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61,005 resultsShowing papers similar to Impact of dietary exposure to polyester microfibers on hematology, serology and histology in a mouse model
ClearHemotoxic effects of polyethylene microplastics on mice
Researchers exposed mice to different concentrations of polyethylene microplastics for 15 days and studied the effects on their blood. The highest dose caused significant damage to red blood cells, leading to abnormal shapes and reduced blood cell counts, along with impaired liver and kidney function. The study suggests that microplastic exposure may have harmful effects on blood health in mammals, including patterns consistent with anemia.
Microplastics exposure altered hematological and lipid profiles as well as liver and kidney function parameters in albino rats (Rattus norvegicus)
Researchers fed albino rats different concentrations of microplastics for 28 days and measured changes in blood, liver, kidney, and lipid profiles. They found dose-dependent effects including reduced immune cell counts suggesting immunosuppression, lower red blood cell levels indicating anemia, and altered liver and kidney function markers. The study provides evidence that microplastic ingestion may affect multiple organ systems and blood health in a way that worsens with higher exposure levels.
The effect of polystyrene foam in different doses on the blood parameters and relative mass of internal organs of white mice
Researchers fed white mice different doses of polystyrene foam over 42 days and found dose-dependent changes in blood biochemical parameters and relative organ masses, providing evidence that ingested microplastics affect metabolism and internal organ function in mammals.
Hematological consequences of polyethylene microplastics toxicity in male rats: Oxidative stress, genetic, and epigenetic links
Researchers gave male rats different doses of polyethylene microplastics orally for 35 days and found significant damage to blood cells and the blood-forming system. Higher doses caused oxidative stress, DNA damage, and changes in gene expression patterns related to blood cell production. The study suggests that chronic microplastic ingestion could harm the blood system through both genetic and epigenetic pathways.
Dose‐Dependent Toxicological Effects of Polyvinyl Chloride and Polystyrene Microplastics on Wistar Albino Rats
Researchers fed rats PVC and polystyrene microplastics at different doses for eight weeks and observed significant changes including weight loss, elevated blood glucose, increased cholesterol and liver enzymes, and signs of oxidative stress. The study suggests that oral microplastic exposure at these levels can cause dose-dependent toxicological effects across multiple organ systems in mammals.
Hepatic and metabolic outcomes induced by sub-chronic exposure to polystyrene microplastics in mice
Researchers studied the effects of sub-chronic polystyrene microplastic exposure on mouse livers using multiple analytical approaches. They found that microplastics accumulated in liver tissue and caused inflammation, oxidative stress, and disruption of normal metabolic processes including lipid and amino acid metabolism. The study suggests that prolonged microplastic ingestion may pose significant risks to liver health.
Subacute PVC Microplastic Inhalation Alters the Complete Blood Count Profile
Researchers exposed mice to PVC microplastics via inhalation over a subacute period and measured changes in complete blood count parameters. Inhalation caused significant alterations in blood cell profiles, indicating that inhaled PVC microplastics provoke a systemic hematological response.
Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure
Researchers fed mice polystyrene microplastics of two sizes and tracked where the particles accumulated in the body, finding them in the liver, kidneys, and gut with distribution patterns depending on particle size. Biochemical analysis revealed that microplastic exposure disrupted energy and fat metabolism, caused oxidative stress, and altered markers of neurotoxicity in the blood. The study provides evidence that microplastics can accumulate in mammalian tissues and may pose widespread health risks.
Evaluation of Hematotoxicity in Female Wistar Rats Following Sub-Acute Inhalation Exposure to Polyethylene Microplastic
Female Wistar rats were exposed to polyethylene microplastic aerosols at 15 mg per cubic meter for 4 hours daily over 28 days, and blood analysis revealed alterations in erythrocyte, leukocyte, and platelet counts. The findings suggest that sub-acute inhalation of polyethylene microplastics can cause hematotoxic effects.
Morphological features of the internal organs in mice after prolonged microplastics consumption
Researchers fed mice polystyrene microplastics at three dose levels for four weeks and found dose-dependent morphological changes restricted to the spleen and colon, including inflammatory infiltration and alterations in mucin-secreting goblet cells, while other organs showed no significant pathological changes.
Assessment of the Toxicity of Polystyrene Microplastic in the Colon and Liver of Adult NMRI Mice
Researchers orally administered polystyrene microplastics to adult male mice at four doses for four weeks and examined histological changes in the colon and liver. Both organs showed dose-dependent tissue damage including inflammation and oxidative stress markers, with the colon showing earlier onset injury due to direct contact with ingested particles.
Polystyrene micro-/nanoplastics induced hematopoietic damages via the crosstalk of gut microbiota, metabolites, and cytokines
Researchers exposed mice to polystyrene micro- and nanoplastics and found that the particles caused damage to the blood-forming system through disruption of gut bacteria, metabolic changes, and inflammatory signaling. Smaller nanoplastics caused more severe effects than larger microplastics, altering gut microbial communities and triggering systemic inflammation. The study reveals a previously unknown pathway by which ingested plastic particles may harm the body's ability to produce healthy blood cells.
