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Nanoplastics: Focus on the role of microRNAs and long non-coding RNAs

Chemosphere 2022 20 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Zarrin Banikazemi, Mojgan Farshadi, Mojgan Farshadi, Zarrin Banikazemi, Ali Rajabi, Mina Homayoonfal, Reza Sharafati Chaleshtori Nasrin Sharifi, Reza Sharafati Chaleshtori

Summary

This review explored how nanoplastics may affect gene expression through epigenetic mechanisms, focusing on their potential to alter microRNA and long non-coding RNA regulation, which could contribute to chronic diseases including cancer.

Study Type In vivo

When plastic objects in our surroundings are degraded, they may produce particles ranging in size from 1 to 100 nm therefore called nanoplastics. The environmental chemicals including nanoplastics may be able to affect biological processes in the nuclear level like altering DNA methylation and regulating microRNAs (miRNAs) as well as long non-coding RNAs (lncRNAs) expression and therefore are implicated in chronic human diseases like neoplasms. The regulatory role of miRNAs and lncRNAs in gene expression is appreciated. In vitro as well as in vivo experiments have shown that environmental elements including nanoplastics are able to dysregulate miRNAs and lncRNAs expression with possible genetic consequences that increase the risk of cancer development. In the current article, we review the biological effects of miRNAs and lncRNAs alterations following nanoplastics exposure.

Read via DOI PubMed

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