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In vitro evidence and integrative bioinformatics identify the SGLT2-PPARγ axis as a target against polyethylene microplastic-driven metabolic reprogramming in colorectal cancer cells

Journal of Translational Medicine 2026
Isabella Donisi, Isabella Donisi, Celestino Sardu, Antonino Colloca, Anna Balestrieri, Vitale Del Vecchio, Vitale Del Vecchio, Raffaele Marfella, A. Coletta, Giuseppe Campanile, Nunzia D’Onofrio, Nunzia D’Onofrio, Maria Luisa Balestrieri, Maria Luisa Balestrieri

Summary

Researchers used in vitro experiments and bioinformatics to identify the SGLT2-PPARgamma axis as a molecular target affected by polyethylene microplastic exposure in colorectal cancer cells. The study suggests that microplastics may influence metabolic reprogramming in cancer cells, highlighting a potential interplay between environmental pollutants and metabolic regulation.

Polymers
PE
Study Type In vitro

Results unveil the adverse effects of PE on CRC progression underscoring a dynamic interplay between environmental pollutants, metabolic regulators and dietary bioactive modulators. This evidence lay the groundwork for future studies on integrative approaches aimed at mitigating the effects of microplastic pollution on CRC.

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