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The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development
Summary
This review explores why colorectal cancer is increasing among younger people, pointing to changes in gut bacteria, diet, and environmental exposures as likely contributors. Microplastics are discussed as one of several environmental factors that may be disrupting the gut microbiome and promoting inflammation linked to cancer development. The findings suggest that the rising tide of environmental contaminants, including microplastics, could be playing a role in this troubling health trend.
Traditionally considered a disease common in the older population, colorectal cancer is increasing in incidence among younger demographics. Evidence suggests that populational- and generational-level shifts in the composition of the human gut microbiome may be tied to the recent trends in gastrointestinal carcinogenesis. This review provides an overview of current research and putative mechanisms behind the rising incidence of colorectal cancer in the younger population, with insight into future interventions that may prevent or reverse the rate of early-onset colorectal carcinoma.
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