We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
20 resultsShowing papers similar to Role of dietary nutrients and metabolism in colorectal cancer.
ClearWhy Is Colorectal Cancer Occurring Earlier? Metabolic Dysfunction, Underrecognized Carcinogens, and Emerging Controversies
Researchers reviewed the rising incidence of early-onset colorectal cancer in people under 50, synthesizing epidemiological, molecular, and multi-omics evidence that implicates metabolic dysfunction, accelerated epigenetic aging, gut microbiome dysbiosis, and modern environmental exposures including micro- and nanoplastics as converging contributors to this trend.
Contributing factors common to COVID‑19 and gastrointestinal cancer
This review identifies contributing factors common to COVID-19 vulnerability and gastrointestinal cancer risk, including gut microbiome dysbiosis, dietary patterns, and chronic inflammation, suggesting that immune dysfunction driven by environmental and lifestyle factors underlies susceptibility to both conditions.
The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development
This review explores why colorectal cancer is increasing among younger people, pointing to changes in gut bacteria, diet, and environmental exposures as likely contributors. Microplastics are discussed as one of several environmental factors that may be disrupting the gut microbiome and promoting inflammation linked to cancer development. The findings suggest that the rising tide of environmental contaminants, including microplastics, could be playing a role in this troubling health trend.
The Influence of Ultra-Processed Food on Colorectal Cancer: A Systematic Review
This systematic review of 24 studies found an association between diets high in ultra-processed foods and increased colorectal cancer incidence. The harmful effects are driven by high levels of sugar, fat, red meat, and additives in these foods, compounded by sedentary lifestyles and obesity.
Microplastics and the Rising Tide of Early‐Onset Colorectal Cancer: Exploring the Environmental Gut Connection
This paper explores the potential connection between microplastic exposure and the rising rates of early-onset colorectal cancer. The study discusses how microplastics may interact with the gut environment, suggesting that further research is needed to understand whether environmental microplastic contamination could be contributing to this emerging health trend.
The clinical relevance of microplastic exposure on colorectal cancer: A systematic review
This systematic review of four studies found that microplastic accumulation in colorectal cancer tissue (25.9-32.2 particles/g) was significantly higher than in healthy controls, with polyamide, polycarbonate, and polypropylene as the most common polymers detected. While a causal relationship has not been established, the evidence points to microplastics as a potential environmental factor in colorectal cancer development.
Microplastic Exposure and Its Dual Impact on Metabolic Syndrome and Pathways of Colorectal Carcinogenesis: A Systematic Review of Epidemiological, Experimental, and Mechanistic Evidence
This systematic review examines evidence linking microplastic exposure to both metabolic syndrome and colorectal cancer pathways. It found a biologically plausible connection between microplastic exposure and these conditions, though a direct clinical link to cancer has not yet been established.
Orally Ingested Micro- and Nano-Plastics: A Hidden Driver of Inflammatory Bowel Disease and Colorectal Cancer.
This review synthesizes evidence linking ingested micro- and nano-plastics to inflammatory bowel disease and colorectal cancer risk, proposing that microplastics act as a hidden driver of gut inflammation in vulnerable populations. The authors argue that intestinal accumulation of microplastics triggers immune and oxidative stress pathways that contribute to disease progression.
Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer
Researchers examined tumor and surrounding tissue from colorectal cancer patients and found a diverse range of microplastics, including PVC and polyethylene, with tumor tissues containing a greater variety and higher distribution of microplastics than adjacent healthy tissue. A protein called clathrin that helps cells absorb materials was highly active in the cancer tissue, suggesting it may facilitate microplastic uptake and pointing to a potential link between microplastic exposure and colorectal cancer development.
Microplastics and Colorectal Cancer: Presence in Human Colorectal Tissues and Associations with Tumor Biology- A Systematic Review
This review of 13 studies found that tiny plastic particles called microplastics are present in human colon tissues, with higher amounts found in cancerous tumors compared to healthy tissue. The research suggests these plastic particles may contribute to colon cancer development by causing inflammation and creating conditions that help tumors grow. While more research is needed to prove a direct cause-and-effect relationship, this highlights growing concerns about how plastic pollution in our environment and food supply might affect human health.
