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Nanoparticle-cell Membrane Interactions: Adsorption Kinetics and the Monolayer Response
Summary
This thesis investigated how engineered nanoparticles interact with cell membranes, including adsorption kinetics and how membranes respond to particle contact. Understanding nanoparticle-membrane interactions is directly relevant to how nanoplastics may enter cells and cause biological harm.
The fast-growing production and utilization of nanomaterials in diverse applications will undoubtedly lead to the release of these materials into the environment. As nanomaterials enter the environment, determining their interaction with biological systems is a key aspect to understanding their impact on environmental health and safety. It has been shown that engineered nanoparticles (ENPs) can interact with cell membranes by adhering onto their surface and compromising their integrity, permeability, and function. The interfacial and biophysical forces that drive these processes can be examined using lipid monolayers or bilayers as model cell membranes.
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