We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Systematic Review: Efek Nanoplastik terhadap Metilasi DNA pada Manusia
AI summary Read the abstract
This systematic review, written in Indonesian, examines how nanoplastics may affect DNA methylation in humans — a process that controls which genes are turned on or off. Changes in DNA methylation can influence disease risk, including cancer. The review highlights an important but understudied pathway through which tiny plastic particles could affect human health at the genetic level.
Latar Belakang: Seiring dengan perkembangan zaman, polusi akan plastik menjadi semakin meningkat dan hal ini menjadi masalah di seluruh dunia terutama di negara yang berkembang akibat jumlahnya yang sangat besar, sifatnya yang persisten, serta penggunaannya yang meluas. Tujuan: Tujuan penulisan systematic review ini adalah untuk mengetahui efek nanoplastik terhadap metilasi deoxyribonucleic acid (DNA) pada manusia. Metode: Metode yang digunakan adalah PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses). Pencarian data berupa artikel atau jurnal dilakukan dengan menggunakan kata kunci “nanoplastics” dan “DNA methylation”. Kriteria inklusi yang digunakan adalah populasi manusia, efek nanoplastik, jenis nanoplastik, jumlah serta waktu paparan, dan metilasi DNA. Sumber data yang digunakan berasal dari google scholar, dengan tahun publikasi dimulai dari tahun 2017-2022, dan bahasa yang digunakan adalah bahasa inggris Ulasan: Total data berdasarkan pencarian menggunakan kata kunci “nanoplastics” dan “DNA Methylation” (n=94), fokus pada artikel kajian dan penelitian serta free full text dengan tahun publikasi adalah 5 tahun terakhir (n=29), kemudian disesuaikan kriteria inklusi (n=13). Kesimpulan: Menurut hasil systematic review didapatkan kesimpulan bahwa terdapat hubungan antara nanoplastik dan metilasi DNA. Namun, hasil ini memiliki keterbatasan sehingga perlu dilakukan riset dengan subjek yang berfokus pada pekerja. Selain itu, systematic review ini belum dapat menjelaskan efek khusus pada pekerja di bidang industri karena keterbatasan literatur yang didapatkan.
More Papers Like This
Nanoplastics as Epigenetic Disruptors: A Biochemical Review of Environmental Pollutants and Gene Regulation
AI summary Read the abstract
This biochemical review examined how nanoplastics disrupt epigenetic regulation, focusing on their ability to alter DNA methylation patterns, histone modifications, and non-coding RNA expression. The authors argued that nanoplastic-induced epigenetic changes could have lasting developmental and health consequences, especially during vulnerable life stages.
Beyond genetics: can micro and nanoplastics induce epigenetic and gene-expression modifications?
AI summary Read the abstract
This review gathers existing research on whether micro and nanoplastics can cause epigenetic changes, which are modifications that alter how genes work without changing the DNA itself. Although studies are still limited, the evidence so far shows that both short-term and long-term plastic particle exposure can trigger these gene-level changes in various organisms. This is concerning because epigenetic changes can potentially be passed to future generations and may contribute to disease.
A systematic review on the impact of micro-nanoplastics on human health: Potential modulation of epigenetic mechanisms and identification of biomarkers
AI summary Read the abstract
This systematic review found that micro-nanoplastic exposure can trigger epigenetic modifications including chromatin remodeling and miRNA modulation, with potential effects on the KSR-ERK-MAPK, FOXO-Insulin, and GPX3-HIF-alpha pathways in humans. These epigenetic changes could disrupt glucose balance, apoptosis, cell proliferation, and immune function, and may be heritable through mitosis, raising concerns about transgenerational health effects.
Untoward Effects of Micro- and Nanoplastics: An Expert Review of Their Biological Impact and Epigenetic Effects
AI summary Read the abstract
This expert review examined the biological and epigenetic effects of micro- and nanoplastics on living organisms. The study suggests that while intestinal uptake of plastic particles appears relatively low and size-dependent, nanoplastics may dysregulate molecular signaling pathways, alter gut microbiota composition, and induce transgenerational epigenetic changes potentially linked to metabolic disorders.
Nanoplastics: Focus on the role of microRNAs and long non-coding RNAs
AI summary Read the abstract
This review explored how nanoplastics may affect gene expression through epigenetic mechanisms, focusing on their potential to alter microRNA and long non-coding RNA regulation, which could contribute to chronic diseases including cancer.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.