Chemoprophylaxis of precancerous lesions in patients who are at a high risk of developing colorectal cancer (Review)
This review covers chemoprevention strategies for precancerous lesions in patients at elevated cancer risk, evaluating evidence for pharmacological and dietary interventions including natural compounds that modulate carcinogenic pathways. The authors assess clinical trial evidence and identify specific compounds with strong evidence for reducing progression from precancerous to malignant lesions.
Invisible invaders: unveiling the carcinogenic threat of microplastics and nanoplastics in colorectal cancer-a systematic review
This systematic review examines the potential link between microplastics and nanoplastics and colorectal cancer. The research highlights how these tiny particles may contribute to cancer development through mechanisms like chronic inflammation and cellular damage in the gut. While more studies are needed, the findings raise important questions about the long-term consequences of ingesting plastic particles.
Microplastics: An emerging environmental risk factor for gut microbiota dysbiosis and cancer development?
This review examines how microplastics may disrupt the gut microbiome and immune system in ways that could promote cancer development. Evidence from recent studies suggests microplastics can cause chronic inflammation, alter the balance of gut bacteria, and trigger molecular pathways linked to several cancer types including lung, liver, breast, and colon cancer. While more human research is needed, the review highlights a concerning connection between microplastic exposure, gut health, and cancer risk.
Pollutants, microbiota and immune system: frenemies within the gut
This review summarizes how environmental pollutants, including microplastics, disrupt the gut microbiome and immune system, potentially contributing to inflammatory bowel diseases and colorectal cancer. Pollutants reduce beneficial gut bacteria while promoting inflammation, weakening the intestinal barrier, and triggering a chain of events that can push cells toward cancerous growth.
Elevated levels of serum glucose, triglyceride, and liver enzymes in a rat model of 7,12 dimethylbenz[a]anthracene (DMBA)-induced carcinogenesis
Researchers found elevated serum glucose, triglyceride, and liver enzyme levels in a rat model of chemically induced carcinogenesis using DMBA, providing insight into how tumor development alters systemic metabolism and energy substrate utilization in cancer progression.
Microplastics as Emerging Contaminants and Human Health: Exploring Functional Nutrition in Gastric–Colon–Brain Axis Cancer
This review explores how microplastics may increase cancer risk along the stomach-colon-brain pathway by triggering oxidative stress, inflammation, and disrupting cell signaling. The paper also highlights that certain plant-based nutrients and flavonoids may help protect cells from microplastic damage by activating the body's detoxification pathways, suggesting functional nutrition could be a strategy to reduce harm from plastic exposure.
In vitro evidence and integrative bioinformatics identify the SGLT2-PPARγ axis as a target against polyethylene microplastic-driven metabolic reprogramming in colorectal cancer cells
Researchers used in vitro experiments and bioinformatics to identify the SGLT2-PPARgamma axis as a molecular target affected by polyethylene microplastic exposure in colorectal cancer cells. The study suggests that microplastics may influence metabolic reprogramming in cancer cells, highlighting a potential interplay between environmental pollutants and metabolic regulation.
Cancer and Food-Related Risks: A Review
This review examines the relationship between diet, food-related environmental exposures, and cancer risk, covering evidence for carcinogenic dietary patterns, contaminants in food including persistent organic pollutants and heavy metals, and the emerging concern of microplastics as potential carcinogens. The authors emphasize that dietary risk is multi-factorial and that improving food safety standards remains a key prevention lever.
Could Microplastics Be a Driver for Early Onset Colorectal Cancer?
This paper explores whether microplastics could be contributing to the rising rates of colorectal cancer in people under 50. The timing of this increase lines up with the mass production of plastics starting in the 1950s, and microplastics are known to disrupt the gut lining and interact with gut bacteria in ways that could promote cancer. While not proven, the authors argue this connection deserves urgent research given how much plastic humans now ingest.
Exploring the prognostic implications of PET microplastic degradation products in colorectal cancer: insights from an integrated computational analysis on glucocorticoid pathway–mediated mechanisms
This computational study investigated how PET microplastic degradation products affect colorectal cancer prognosis, identifying 43 genes linking ethylene glycol and terephthalic acid exposure to cancer pathogenesis via chronic inflammation mediated through TNF/IL-17 and glucocorticoid metabolic pathways.