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Biotransformation and oxidative stress markers in yellowfin seabream (Acanthopagrus latus): Interactive impacts of microplastics and florfenicol
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Researchers studied how microplastics interact with the antibiotic florfenicol to affect detoxification enzymes and oxidative stress in yellowfin seabream. They found that combined exposure to both pollutants caused more pronounced liver damage and oxidative stress than either substance alone, and that recovery took longer. The study suggests that microplastics can worsen the toxic effects of antibiotics used in aquaculture.
This study investigates the combined toxicity of microplastics (MPs) and florfenicol (FLO) on biotransformation enzymes and oxidative stress biomarkers in the liver and kidney of yellowfin seabream (Acanthopagrus latus). Fish were fed 15 mg kg-1 of FLO and 100 or 500 mg kg-1 of MPs for 10 days. Biomarkers, including ethoxyresorufin-O-deethylase, glutathione-S-transferase, superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde (MDA), and protein carbonylation (PC), were measured in both organs at 1, 7, and 14 days post-exposure. FLO levels peaked on day 1 and declined after that. Liver biomarkers were more responsive to pollutants, with the combined exposure of FLO and MPs leading to more pronounced toxicity. By day 14, only the FLO group showed a return to baseline biomarker levels, while MDA and PC levels remained elevated in MPs and co-exposed groups. These findings highlight the importance of considering the interactive effects of multiple pollutants in addressing marine environmental stressors.
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Ecotoxicological assessment of microplastics and florfenicol on Acanthopagrus latus: mucus, humoral immune responses and DNA damage
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Researchers exposed yellowfin seabream to microplastics and the antibiotic florfenicol, both individually and in combination, over a 10-day period. They found that microplastics elevated cholesterol, glucose, and liver enzyme levels while suppressing immune markers in both blood and skin mucus. The combined exposure to microplastics and florfenicol produced more severe and longer-lasting effects than the antibiotic alone.
Effect of Polypropylene Microplastic and Florfenicol Antibiotic on Some Hormonal and Haematological Biomarkers in Yellowfin Seabream (Acanthopagrus latus)
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Researchers studied the combined effects of polypropylene microplastics and the antibiotic florfenicol on blood and hormone markers in yellowfin seabream. They found that exposure to both pollutants together caused more pronounced changes in cortisol, thyroid hormones, and blood cell counts than either substance alone. The study suggests that the co-occurrence of microplastics and antibiotics in marine environments may create compounding health effects in fish.
Rainbow trout (Oncorhynchus mykiss) physiological response to microplastics and enrofloxacin: Novel pathways to investigate microplastic synergistic effects on pharmaceuticals
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Scientists studied how microplastics interact with the antibiotic enrofloxacin in rainbow trout and found that the combination increased toxicity beyond what either pollutant caused alone. The microplastics appeared to change how the antibiotic was absorbed and processed in the fish, leading to greater liver damage and immune system disruption. Since fish are exposed to both pollutants in real waterways, this synergistic toxicity could affect seafood safety and the health of people who consume contaminated fish.
Enhanced hepatotoxicity in zebrafish due to co-exposure of microplastics and sulfamethoxazole: Insights into ROS-mediated MAPK signaling pathway regulation
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Zebrafish exposed to both microplastics and the antibiotic sulfamethoxazole (commonly found in waterways) suffered significantly worse liver damage than exposure to either pollutant alone. The combined exposure triggered a cascade of oxidative stress, inflammation, and cell death in liver tissue, showing how microplastics can amplify the harmful effects of other environmental contaminants.
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Researchers exposed juvenile tilapia to nano-microplastics combined with the antibiotic sulfamethoxazole and found significant liver damage, including disrupted enzyme activity and inflammatory responses. The combination triggered cell death pathways and stress signaling in liver tissue more severely than either contaminant alone. The study suggests that microplastics may amplify the harmful effects of pharmaceutical pollutants in aquatic environments.
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