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61,005 resultsShowing papers similar to Enhanced hepatotoxicity in zebrafish due to co-exposure of microplastics and sulfamethoxazole: Insights into ROS-mediated MAPK signaling pathway regulation
ClearApoptosis, MAPK signaling pathway affected in tilapia liver following nano-microplastics and sulfamethoxazole acute co-exposure
Researchers exposed juvenile tilapia to nano-microplastics combined with the antibiotic sulfamethoxazole and found significant liver damage, including disrupted enzyme activity and inflammatory responses. The combination triggered cell death pathways and stress signaling in liver tissue more severely than either contaminant alone. The study suggests that microplastics may amplify the harmful effects of pharmaceutical pollutants in aquatic environments.
Toxicological mechanisms and molecular impacts of tire particles and antibiotics on zebrafish
Researchers investigated the combined toxic effects of tire microplastics and antibiotics on zebrafish, finding that co-exposure caused more severe damage than either pollutant alone. The combination disrupted liver function, triggered oxidative stress, and altered the expression of genes involved in immune response and metabolism. The study suggests that the widespread co-occurrence of tire particles and antibiotics in waterways may pose compounding risks to aquatic life.
Co-Exposure of Microplastics and Avermectin at Environmental-Related Concentrations Caused Severe Heart Damage Through ROS-Mediated MAPK Signaling in Larval and Adult Zebrafish
Researchers co-exposed zebrafish larvae and adults to polystyrene microplastics and the agricultural pesticide avermectin and assessed cardiac toxicity. Combined exposure caused more severe heart damage than either substance alone, mediated through reactive oxygen species and MAPK signaling, with large microplastics intensifying the cardiotoxic effect of avermectin.
Polyethylene microplastic exposure and concurrent effect with Aeromonas hydrophila infection on zebrafish
Researchers found that polyethylene microplastic exposure in zebrafish caused oxidative stress, altered antioxidant enzyme activity, and induced intestinal damage, with concurrent Aeromonas hydrophila infection amplifying these toxic effects and increasing mortality rates.
Biotransformation and oxidative stress markers in yellowfin seabream (Acanthopagrus latus): Interactive impacts of microplastics and florfenicol
Researchers studied how microplastics interact with the antibiotic florfenicol to affect detoxification enzymes and oxidative stress in yellowfin seabream. They found that combined exposure to both pollutants caused more pronounced liver damage and oxidative stress than either substance alone, and that recovery took longer. The study suggests that microplastics can worsen the toxic effects of antibiotics used in aquaculture.
Hepatotoxicity, developmental toxicity, and neurotoxicity risks associated with co-exposure of zebrafish to fluoroquinolone antibiotics and tire microplastics: An in silico study
Using computer modeling, this study found that tire microplastics combined with common antibiotics caused significantly more liver damage in zebrafish than brain or developmental harm. The two pollutants worked together to amplify toxicity, meaning the combination was worse than either one alone. This highlights how microplastics in waterways can interact with other contaminants to create greater health risks for aquatic life and potentially for humans who consume seafood.
Biological toxicity of sulfamethoxazole in aquatic ecosystem on adult zebrafish (Danio rerio)
Not relevant to microplastics — this study examines how the antibiotic sulfamethoxazole affects zebrafish health, finding that chronic exposure causes liver and gill oxidative damage and disrupts gut bacteria, with no focus on plastic pollution.
Microplastic-contaminated antibiotics as an emerging threat to mammalian liver: enhanced oxidative and inflammatory damages
Researchers used a mouse model to study what happens when microplastics contaminated with antibiotics are ingested together, simulating real-world food chain exposure. The study found that the combination caused enhanced oxidative stress and inflammatory damage in the liver compared to either pollutant alone. The findings suggest that microplastics carrying adsorbed antibiotics may pose a greater threat to liver health than microplastics or antibiotics individually.
