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61,005 resultsShowing papers similar to Systematic Review: Efek Nanoplastik terhadap Metilasi DNA pada Manusia
ClearNanoplastics as Epigenetic Disruptors: A Biochemical Review of Environmental Pollutants and Gene Regulation
This biochemical review examined how nanoplastics disrupt epigenetic regulation, focusing on their ability to alter DNA methylation patterns, histone modifications, and non-coding RNA expression. The authors argued that nanoplastic-induced epigenetic changes could have lasting developmental and health consequences, especially during vulnerable life stages.
Micro(nano)plastics in the brain: Epigenetic perturbations in progression to neurodegenerative diseases.
This review examined how micro(nano)plastics (MNPs) accumulate in the brain and induce epigenetic changes—including DNA methylation and histone modification—that may drive the progression of neurodegenerative diseases. MNPs were found to disrupt neuronal homeostasis through multiple epigenetic mechanisms after crossing the blood-brain barrier.
Beyond genetics: can micro and nanoplastics induce epigenetic and gene-expression modifications?
This review gathers existing research on whether micro and nanoplastics can cause epigenetic changes, which are modifications that alter how genes work without changing the DNA itself. Although studies are still limited, the evidence so far shows that both short-term and long-term plastic particle exposure can trigger these gene-level changes in various organisms. This is concerning because epigenetic changes can potentially be passed to future generations and may contribute to disease.
Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health
This review examines how breathing in particulate matter from air pollution -- which can include microplastic particles -- causes lasting health damage through epigenetic changes, meaning it alters how genes are turned on and off without changing the DNA itself. These changes have been linked to cancer, lung scarring, brain diseases, and metabolic disorders. The findings suggest that airborne microplastics could contribute to disease through similar epigenetic mechanisms.
A systematic review of associations between the environment, DNA methylation, and cognition
This systematic review of 14 studies found that DNA methylation statistically mediates the association between environmental exposures (air pollution, heavy metals, pesticides) and cognitive outcomes in 10 of the 14 studies. While the review focuses broadly on environmental epigenetics rather than microplastics specifically, it provides a framework for understanding how pollutant exposures may drive neurodegenerative disease through epigenetic mechanisms.
A systematic review on the impact of micro-nanoplastics on human health: Potential modulation of epigenetic mechanisms and identification of biomarkers
This systematic review found that micro-nanoplastic exposure can trigger epigenetic modifications including chromatin remodeling and miRNA modulation, with potential effects on the KSR-ERK-MAPK, FOXO-Insulin, and GPX3-HIF-alpha pathways in humans. These epigenetic changes could disrupt glucose balance, apoptosis, cell proliferation, and immune function, and may be heritable through mitosis, raising concerns about transgenerational health effects.
Untoward Effects of Micro- and Nanoplastics: An Expert Review of Their Biological Impact and Epigenetic Effects
This expert review examined the biological and epigenetic effects of micro- and nanoplastics on living organisms. The study suggests that while intestinal uptake of plastic particles appears relatively low and size-dependent, nanoplastics may dysregulate molecular signaling pathways, alter gut microbiota composition, and induce transgenerational epigenetic changes potentially linked to metabolic disorders.
Nanoplastics: Focus on the role of microRNAs and long non-coding RNAs
This review explored how nanoplastics may affect gene expression through epigenetic mechanisms, focusing on their potential to alter microRNA and long non-coding RNA regulation, which could contribute to chronic diseases including cancer.
Changes in global methylation patterns of Mytilus galloprovincialis exposed to microplastics
Researchers found that exposing mussels to polystyrene microplastics caused changes in their DNA methylation patterns, an epigenetic modification that controls how genes are turned on and off. Higher microplastic concentrations led to greater loss of methylation, and similar patterns were seen in wild mussels from polluted areas. This suggests microplastics could affect organisms at the genetic regulation level, potentially influencing metabolism and cell division.
Genotoxicity and Genomic Instability Induced by Micro- and Nanoplastics: A Comprehensive Multi-Taxa Mechanistic Review.
This review of existing research found that tiny plastic particles (microplastics and nanoplastics) can damage DNA in many different living things, from fish to human cells. The plastic particles cause this damage by creating harmful molecules called free radicals, disrupting the body's ability to repair DNA, and triggering inflammation. These findings suggest that the growing amount of plastic pollution in our environment could pose serious health risks to humans and wildlife.
Oncogenic Role of miRNA by Environmental Exposure to Plasticizers: A Systematic Review.
This systematic review summarizes recent findings on how exposure to plasticizers can alter microRNA expression in ways that promote cancer development. The research is directly relevant to microplastic concerns because plasticizers are chemical additives used in plastic manufacturing, and as microplastics break down in the body, these chemicals may be released and affect gene regulation.
Environmental Xenobiotics and Epigenetic Modifications: Implications for Human Health and Disease
This review examines how environmental pollutants, including microplastics, can change gene activity through epigenetic modifications without altering DNA itself. These changes to how genes are turned on and off can contribute to cancer, brain diseases, and developmental problems, and may even be passed down to future generations. The research highlights that microplastics and other common pollutants could have long-lasting health effects that go beyond direct chemical toxicity.
