We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Quantifying Nanoplastic Toxicity Using Gold-Core Polystyrene Nanoparticles: In vivo Evaluation and Human Risk Extrapolation
ClearQuantifying Nanoplastic Toxicity Using Gold-Core Polystyrene Nanoparticles: In vivo Evaluation and Human Risk Extrapolation
Researchers used gold-core polystyrene nanoparticles as a dual-detectable model to quantify nanoplastic toxicity in vivo, finding that chronic exposure induced intestinal accumulation and systemic toxicity, and used these data to extrapolate human health risk thresholds.
Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro
Researchers assessed the toxicity and transport of polystyrene nano- and microparticles using multiple human cell models, including intestinal and placental barrier systems. They found that while neither size was acutely toxic, the nanoparticles were able to cross the intestinal barrier and showed some embryotoxic potential. The study suggests that nanoplastics may pose greater health concerns than microplastics due to their ability to penetrate biological barriers.
Fate, uptake and impact of fit-for-purpose nanoplastics on the digestive environment: an in vitro-in vivo continuum study
Researchers used fluorescently and gold-labeled polystyrene nanoplastics as models to study how these particles behave in the digestive environment and what effects they have on gut health. The study revealed that nanoplastics interact with the digestive system in ways that depend on particle labeling and surface properties.
Toxicity-based toxicokinetic/toxicodynamic assessment for bioaccumulation of polystyrene microplastics in mice
Researchers developed a toxicity-based modeling framework to quantify how polystyrene microplastics accumulate in mouse organs and trigger biomarker responses. They found that the gut had the highest bioaccumulation factor when exposed to 5-micrometer particles, with a mean residence time of about 17 days. The study establishes threshold concentrations for toxic effects and provides a framework that could help extrapolate findings from animal studies to assess potential human health risks from microplastic consumption.
Fate, uptake and impact of fit-for-purpose nanoplastics on the digestive environment: an in vitro-in vivo continuum study
Researchers investigated the fate, uptake, and impact of fluorescent and gold-labeled polystyrene nanoplastics on the digestive environment, using fit-for-purpose labeled particles to track nanoplastic behavior in biological systems. The labeled nanoplastics enabled detailed mapping of how plastic nanoparticles are processed in the gut, providing mechanistic insight into absorption pathways.
An innovative in vitro model of IBD to assess micro-/nano-plastics intestinal toxicity.
Researchers developed an innovative in vitro intestinal inflammation model (IBD model) to assess the toxicity of micro- and nanoplastics at realistic concentrations and polymer types, moving beyond the high-dose polystyrene-only studies that dominate current literature.
Potential adverse health effects of ingested micro- and nanoplastics on humans. Lessons learned from in vivo and in vitro mammalian models
This review compiles recent studies on the effects of ingested micro- and nanoplastics using mammalian in vivo and in vitro models to assess potential human health implications. The authors found that while substantial research effort has been made, significant gaps remain in understanding absorption, biodistribution, and toxicity of these particles in mammalian systems. The review provides recommendations for improved testing methods to generate more relevant and targeted data for human risk assessment.
Interactions of polystyrene nanoplastics with in vitro models of the human intestinal barrier
Researchers assessed the effects of polystyrene nanoparticles on two in vitro models simulating the human intestinal barrier and its associated immune system. The study found that while cell viability and membrane integrity were largely maintained, the nanoparticles were able to interact with and translocate across the intestinal cell layers, raising questions about potential long-term exposure effects.
Demonstrating the translocation of nanoplastics across the fish intestine using palladium-doped polystyrene in a salmon gut-sac
Researchers used palladium-doped polystyrene nanoplastics to quantitatively measure nanoplastic uptake across the fish intestine in a salmon gut-sac model. The study found that between 200 and 700 million nanoplastics entered the intestinal tissue within four hours, with a fraction passing completely through the gut wall, providing evidence that nanoplastics can potentially distribute throughout the body.
Systemic effects of nanoplastics on multi-organ at the environmentally relevant dose: The insights in physiological, histological, and oxidative damages
Researchers gave mice nanoplastics at doses estimated to match real-world human exposure levels and found the particles crossed the intestinal barrier and accumulated in the liver and kidneys. Even at these low, environmentally relevant doses, the nanoplastics caused oxidative stress and tissue damage across multiple organs. The findings suggest that everyday nanoplastic exposure may pose broader health risks than previously assumed.
A critical review of nanoplastic bioaccumulation data and a unified toxicokinetic model: from teleosts to human brain
Researchers developed a toxicokinetic model using teleost fish uptake and depuration data to project how nanoplastics accumulate in human organs over a lifetime of chronic exposure. The model predicted that brain concentrations could reach ecologically concerning levels given current exposure estimates, and identified the gut-to-blood transfer rate as the key parameter governing long-term tissue accumulation.
Nanoplastics as a potential environmental health factor: effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells
Researchers tested how polystyrene nanoparticles interact with human intestinal cells in the lab. They found that the nanoparticles were readily taken up by the cells in a concentration-dependent manner, but no significant toxic effects were observed under the conditions tested. The study suggests that while nanoplastics can enter gut cells, their short-term toxicity at the tested levels appears limited.
