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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Marine & Wildlife Sign in to save

Biotransformation and oxidative stress markers in yellowfin seabream (Acanthopagrus latus): Interactive impacts of microplastics and florfenicol

The Science of The Total Environment 2024 7 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Mario Alberto Burgos-Aceves, Mario Alberto Burgos-Aceves, Mario Alberto Burgos-Aceves, Caterina Faggio Mehrnaz Shirmohammadi, Mehrnaz Shirmohammadi, Mehrnaz Shirmohammadi, Nima Shiry, Caterina Faggio Farahnaz Kianersi, Farahnaz Kianersi, Farahnaz Kianersi, Caterina Faggio Caterina Faggio Nima Shiry, Caterina Faggio Nima Shiry, Nima Shiry, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Mario Alberto Burgos-Aceves, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Mario Alberto Burgos-Aceves, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio

Summary

Researchers studied how microplastics interact with the antibiotic florfenicol to affect detoxification enzymes and oxidative stress in yellowfin seabream. They found that combined exposure to both pollutants caused more pronounced liver damage and oxidative stress than either substance alone, and that recovery took longer. The study suggests that microplastics can worsen the toxic effects of antibiotics used in aquaculture.

Body Systems
Hepatic Renal

This study investigates the combined toxicity of microplastics (MPs) and florfenicol (FLO) on biotransformation enzymes and oxidative stress biomarkers in the liver and kidney of yellowfin seabream (Acanthopagrus latus). Fish were fed 15 mg kg<sup>-1</sup> of FLO and 100 or 500 mg kg<sup>-1</sup> of MPs for 10 days. Biomarkers, including ethoxyresorufin-O-deethylase, glutathione-S-transferase, superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde (MDA), and protein carbonylation (PC), were measured in both organs at 1, 7, and 14 days post-exposure. FLO levels peaked on day 1 and declined after that. Liver biomarkers were more responsive to pollutants, with the combined exposure of FLO and MPs leading to more pronounced toxicity. By day 14, only the FLO group showed a return to baseline biomarker levels, while MDA and PC levels remained elevated in MPs and co-exposed groups. These findings highlight the importance of considering the interactive effects of multiple pollutants in addressing marine environmental stressors.

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