We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Role of dietary nutrients and metabolism in colorectal cancer.
Summary
This review examines how dietary nutrients including glucose, amino acids, lipids, vitamins, and prebiotics may influence colorectal cancer risk and progression. The study discusses metabolic interactions between tumor cells, the tumor microenvironment, and gut microbiota, suggesting that nutritional factors play a meaningful role in shaping these complex biological processes.
Colorectal cancer (CRC) is one of the most common malignancies and the leading causes of cancer related deaths worldwide. The development of CRC is driven by a combination of genetic and environmental factors. There is growing evidence that changes in dietary nutrition may modulate the CRC risk, and protective effects on the risk of developing CRC have been advocated for specific nutrients such as glucose, amino acids, lipid, vitamins, micronutrients and prebiotics. Metabolic crosstalk between tumor cells, tumor microenvironment components and intestinal flora further promote proliferation, invasion and metastasis of CRC cells and leads to treatment resistance. This review summarizes the research progress on CRC prevention, pathogenesis, and treatment by dietary supplementation or deficiency of glucose, amino acids, lipids, vitamins, micronutri-ents, and prebiotics, respectively. The roles played by different nutrients and dietary crosstalk in the tumor microenvironment and metabolism are discussed, and nutritional modulation is inspired to be beneficial in the prevention and treatment of CRC.
Sign in to start a discussion.
More Papers Like This
Why Is Colorectal Cancer Occurring Earlier? Metabolic Dysfunction, Underrecognized Carcinogens, and Emerging Controversies
Researchers reviewed the rising incidence of early-onset colorectal cancer in people under 50, synthesizing epidemiological, molecular, and multi-omics evidence that implicates metabolic dysfunction, accelerated epigenetic aging, gut microbiome dysbiosis, and modern environmental exposures including micro- and nanoplastics as converging contributors to this trend.
Contributing factors common to COVID‑19 and gastrointestinal cancer
This review identifies contributing factors common to COVID-19 vulnerability and gastrointestinal cancer risk, including gut microbiome dysbiosis, dietary patterns, and chronic inflammation, suggesting that immune dysfunction driven by environmental and lifestyle factors underlies susceptibility to both conditions.
The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development
This review explores why colorectal cancer is increasing among younger people, pointing to changes in gut bacteria, diet, and environmental exposures as likely contributors. Microplastics are discussed as one of several environmental factors that may be disrupting the gut microbiome and promoting inflammation linked to cancer development. The findings suggest that the rising tide of environmental contaminants, including microplastics, could be playing a role in this troubling health trend.
The Influence of Ultra-Processed Food on Colorectal Cancer: A Systematic Review
This systematic review of 24 studies found an association between diets high in ultra-processed foods and increased colorectal cancer incidence. The harmful effects are driven by high levels of sugar, fat, red meat, and additives in these foods, compounded by sedentary lifestyles and obesity.
Microplastics and the Rising Tide of Early‐Onset Colorectal Cancer: Exploring the Environmental Gut Connection
This paper explores the potential connection between microplastic exposure and the rising rates of early-onset colorectal cancer. The study discusses how microplastics may interact with the gut environment, suggesting that further research is needed to understand whether environmental microplastic contamination could be contributing to this emerging health trend.