The geno-toxicological impacts of microplastic (MP) exposure on health: mechanistic pathways and research trends from a Chinese perspective
This review examines the genotoxic effects of microplastics including DNA damage, oxidative stress, and inflammation pathways that may contribute to carcinogenesis, while analyzing global research trends with a focus on contributions from China.
Effects of Micro‐ and Nanoplastics on Human Genome
This review examines the emerging evidence on how micro- and nanoplastics may interact with human genetic material, including potential effects on DNA integrity and gene expression. Researchers surveyed laboratory studies showing that these particles can induce oxidative stress and inflammatory responses in human cells, which are known pathways for genetic damage. The study highlights significant knowledge gaps and calls for more research into the long-term genomic effects of chronic microplastic exposure.
Investigating the Epigenetic Effects of Polystyrene Nanoplastic Exposure in Bluegill (Lepomis macrochirus) Epithelial Cells Using Methylation-Sensitive AFLPs
Researchers exposed bluegill fish cells to polystyrene nanoplastics and examined whether the exposure caused changes in DNA methylation, a type of genetic modification that can alter how genes function. They found that nanoplastic exposure did cause methylation changes across the genome, but the effect was not dependent on dose or exposure time -- simply being exposed to nanoplastics was enough to trigger the changes. The findings suggest that even low-level nanoplastic exposure could have epigenetic effects on aquatic organisms.
Micro(nano)plastics pollution and human health: How plastics can induce carcinogenesis to humans?
This review examines how microplastics and nanoplastics enter the human body through food, water, and air, and how they may contribute to cancer development. Common plastic types like polystyrene and PVC, along with toxic chemicals they carry such as PAHs and PCBs, have been linked to DNA damage, oxidative stress, and inflammation, all of which can promote cancer. The paper highlights that while the evidence is growing, more research is needed to understand the full cancer risk from chronic microplastic exposure.
Epigenetic Modifications and Gene Expression Alterations in Plants Exposed to Nanomaterials and Nanoplastics: The Role of MicroRNAs, lncRNAs and DNA Methylation
This review examines how nanomaterials and nanoplastics alter plant gene expression through epigenetic mechanisms, focusing on changes in microRNA, long non-coding RNA, and DNA methylation patterns that could disrupt normal plant development and stress responses.
Insights into the potential carcinogenicity of micro- and nano-plastics.
This review examined existing evidence on the carcinogenic potential of micro- and nano-plastics, finding studies demonstrating genotoxicity, oxidative DNA damage, disruption of cell signaling, and tumor-promoting effects, while noting that direct human carcinogenicity data remain limited and mechanistic pathways require further investigation.
Mikroplastik sebagai Kontaminan Anyar dan Efek Toksiknya terhadap Kesehatan
This Indonesian review examines microplastic definition, formation, accumulation, toxicokinetics, and potential pathological effects in humans, with emphasis on biomolecular mechanisms. The authors call for Indonesian healthcare personnel to increase their knowledge of microplastic exposure routes and health implications given Indonesia's status as a major plastic-producing maritime nation.
Rising Concern About the Carcinogenetic Role of Micro‐Nanoplastics
This review raised concerns about the carcinogenic potential of micro- and nanoplastics, synthesizing evidence that these particles can induce DNA damage, oxidative stress, and cellular transformation. It called for accelerated research into whether microplastic exposure increases human cancer risk.
Keberadaan Plastik di Lingkungan, Bahaya terhadap Kesehatan Manusia, dan Upaya Mitigasi: Studi Literatur
This Indonesian-language literature review examined microplastic presence in the environment, summarizing health risks to humans from microplastic exposure through food and water, the environmental fate of plastic particles, and mitigation strategies including the 3Rs and material substitution to reduce plastic waste pollution.
Bioeffects of Nanoplastics: DNA Damage and Mechanism
This review examines how nanoplastics, plastic particles smaller than one micrometer, can damage DNA in cells. The authors explain that nanoplastics may cause genetic damage through oxidative stress, inflammation, and direct interference with cellular processes, which raises concerns about potential long-term health effects including cancer risk.
Nuclear and Mitochondrial Epigenetic Mechanisms Underlying Neurodegeneration and Gut–Brain Axis Dysregulation Induced by Micro- and Nanoplastics
This review explored how micro- and nanoplastics may drive neurodegeneration through epigenetic changes in both nuclear and mitochondrial DNA. Researchers found that plastic particles can disrupt the gut-brain axis, alter DNA methylation and histone modifications, and potentially accelerate neurodegenerative processes, though the study notes these mechanisms are still being characterized in experimental models.
Microplastic exposure is associated with epigenomic effects in the model organism Pimephales promelas (fathead minnow)
Researchers exposed fathead minnows to microplastics and found changes in DNA methylation -- a chemical modification that controls which genes are turned on or off -- across multiple organs including the brain, liver, and gonads. These epigenetic changes are heritable, meaning microplastic exposure could affect not just the exposed fish but also future generations, raising concerns about long-term ecological and evolutionary impacts.