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Apoptosis, MAPK signaling pathway affected in tilapia liver following nano-microplastics and sulfamethoxazole acute co-exposure

Comparative Biochemistry and Physiology Part D Genomics and Proteomics 2024 8 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Yao Zheng, Yao Zheng, Yao Zheng, Yao Zheng, Yao Zheng, Yao Zheng, Yao Zheng, Yao Zheng, Haojun Zhu, Haojun Zhu, Jiawen Hu, Jiawen Hu, Jiajia Li, Jiajia Li, Jiajia Li, Jiajia Li, Jiawen Hu, Gangchun Xu, Haojun Zhu, Jiancao Gao Jiancao Gao Jiancao Gao Haojun Zhu, Jiawen Hu, Jiawen Hu, Jiawen Hu, Gangchun Xu, Jiancao Gao Wei� Jin, Wei� Jin, Jiawen Hu, Yi Sun, Yi Sun, Gangchun Xu, Gangchun Xu, Gangchun Xu, Jiawen Hu, Jiawen Hu, Jiawen Hu, Yi Sun, Haojun Zhu, Jiawen Hu, Haojun Zhu, Haojun Zhu, Haojun Zhu, Jiawen Hu, Gangchun Xu, Yi Sun, Yao Zheng, Gangchun Xu, Gangchun Xu, Yi Sun, Yi Sun, Yi Sun, Haojun Zhu, Haojun Zhu, Haojun Zhu, Haojun Zhu, Haojun Zhu, Gangchun Xu, Gangchun Xu, Gangchun Xu, Gangchun Xu, Jiancao Gao

Summary

Researchers exposed juvenile tilapia to nano-microplastics combined with the antibiotic sulfamethoxazole and found significant liver damage, including disrupted enzyme activity and inflammatory responses. The combination triggered cell death pathways and stress signaling in liver tissue more severely than either contaminant alone. The study suggests that microplastics may amplify the harmful effects of pharmaceutical pollutants in aquatic environments.

Body Systems

Hepatic Immune

Models

Fish other

Studies showed that toxicants that adhered to the surface of nano-microplastics (NPs) have toxicological effects. Juvenile tilapia were divided into four groups namely the control group (A), 100 ng·L sulfamethoxazole (SMZ) group (B), 75 nm NPs group (C) and SMZ + 75 nm NPs group (D), and were exposed to an acute test for 2, 4 and 8 days. The hepatic histopathological changes, enzymatic activities, transcriptomics and proteomics analysis have been performed. The results showed that; the enzymatic activities of anti-oxidative enzymes (ROS, SOD, EROD), energy (ATP), lipid metabolism (TC, TG, FAS, LPL, ACC), pro-inflammatory factors (TNFα, IL-1β) and apoptosis (Caspase 3) have decreased significantly at 8 d. Hepatic histopathological results revealed the narrowed hepatic sinuses, displaced nucleus, and vacuoles under SMZ exposure. Transcriptome results demonstrated that endocytosis, MAPK signaling pathway, apoptosis, lysosome and herpes simplex infection were enriched in group C at 8 d. apaf1, casp3a, nfkbiaa (apoptosis, except for 8 d) were significantly increased, il1b and tgfb3, fgfr2 showed significant increase and decrease in group C/D. ctsd and ctsk associated with apoptosis have been especially significantly increased at 8 d, while MAPK signaling pathway, gadd45ga, gadd45gb/gadd45gg have been significantly decreased and increased, as well as map3k3/map3k2 significantly decreased at 8 d. Apoptosis and MAPK signaling pathway were affected and the synergistic effect was verified in tilapia liver following NPs and SMZ acute co-exposure.

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