Microcystin-LR and polystyrene microplastics jointly lead to hepatic histopathological damage and antioxidant dysfunction in male zebrafish
This study exposed zebrafish to a common water toxin (microcystin-LR) both alone and combined with polystyrene microplastics, and found that the microplastics made the liver damage significantly worse. The microplastics acted as carriers, increasing how much toxin accumulated in the fish liver and amplifying oxidative stress. This is relevant to human health because it shows microplastics can boost the harmful effects of other pollutants commonly found in drinking water sources.
Polystyrene microplastics enhance microcystin-LR-induced cardiovascular toxicity and oxidative stress in zebrafish embryos
Zebrafish embryos exposed to both microplastics and microcystin-LR (a toxin produced by algal blooms) developed significantly worse heart and blood vessel damage than those exposed to the toxin alone. The microplastics amplified oxidative stress and cell death, suggesting that in polluted waterways where both contaminants coexist, the combined health risks may be greater than either one individually.
The interaction between polyethylene microplastics and ciprofloxacin on inducing hepatotoxicity in Carassius auratus via the gut-liver axis
Researchers co-exposed crucian carp to polyethylene microplastics and the antibiotic ciprofloxacin and assessed liver toxicity through the gut-liver axis. The combination caused greater hepatic injury than either contaminant alone—disrupting gut microbiota, increasing intestinal permeability, and amplifying liver inflammation—highlighting synergistic toxicity when fish are exposed to both antibiotic and plastic pollution.
Toxicological effects of microplastics and phenanthrene to zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene microplastics, the pollutant phenanthrene, and a combination of both to assess their toxicity over 24 days. They found that co-exposure amplified oxidative stress, suppressed immune gene expression, and significantly disrupted the gut microbiome compared to either contaminant alone. The study suggests that microplastics can worsen the toxic effects of organic pollutants in aquatic organisms by altering how chemicals accumulate and interact in the body.
Microbead-Mediated Enhancement of Bacterial Toxicity: Oxidative Stress and Apoptosis in Korean Rockfish, Sebastes schlegeli, Following Exposure to Streptococcus iniae
Korean rockfish were co-exposed to polystyrene microbeads and the bacterium Streptococcus iniae for five days, and oxidative stress and apoptosis were measured in liver tissue. Combined high-dose exposure significantly elevated oxidative stress markers and caspase-3 expression compared to either stressor alone, suggesting microplastics may enhance bacterial infection severity.
Biomicroplastics and Antibiotics: A Toxic Cocktail for Fatty Liver Disease in Marine Medaka.
Marine medaka fish co-exposed to aged polylactic acid (PLA) biomicroplastics and the antibiotic sulfamethazine developed fatty liver disease more severely than with either contaminant alone, demonstrating synergistic toxicity. The study highlighted that bioplastic debris combined with antibiotics poses a serious health threat to marine organisms.
Co-exposure to polystyrene microplastics and cypermethrin enhanced the effects on hepatic phospholipid metabolism and gut microbes in adult zebrafish
When zebrafish were exposed to both polystyrene microplastics and the pesticide cypermethrin together, the combination caused significantly more liver damage than either pollutant alone. The mixture disrupted fat metabolism in the liver and altered gut bacteria in ways not seen with individual exposures. This matters because microplastics and pesticides frequently co-exist in waterways, and their combined effects on fish health could affect the safety of fish as food.
Methamphetamine Shows Different Joint Toxicity for Different Types of Microplastics on Zebrafish Larvae by Mediating Oxidative Stress
This study examined the joint toxicity of polystyrene and polypropylene microplastics combined with methamphetamine on zebrafish larvae, finding that the drug altered microplastic toxicity in a type-dependent manner via oxidative stress pathways. The results highlight the complexity of combined pollutant exposures in aquatic environments.
Nanoplastics enhance the intestinal damage and genotoxicity of sulfamethoxazole to medaka juveniles (Oryzias melastigma) in coastal environment
Scientists exposed young medaka fish to the antibiotic sulfamethoxazole and polystyrene nanoplastics, both individually and together, to study their combined effects on intestinal health. They found that co-exposure caused more severe gut damage than either pollutant alone, disrupting the gut microbiome and triggering changes in gene expression related to immune defense and DNA repair. The study suggests that nanoplastics may amplify the harmful effects of antibiotics on fish in coastal environments.
