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Microplastic Exposure and Its Dual Impact on Metabolic Syndrome and Pathways of Colorectal Carcinogenesis: A Systematic Review of Epidemiological, Experimental, and Mechanistic Evidence

Journal of Toxicology 2025
Abdullah Faisal Albukhari

Summary

This systematic review examines evidence linking microplastic exposure to both metabolic syndrome and colorectal cancer pathways. It found a biologically plausible connection between microplastic exposure and these conditions, though a direct clinical link to cancer has not yet been established.

Models
Study Type Review

The results indicate a biologically plausible connection between MP exposure and the development of both MetS and colorectal carcinogenesis pathways, rather than a direct clinical association with early-onset colorectal cancer.

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