tested concentrations.
Impact of Benzodiazepine Delorazepam on Growth and Behaviour of Artemia salina Nauplii
Researchers examined the effects of the benzodiazepine delorazepam on the development of brine shrimp (Artemia salina) larvae at environmentally relevant concentrations. They found that exposure increased hatching rates but disrupted normal growth synchronization, altered lipid reserve consumption, and reduced locomotor activity at the highest dose. The study adds to growing evidence that pharmaceutical contaminants in water can affect the development and behavior of aquatic invertebrates.
Comparative acute toxicity study of Syringodium isoetifolium on aquatic and rodent experimental animals
This paper is not about microplastics; it tests the acute toxicity of a seagrass (Syringodium isoetifolium) extract on brine shrimp, zebrafish, and rats to evaluate its safety profile for potential pharmaceutical use.
Assessing the Biodistribution and Toxicity of Fluorescently Dyed Nano-Polystyrene in Artemia salina Nauplii
Researchers tracked the distribution and toxic effects of polystyrene nanoplastics in brine shrimp, a key model organism for ecotoxicology. They found that nanoplastics accumulated in the gut and, at higher concentrations, caused gut deformities, with the lethal concentration decreasing by nearly half between 24 and 48 hours of exposure. The findings suggest that nanoplastics may also impair the salt gland, affecting osmoregulation and energy allocation in marine organisms.
Acute toxicity assessment of nine organic UV filters using a set of biotests
Researchers tested the acute toxicity of nine UV-filtering chemicals found in sunscreens and personal care products on four aquatic species — including brine shrimp, water fleas, marine bacteria, and freshwater plants — finding all nine were acutely toxic, with octocrylene posing the greatest risk to animal life. When tested as mixtures, some combinations showed reduced combined toxicity, but a binary mix of benzophenone-2 with octocrylene or homosalate was highly toxic to marine bacteria.
Comparative Toxicological Evaluation of Solubilizers and Hydrotropic Agents Using Daphnia magna as a Model Organism
Researchers tested the safety of 15 common chemicals used to dissolve pharmaceuticals for lab testing, using the water flea Daphnia magna as a model organism. They found that some surfactants were extremely toxic even at very low concentrations, while solvents like DMSO and glycerol were much safer at standard doses. The findings help guide safer choices for lab testing of water-insoluble compounds, which is relevant to accurate environmental toxicity assessments of pollutants including microplastics.
Pharmaceuticals and personal care products and their sublethal and lethal effects in aquatic organisms
A literature review of pharmaceuticals and personal care products (PPCPs) in aquatic environments identified the range of concentrations producing sublethal and lethal effects in diverse aquatic organisms, noting persistence and bioaccumulation as key concerns and gaps in understanding long-term exposure impacts.
Investigating on the toxicity and bio-magnification potential of synthetic glitters on Artemia salina
Researchers assessed the toxic effects of polyethylene terephthalate glitter microplastics on Artemia salina (brine shrimp) as a model zooplankton species. The study found that glitter ingestion caused gut wall damage, decreased cholinesterase activity, and demonstrated biomagnification potential, suggesting that synthetic glitter particles pose measurable toxicological risks to aquatic organisms.
Comparación ecotoxicológica al Cloruro de Sodio en Hydra vulgaris e Hydra viridissima
This study compared the ecotoxicological effects of sodium chloride on two freshwater Hydra species, establishing baseline tolerance levels for these aquatic invertebrates. The work contributes to understanding how salt contamination in freshwater ecosystems affects sensitive organisms.
A combined toxicological impact on Artemia salina caused by the presence of dust particles, microplastics from cosmetics, and paracetamol
Researchers exposed brine shrimp to a combination of dust particles, cosmetic microplastics, and paracetamol to study their combined toxicity. The findings indicate that multiple pollutants together caused greater harm than any single pollutant alone, reducing hatching rates, survival, and antioxidant defenses, which highlights how real-world mixtures of contaminants can amplify damage to aquatic life.
