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Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer
Summary
Researchers examined tumor and surrounding tissue from colorectal cancer patients and found a diverse range of microplastics, including PVC and polyethylene, with tumor tissues containing a greater variety and higher distribution of microplastics than adjacent healthy tissue. A protein called clathrin that helps cells absorb materials was highly active in the cancer tissue, suggesting it may facilitate microplastic uptake and pointing to a potential link between microplastic exposure and colorectal cancer development.
The widespread occurrence of microplastics (MPs) in the environment has raised significant concerns regarding their potential health impacts, particularly in relation to carcinogenesis. This study aimed to identify and analyze microplastics present in peritumoral and tumor tissues of patients diagnosed with colorectal cancer (CRC). Utilizing advanced scanning electron microscopy (SEM) and laser direct infrared (LDIR) imaging systems, we systematically examined tissue samples to detect and characterize the microplastics. Our findings revealed a diverse array of microplastic types, notably polyvinyl chloride (PVC) and polyethylene (PE), within both peritumoral and tumor regions. Compared to adjacent non-cancerous tissues, tumor tissues exhibited a greater variety and distribution of microplastics. Furthermore, Clathrin-a key protein involved in endocytosis-was found to be highly expressed in colorectal cancer specimens, facilitating the substantial uptake of microplastics. These results suggest a potential association between exposure to microplastics and the pathogenesis of colorectal cancer. This study highlights the urgent need for increased awareness and regulatory measures aimed at mitigating microplastic pollution along with its associated health risks.