Effect of Polystyrene Microplastics Exposure on Blood Parameters in Mice
Researchers exposed mice to polystyrene microplastics in drinking water over four weeks and found increased white blood cell counts, elevated liver enzymes indicating hepatic injury, and altered kidney function markers. The study suggests that subchronic oral microplastic exposure induces inflammatory responses and disrupts liver and kidney function, with no significant recovery observed after a two-week withdrawal period.
A Western-style diet shapes the gut and liver responses to low-dose, fit-for-purpose polystyrene nanoplastics in mice
A subchronic mouse study found that low-dose polystyrene nanoplastics designed to mimic real-world particle characteristics impaired gut and liver health in a non-monotonic, diet-dependent manner, with Western-style diet amplifying the effects.
Polystyrene nanoplastics potentiate the development of hepatic fibrosis in high fat diet fed mice
Researchers found that polystyrene nanoplastics worsened liver damage in mice fed a high-fat diet by increasing oxidative stress, inflammation, and the infiltration of immune cells in liver tissue. The nanoplastic exposure accelerated the progression from fatty liver to hepatic fibrosis in the diet-induced model. The study suggests that nanoplastic exposure may compound the health risks associated with metabolic conditions affecting the liver.
Exploring the Impacts of Polyethylene Microplastics on Rat Liver
Wistar rats exposed to polyethylene microplastics at 0.1–5 mg/kg for 4 weeks showed dose-dependent PE accumulation in liver tissue confirmed by fluorescence microscopy, with histopathological signs of liver injury despite no significant change in body weight.
Oral exposure to polyethylene microplastics induces inflammatory and metabolic changes and promotes fibrosis in mouse liver.
Mice fed polyethylene microplastics in their food for 6 to 9 weeks developed liver inflammation, metabolic disruption, oxidative stress, and increased cell growth in the liver. The microplastics also worsened liver scarring (fibrosis) when tested in mice with pre-existing liver damage. This is the first study to show that ingesting polyethylene, the most common type of plastic, can directly damage the mammalian liver and could worsen existing liver conditions.
Kidney and Liver Disorders Due to Microplastic Exposure: Chronic in Vivo Study in Male White Rats
Male white rats were chronically exposed to microplastics (particles 5 mm or smaller) to assess kidney and liver toxicity, with exposure resulting from environmental weathering and ultraviolet irradiation of plastic materials. The study found measurable histopathological and biochemical damage in both organs, confirming that long-term microplastic exposure causes organ-level injury in mammals.
Systemic effects of nanoplastics on multi-organ at the environmentally relevant dose: The insights in physiological, histological, and oxidative damages
Researchers gave mice nanoplastics at doses estimated to match real-world human exposure levels and found the particles crossed the intestinal barrier and accumulated in the liver and kidneys. Even at these low, environmentally relevant doses, the nanoplastics caused oxidative stress and tissue damage across multiple organs. The findings suggest that everyday nanoplastic exposure may pose broader health risks than previously assumed.
The Histopathological and Genetic Effects of Long-Term Treatment with High-Molecular-Weight Polyvinyl Chloride on Various Organs of Young Wistar Rats
Researchers fed young Wistar rats food containing 1% or 2% polyvinyl chloride for eight weeks, finding histopathological damage to the intestines, liver, kidney, and spleen, along with genetic effects including DNA fragmentation, demonstrating organ-level toxicity of chronic PVC microplastic ingestion.
Microplastic Exposure Impairs Weight Gain, Reproduction, Blood Glucose Levels, and Organ Health in Rats (Rattus norvegicus)
Rats orally exposed to microplastic solutions at 1–10% concentrations over 28 days showed dose-dependent impairment of weight gain, reproductive function, blood glucose regulation, and organ health compared to controls—providing mammalian in vivo evidence that microplastic ingestion causes systemic physiological harm.
Pengaruh Mikroplastik Polyethylene Terephthalate (PET) Terhadap Profil Eritrosit Tikus Betina Galur Wistar
This animal study tested how PET microplastics (common in plastic bottles) affect blood cells in rats. Results showed that exposure to PET microplastics may lower red blood cell counts, hemoglobin, and hematocrit levels, suggesting potential effects on blood health that warrant further investigation in humans.
The Effect of Peroral Polyvinyl Chloride Microplastic on the Value of Prothrombin Time and Activated Partial Thromboplastin Time in Rattus Norvegicus Wistar Strain
Researchers found that Wistar rats given 0.5 mg/day of PVC microplastics orally exhibited altered prothrombin time and activated partial thromboplastin time values compared to controls, suggesting that microplastic accumulation in the liver impairs hepatocyte synthesis of blood clotting factors.
Microplastics cross the murine intestine and induce inflammatory cell death after phagocytosis by human monocytes and neutrophils
Researchers administered polystyrene microplastics orally to mice and then assessed distribution and immune cell interactions in both mice and human cells. Both 1 µm and 10 µm particles crossed the intestinal epithelium and were detected in blood and liver after 10 days, and human monocytes and neutrophils that ingested the particles underwent inflammatory cell death.