Co-exposure to microplastics and tire particles exacerbates oxidative stress and gut microbiome dysbiosis in zebrafish (Danio rerio)
Researchers exposed zebrafish for 21 days to environmentally relevant mixtures of microplastics and tire particles and found that combined exposure caused more severe oxidative stress and gut microbiome disruption than either pollutant alone. Particle accumulation occurred mainly in the gut with secondary deposition in the liver, and the most pronounced tissue damage was observed under the highest combined exposure. Gut microbiota analysis revealed significant shifts in community structure, including reduced beneficial bacteria and increased pollutant-tolerant species.
Microplastics Enhance the Toxic Effects of Tetracycline on the Early Development of Zebrafish in a Dose-Dependent Manner
Researchers exposed zebrafish embryos and larvae to polyethylene microplastics combined with the antibiotic tetracycline and found that the combination enhanced toxic effects in a dose-dependent manner. The co-exposure caused increased mortality, reduced body length, cardiac abnormalities, and aberrant vascular development through mechanisms involving oxidative stress and inflammation. The findings demonstrate that microplastics can amplify the toxicity of antibiotics during critical early developmental stages in fish.
Combined effects of microplastics and copper on oxidative responses in zebrafish (Danio rerio)
Researchers exposed zebrafish (Danio rerio) to microplastics (10 µg/L) and copper (45 µg/L) individually and in combination, finding that fish exposed to both stressors simultaneously exhibited higher oxidative stress across multiple body organs than those exposed to either contaminant alone.
Toxic Effects of Polystyrene Microplastics and Sulfamethoxazole on Early Neurodevelopment in Embryo–Larval Zebrafish (Danio rerio)
Researchers exposed embryo-larval zebrafish to polystyrene microplastics and the antibiotic sulfamethoxazole to assess their individual and combined effects on early neurodevelopment. The study found that both contaminants individually caused neurodevelopmental toxicity, and their combination produced a significant synergistic effect, suggesting that co-exposure to microplastics and antibiotics may pose greater risks than either pollutant alone.
Accumulation and ecotoxicological effects induced by combined exposure of different sized polyethylene microplastics and oxytetracycline in zebrafish
Researchers conducted a 30-day experiment exposing zebrafish to different sized polyethylene microplastics combined with the antibiotic oxytetracycline. They found that smaller nanoplastics increased antibiotic accumulation in fish liver by up to 44.5%, and the combined exposure caused more severe liver damage than either contaminant alone, with effects worsening as particle size decreased. The study suggests that microplastics can amplify the toxicity of antibiotics in aquatic organisms through enhanced bioaccumulation.
Toxicity evaluation of the combination of emerging pollutants with polyethylene microplastics in zebrafish: Perspective study of genotoxicity, mutagenicity, and redox unbalance
Researchers exposed adult zebrafish to polyethylene microplastics combined with a mixture of common water pollutants for 15 days and assessed DNA damage, mutation rates, and oxidative stress. They found that microplastics alone caused DNA damage and nuclear abnormalities as severe as those caused by the pollutant mixture, challenging the assumption that microplastics are less harmful than chemical contaminants. The study revealed that the fish's antioxidant defenses were overwhelmed across multiple organs, suggesting widespread oxidative damage from microplastic exposure.
Rainbow trout (Oncorhynchus mykiss) physiological response to microplastics and enrofloxacin: Novel pathways to investigate microplastic synergistic effects on pharmaceuticals
Scientists studied how microplastics interact with the antibiotic enrofloxacin in rainbow trout and found that the combination increased toxicity beyond what either pollutant caused alone. The microplastics appeared to change how the antibiotic was absorbed and processed in the fish, leading to greater liver damage and immune system disruption. Since fish are exposed to both pollutants in real waterways, this synergistic toxicity could affect seafood safety and the health of people who consume contaminated fish.