The genus Artemia, the nanoplastics, the microplastics, and their toxic effects: a review
This review critically examined studies that used brine shrimp (Artemia) as test organisms to investigate the harmful effects of micro- and nanoplastic particles on marine life. Researchers identified key gaps in current research, including insufficient characterization of the plastic particles used and inconsistent experimental methods across studies. The study suggests that standardizing experimental approaches and better describing plastic test materials would significantly improve our understanding of how small plastic particles affect marine organisms.
(Bio)monitoring of pharmaceuticals in the Mediterranean aquatic environment and interactive effect with microplastics. Insights from field and laboratory studies
This biomonitoring study surveyed the presence of pharmaceutical compounds in Mediterranean aquatic environments, measuring concentrations in water, sediment, and biota across multiple sampling sites. Several drugs were detected at levels of potential concern for aquatic organisms.
Investigation of Possible Toxic Effects of Personal Care Products on Daphnia magna in the Kucukcekmece Lagoon, Marmara Sea (Turkey)
This study measured the acute toxicity of polyethylene glycols and personal care products like baby shampoo and body lotion to the freshwater crustacean Daphnia magna. The findings suggest that at high enough concentrations, common personal care product ingredients can be toxic to small aquatic organisms.
Toxicological effects of microplastics and sulfadiazine on Artemia sinica
Researchers exposed the brine shrimp Artemia sinica to the antibiotic sulfadiazine and polystyrene microplastics individually and in combination, finding that all treatments reduced swimming speed and altered antioxidant capacity, with combined exposure producing exacerbated effects.
Exposure of Zebrafish (Danio rerio) to Clioquinol Reveals Embryological and Developmental Toxicity
Researchers found that clioquinol, an antimicrobial compound being reconsidered for new clinical uses, causes dose-dependent embryological toxicity in zebrafish, including 100% mortality at higher concentrations within 48 hours, raising concerns about its safety for potential reintroduction.
A Review on the Main Antibiotic Drugs Used in Fish Farming: Ecotoxicity, Characterization and Remediation
This review examines antibiotics used in fish farming and their ecotoxicological effects on aquatic ecosystems, noting that pharmaceutical residues accumulate in water and sediments and promote antibiotic-resistant bacteria. Understanding drug fate and effects in aquaculture environments is important for protecting both ecosystem health and the safety of farmed seafood.
On measuring nanoparticle toxicity and clearance with Paramecium caudatum
Researchers used the single-celled organism Paramecium caudatum to test how nanoparticles affect aquatic life and how quickly they are cleared from cells. The study provides a simple model system for evaluating nanoparticle (and potentially nanoplastic) toxicity in aquatic environments.
Bioaccumulation/bioconcentration of pharmaceutical active compounds in aquatic organisms: Assessment and factors database
This review compiles data on how pharmaceutical compounds accumulate in aquatic organisms including fish, mussels, and crustaceans. Researchers created a comprehensive database of bioaccumulation factors and identified key variables that influence how much of a drug builds up in different species and tissues. The findings help improve risk assessments for pharmaceutical pollution in waterways and its potential impact on ecosystems.
Toxicity effects of Ciprofloxacin on biochemical parameters, histological characteristics, and behaviors of Corbicula fluminea in different substrates
Researchers found that the antibiotic ciprofloxacin in river sediments caused liver damage, immune suppression, and behavioral changes in freshwater clams. This shows that sediment-associated pharmaceutical pollutants—which often co-occur with microplastics in riverbed sediments—can harm important filter-feeding organisms.
Comparative toxicity of polystyrene, polypropylene, and polyethylene nanoplastics on Artemia franciscana nauplii: a multidimensional assessment
Researchers compared the toxic effects of three common plastic types — polystyrene, polypropylene, and polyethylene — in nanoplastic form on brine shrimp larvae. They found that all three types caused harm, but polystyrene nanoplastics were the most toxic across multiple biological measures. The study provides the first direct comparison showing that the chemical composition of nanoplastics significantly influences their toxicity to aquatic organisms.