Ingested nano- and microsized polystyrene particles surpass the intestinal barrier and accumulate in the body
Researchers fed mice nano- and microsized polystyrene particles for up to 24 weeks to study intestinal barrier crossing and accumulation. The study found that plastic particles accumulated in the small intestine and distant organs, though they did not promote intestinal inflammation or worsen colitis, while noting that long-term accumulative effects on gastrointestinal health cannot be ruled out.
In vivo , in vitro , and in silico toxicology studies of nanoplastics and their modeling
This in vivo, in vitro, and in silico study assessed nanoplastic toxicity through multiple complementary methods, finding concentration-dependent toxic effects on cellular and organismal endpoints and using computational modeling to predict interaction mechanisms relevant to nanoplastic risk assessment.
The Uptake and Distribution Evidence of Nano- and Microplastics in vivo after a Single High Dose of Oral Exposure.
This in vivo study provided evidence on the uptake and organ distribution of nano- and microplastics following a single high-dose administration, finding that nanoplastics translocated rapidly to multiple organs through blood circulation while only small amounts of larger microplastics penetrated organs.
Toxicity of gold nanoparticles complicated by the co-existence multiscale plastics.
This study examined how co-exposure to gold nanoparticles and plastic particles of different sizes modifies the toxicity of gold nanoparticles, finding complex interactions that altered toxic outcomes compared to gold nanoparticles alone. The results highlight that real-world toxicological risk assessment must account for co-contaminant interactions rather than testing pollutants in isolation.
In vivo impact assessment of orally administered polystyrene nanoplastics: biodistribution, toxicity, and inflammatory response in mice
Researchers orally administered polystyrene nanoplastics to mice for two weeks and tracked their distribution and biological effects. The nanoplastics accumulated primarily in the intestine, kidneys, and liver, triggering significant inflammatory responses and oxidative stress in these organs despite no visible tissue damage. The study provides evidence that even short-term oral exposure to nanoplastics can cause meaningful inflammatory changes in multiple organ systems.
Impact of UV Aging on the Toxicity and Bioavailability of Inductively Coupled Plasma Mass Spectrometry (ICP-MS)-Traceable Core–Shell Polystyrene Nanoplastics in an In Vitro Triculture Small Intestinal Epithelium Model
Researchers developed gold-core polystyrene nanoplastics traceable by mass spectrometry to study how UV aging affects nanoplastic toxicity and uptake in a human intestinal cell model. The study found that UV aging altered the surface properties and biological behavior of nanoplastics, highlighting the importance of studying environmentally realistic, weathered particles rather than only pristine laboratory materials.
Defining the size ranges of polystyrene nanoplastics according to their ability to cross biological barriers
Researchers systematically examined polystyrene nanoplastics of different sizes to define the size ranges at which they can cross biological barriers, providing a more precise definition of nanoplastic dimensions relevant to toxicological assessment.
Penetration of micro/nanoplastics into biological barriers in organisms and associated health effects
This Chinese-language review systematically examined how micro- and nanoplastics penetrate gastrointestinal, respiratory, and skin barriers in humans and model organisms, and how they translocate via blood circulation to accumulate in organs including the liver, brain, testes, and placenta.
Polystyrene Nanoplastics as Carriers of Metals. Interactions of Polystyrene Nanoparticles with Silver Nanoparticles and Silver Nitrate, and Their Effects on Human Intestinal Caco-2 Cells
Researchers investigated whether polystyrene nanoplastics can act as carriers of silver contaminants, testing their interactions with silver nanoparticles and silver nitrate and their combined effects on human intestinal Caco-2 cells. The study found that nanoplastics can adsorb silver compounds and that the combined exposure increased toxicity compared to either contaminant alone, suggesting nanoplastics may enhance metal uptake in the human gut.
Nanoplastic Toxicity: Insights and Challenges from Experimental Model Systems
This review summarizes what researchers have learned about nanoplastic toxicity from studies in cell cultures, aquatic organisms, and terrestrial animals. Evidence indicates that nanoplastics can be internalized by cells through various mechanisms and their toxicity depends on factors like particle size, surface modifications, and concentration. The study identifies key knowledge gaps and recommends more systematic research to better understand the health risks these particles may pose to humans.
Imaging and quantifying the biological uptake and distribution of nanoplastics using a dual-functional model material
This study used advanced imaging techniques to visualize and quantify nanoplastic uptake and distribution in biological systems, tracking particle translocation from exposure routes into tissues and characterizing intracellular localization.
Blood uptake and urine excretion of nano- and micro-plastics after a single exposure.
Mice exposed to polystyrene nanoparticles (100 nm) and microparticles (3 µm) via different routes showed that smaller particles appeared rapidly in blood and were detected in urine, while larger particles cleared more slowly. The study provides direct evidence that nanoplastics can cross biological barriers and enter circulation, with potential for distribution throughout the body.