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A Western-style diet shapes the gut and liver responses to low-dose, fit-for-purpose polystyrene nanoplastics in mice

Environmental Science Nano 2025
Chloé Liebgott, Megan L. Mobley, Sophie Miguel, Valérie Bézirard, Catherine Beaufrand, Javier Jiménez‐Lamana, Rémi Dages, Marie Tramblay-Franco, Roselyne Gautier, Jordan Denis, Renaud Léonard, Grégory Da Costa, Catherine Robbe‐Masselot, Mathias L. Richard, Cécile Canlet, Bruno Grassl, Stéphanie Reynaud, Hervé Robert, Hélène Eutamène, Muriel Mercier‐Bonin

Summary

A subchronic mouse study found that low-dose polystyrene nanoplastics designed to mimic real-world particle characteristics impaired gut and liver health in a non-monotonic, diet-dependent manner, with Western-style diet amplifying the effects.

Polymers
Body Systems
Models

Subchronic exposure to fit-for-purpose polystyrene nanoplastics impairs gut and liver health at low doses with non-monotonic effects in a diet-dependent manner.

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