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Papers
61,005 resultsShowing papers similar to Biomembrane-wrapped gene delivery nanoparticles for cancer therapy
ClearArtificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy
Researchers reviewed how engineering the protein corona — the layer of proteins that coats nanoparticles in biological fluids — through modifications like PEGylation and protein pre-coating can improve nanoparticle targeting for cancer drug delivery by controlling how immune cells recognize and clear the particles.
Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment
This review covers advances in targeted drug delivery using nanotechnology, including nanoparticles and liposomes designed to release medications precisely where needed in the body. While focused on cancer treatment, the drug delivery technologies discussed are relevant to understanding how nanoscale plastic particles may also travel through the body and accumulate in specific tissues.
Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
This review examines how nanotechnology-based approaches can regulate lipid metabolism in tumor microenvironments to enhance anti-cancer immune responses, covering lipid nanoparticles, liposomes, and other delivery systems. The authors identify lipid metabolic reprogramming as a promising immunotherapy target and nanotechnology as a key enabler for delivering therapeutics that reshape tumor-associated metabolic pathways.
IL-11-Engineered Macrophage Membrane-Coated Reactive Oxygen Species-Responsive Nanoparticles for Targeted Delivery of Doxorubicin to Osteosarcoma
Researchers designed reactive oxygen species-responsive nanoparticles coated with interleukin-11-engineered macrophage membranes for targeted doxorubicin delivery to osteosarcoma tumors in children and adolescents. The biomimetic nanocarriers evaded immune clearance and selectively accumulated at tumor sites, improving chemotherapy delivery efficiency in preclinical models.
Hydrogel-based nanoparticles: revolutionizing brain tumor treatment and paving the way for future innovations
Researchers reviewed how nanoparticles embedded in hydrogels — water-based gel materials — can serve as targeted drug delivery vehicles for brain tumors by crossing the blood-brain barrier, a major obstacle that blocks most medications from reaching the brain. These systems have shown improved survival rates in studies, and the review outlines remaining challenges around manufacturing, stability, and scaling up for clinical use.
Nanoparticles in Drug Delivery
This review examines how nanoparticles made from various materials, including polymers, are being developed for targeted drug delivery across biological barriers. Researchers highlighted advances in stimuli-responsive nanoparticle engineering for tumor targeting and the integration of AI models for personalized medicine. While focused on biomedical applications, the study is relevant to understanding how polymer-based particles interact with biological systems at the nanoscale.
Nanomaterials in Drug Delivery: Strengths and Opportunities in Medicine
This review covers how nanomaterials are being used to improve drug delivery for treating cancer and infections, offering better targeted therapy with fewer side effects. While not directly about microplastics, the research on how nanoparticles interact with human tissues provides insight into how similarly sized nanoplastics might behave once inside the body.
Nanoparticle-Based Delivery Systems for Vaccines
This review examines how nanoparticle-based delivery systems are improving vaccine effectiveness by enabling precise control over particle size, shape, and surface properties. Researchers found that these nanovaccines address many shortcomings of traditional vaccines, including low immunogenicity and incomplete protection. The study provides an overview of how advances in chemical and biological engineering are enabling more robust immune responses through improved antigen presentation.
The quest for nanoparticle-powered vaccines in cancer immunotherapy
This review explores how nanoparticles are being developed as cancer vaccine delivery systems to train the immune system to fight tumors more effectively. While focused on cancer immunotherapy rather than microplastics, the research highlights that understanding how nanoparticles interact with the immune system is crucial -- the same principles apply to understanding how nanoplastics may affect immune responses in the body.
Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
This review explores how nanotechnology is being used to overcome drug resistance in cancer treatment, using materials like carbon nanotubes, dendrimers, and liposomes to deliver drugs more precisely to tumors. While not directly about microplastics, the nanomaterial strategies discussed share relevance with understanding how nano-sized plastic particles interact with human cells and tissues.
Nanoparticle-cell Membrane Interactions: Adsorption Kinetics and the Monolayer Response
This thesis investigated how engineered nanoparticles interact with cell membranes, including adsorption kinetics and how membranes respond to particle contact. Understanding nanoparticle-membrane interactions is directly relevant to how nanoplastics may enter cells and cause biological harm.
Polymer-based nanocarriers for biomedical and environmental applications
This review covers the fabrication, design, and applications of polymer-based nanocarriers in biomedical and environmental fields. The study highlights their use in targeted drug delivery and cancer therapy, as well as their ability to remove heavy metals and contaminants from air and water, while noting current challenges for future development.
Cellular journey of nanomaterials: Theories, trafficking, and kinetics
This review traces the cellular journey of engineered nanomaterials after they enter the human body, covering how particles cross cell membranes, travel through cellular compartments, and are either stored or expelled. Researchers found that a nanomaterial's size, shape, and surface chemistry all influence how cells process it. The study highlights the importance of understanding these cellular pathways for evaluating both the therapeutic potential and safety risks of nanomaterials.
Application of Hydrogel as Drug Carrier in Tumor Therapy
This review summarizes recent advances in hydrogel-based drug delivery systems for cancer therapy, focusing on their ability to achieve controlled drug release and respond to tumor microenvironment signals for targeted treatment.
The ancillary effects of nanoparticles and their implications for nanomedicine
Researchers reviewed 'ancillary effects' — the unintended biological interactions between nanoparticles and living systems that occur independent of engineered targeting or therapeutic functions — cataloguing how nanomaterial surface properties can modulate cell signaling, immune responses, and toxicity in ways that have major implications for nanomedicine safety and design.
Peptide-Based Nanoparticles for Systemic Extrahepatic Delivery of Therapeutic Nucleotides
This review explores how peptide-based nanoparticles can be used to deliver therapeutic genetic material to organs beyond the liver after being injected into the bloodstream. Researchers summarize the mechanisms behind how these nanoparticles self-assemble, enter cells, and escape cellular compartments to reach their targets. The findings point to promising possibilities for using these delivery systems in treating diseases that current approaches struggle to reach.
Nanoplastic–Biomolecular Interactions
This review examines how nanoplastics interact with the biomolecules of living organisms — including proteins, DNA, lipids, and cellular membranes — and how these interactions drive biological harm at the molecular level. Understanding nanoplastic-biomolecule interactions is foundational to explaining why plastic particles at the nanoscale may pose greater health risks than larger microplastics, since they can penetrate cell membranes and reach intracellular targets.
An updated overview of some factors that influence the biological effects of nanoparticles
This review provides an updated look at how the size, shape, chemical composition, and surface properties of nanoparticles influence their biological effects when they enter the body. Researchers summarize how these physical characteristics determine how nanoparticles interact with proteins, cell receptors, and other biological molecules. The study highlights the importance of understanding these factors for both the safe design of medical nanoparticles and for assessing environmental nanoparticle risks.
Form and Function: The Factors That Influence the Efficacy of Nanomaterials for Gene Transfer to Plants
This review discusses using nanoparticles to deliver genes into plant cells for crop improvement, covering factors like particle size, cell wall barriers, and potential toxicity concerns. While focused on agricultural biotechnology rather than microplastics directly, it highlights how nanoscale particles interact with plant biology. Understanding how tiny particles enter and affect plant cells is relevant to research on how nanoplastics may similarly penetrate food crops.
Nanoplastics as a return to the prebiotic dimensional regime: A dimensional perspective on interactions with biological membranes
This conceptual paper argues that nanoplastics are environmentally significant not primarily because of chemical toxicity, but because their nanoscale dimensions place them in the same physical regime as prebiotic structures that interact directly with biological membranes. The author proposes that membrane disruption, rather than chemical toxicity, is the key mechanism of nanoplastic harm.
Dipolar Nanoparticle Interacting with a Lipid Membrane
Researchers used molecular dynamics simulation to investigate how the electric dipole moment of conductive nanoparticles affects their interaction with lipid bilayer membranes, finding that dipole moment induces stronger electrostatic attraction and alters membrane penetration dynamics relevant to drug delivery and nanomedicine.
Converging frontiers in cancer treatment: the role of nanomaterials, mesenchymal stem cells, and microbial agents—challenges and limitations
This review examines three cutting-edge approaches to cancer treatment: nanomaterials for targeted drug delivery, mesenchymal stem cells as carriers for therapeutic agents, and microbial agents that can selectively attack tumors. Each approach aims to overcome the limitations of conventional treatments like chemotherapy and radiation, which often damage healthy tissue and lead to drug resistance. The authors discuss both the promise and the remaining challenges of bringing these innovative therapies into clinical practice.
Reconstructed membrane vesicles from the microalga Dunaliella as a potential drug delivery system
Researchers reconstructed tiny bubble-like vesicles from microalgae cell membranes and tested their potential as drug delivery vehicles. The vesicles proved soft, water-friendly, and semi-permeable to certain molecules, pointing to a sustainable, ocean-inspired approach for transporting medicines or studying how materials move across biological membranes.
How to Treat Melanoma? The Current Status of Innovative Nanotechnological Strategies and the Role of Minimally Invasive Approaches like PTT and PDT
This review summarizes advances in nanotechnology-based treatments for melanoma, including photothermal and photodynamic therapies using engineered nanoparticles as drug carriers and light absorbents. While nanoparticle-based therapies show promise for improving treatment outcomes, the environmental fate of these engineered nanomaterials remains a concern, as nanoparticles can behave similarly to microplastics when released into ecosystems.