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61,005 resultsShowing papers similar to Intrinsic interaction inferred oxidative stress and apoptosis by Biosurfactant-microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish (Danio rerio)
ClearPolyethylene microplastic exposure and concurrent effect with Aeromonas hydrophila infection on zebrafish
Researchers found that polyethylene microplastic exposure in zebrafish caused oxidative stress, altered antioxidant enzyme activity, and induced intestinal damage, with concurrent Aeromonas hydrophila infection amplifying these toxic effects and increasing mortality rates.
Toxicological effects of microplastics and phenanthrene to zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene microplastics, the pollutant phenanthrene, and a combination of both to assess their toxicity over 24 days. They found that co-exposure amplified oxidative stress, suppressed immune gene expression, and significantly disrupted the gut microbiome compared to either contaminant alone. The study suggests that microplastics can worsen the toxic effects of organic pollutants in aquatic organisms by altering how chemicals accumulate and interact in the body.
Toxicity evaluation of the combination of emerging pollutants with polyethylene microplastics in zebrafish: Perspective study of genotoxicity, mutagenicity, and redox unbalance
Researchers exposed adult zebrafish to polyethylene microplastics combined with a mixture of common water pollutants for 15 days and assessed DNA damage, mutation rates, and oxidative stress. They found that microplastics alone caused DNA damage and nuclear abnormalities as severe as those caused by the pollutant mixture, challenging the assumption that microplastics are less harmful than chemical contaminants. The study revealed that the fish's antioxidant defenses were overwhelmed across multiple organs, suggesting widespread oxidative damage from microplastic exposure.
Combined toxic effects of polystyrene microplastics and 3,6-dibromocarbazole on zebrafish (Danio rerio) embryos
Researchers exposed zebrafish embryos to polystyrene microplastics along with a brominated pollutant (3,6-dibromocarbazole) and found that the combination produced unexpected results. While each pollutant individually caused oxidative stress and cell death, together they actually reduced these effects -- an antagonistic interaction. However, the microplastics acted as carriers that increased the accumulation of the toxic chemical in the fish, potentially amplifying its longer-term dioxin-like toxicity.
Eco-corona enhanced the interactive effects of nanoplastics and 6:2 chlorinated polyfluorinated ether sulfonate in zebrafish embryos
Researchers investigated how a natural coating called an eco-corona, formed from organic molecules in the environment, changes the way nanoplastics interact with a chemical pollutant in zebrafish embryos. They found that the eco-corona enhanced the combined toxic effects of nanoplastics and the co-occurring pollutant, leading to greater developmental harm. The study suggests that the real-world toxicity of nanoplastics may be worse than laboratory tests with clean particles indicate.
Influence of microplastics on bisphenol A and bisphenol AF toxicity in aquatic environments: Mechanistic insights for environmental risks
Researchers investigated how polyethylene microplastics interact with the industrial chemicals bisphenol A and bisphenol AF in zebrafish, finding that microplastics can either reduce or worsen the toxicity depending on the specific chemical and biological pathway involved. For bisphenol A, the microplastics partially absorbed the chemical and reduced its harmful effects, but for bisphenol AF, they worsened toxicity to certain organ systems. The study reveals that microplastics play a complicated dual role in modifying how other pollutants affect aquatic life.
Microplastic Interference with Fipronil Toxicity to Zebrafish Embryonic Development
Researchers studied how polyethylene microplastics affect the toxicity of the insecticide fipronil on developing zebrafish embryos. They found that while microplastics reduced the lethal effects of fipronil, likely by adsorbing some of the chemical, they did not change the rate of developmental abnormalities. The study highlights the complex ways different pollutants can interact in aquatic environments.
Combined toxicity of polyethylene micro/nanoplastics and PFOA in zebrafish (Danio rerio): Impacts on antioxidant, neurotransmission, and gut microbiota
Researchers exposed zebrafish to polyethylene micro/nanoplastics and the industrial pollutant PFOA individually and in combination, assessing antioxidant capacity, neurotransmission, and gut microbiome composition. Combined exposure caused greater oxidative stress, more severe neurotransmitter disruption, and larger gut microbiome shifts than either contaminant alone, highlighting synergistic risks of co-occurring plastic and PFAS pollution.
The Role of Synthetic Polymers in the Aquatic Environment and Its Implications in Danio Rerio as a Model Organism
Exposing zebrafish to polystyrene microplastics combined with silver nanoparticles caused significantly more oxidative damage, tissue injury in gills and intestines, and higher mortality than either contaminant alone. The study demonstrates that microplastics can act as carriers that enhance the toxicity of co-pollutants like silver nanoparticles, a combination effect that is highly relevant to understanding real-world aquatic contamination where multiple pollutants co-occur.
Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment
This review examines how nano- and micro-sized plastic particles cause toxic effects in zebrafish, focusing on the link between oxidative stress and neurodevelopmental damage. Researchers found that plastic particle exposure disrupts the balance of reactive oxygen species in cells, which can impair brain development and nervous system function. The study suggests these oxidative stress responses may serve as early warning signals of plastic particle toxicity in aquatic organisms.
The influence of different polymer types of microplastics on adsorption, accumulation, and toxicity of triclosan in zebrafish
Researchers investigated how different polymer types of microplastics affect the toxicity and bioaccumulation of the antimicrobial chemical triclosan in zebrafish. They found that polypropylene microplastics had the highest capacity to adsorb triclosan and that co-exposure significantly worsened oxidative stress, lipid damage, and neurotoxicity compared to triclosan alone. The study demonstrates that the type of microplastic polymer matters when assessing the combined environmental risks of plastics and chemical pollutants.
Genotoxic and Oxidative Damage of Environmental Pollutant Microplastics on Zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene and polyethylene microplastics at different concentrations for up to 21 days to measure oxidative stress and DNA damage. The study found that both types of microplastics disrupted the antioxidant system and caused measurable DNA damage, with effects depending on dosage and exposure time. These results suggest that microplastics in waterways could pose genetic and cellular risks to aquatic life.
Immunotoxicological effects of perfluorooctanesulfonic acid on European seabass are reduced by polyethylene microplastics
Researchers fed European seabass diets containing the industrial chemical PFOS, polyethylene microplastics, or both combined, and measured immune system effects. Surprisingly, they found that when PFOS was adsorbed onto microplastics, its toxic effects on the fish immune system were actually reduced compared to PFOS exposure alone. The study suggests that microplastics may sometimes limit the bioavailability of certain chemical pollutants, though the overall environmental implications remain complex.
Combined effects of microplastics and chemical contaminants on the organ toxicity of zebrafish ( Danio rerio )
Researchers studied the combined effects of microplastics and chemical contaminants like PCBs and methylmercury on zebrafish organs over three weeks of exposure. They found that microplastics carrying adsorbed contaminants produced the most significant effects, particularly on the liver, compared to either microplastics or contaminants alone. The results indicate that microplastics may act as carriers that increase the delivery of harmful chemicals to organisms' tissues.
Combined effects of polyethylene and organic contaminant on zebrafish (Danio rerio): Accumulation of 9-Nitroanthracene, biomarkers and intestinal microbiota
Researchers studied how polyethylene microplastics interact with the pollutant 9-Nitroanthracene in zebrafish, both individually and in combination. The study found that while microplastics can carry the pollutant into the fish, they actually reduced its accumulation by adsorbing it away from biological tissues. However, long-term combined exposure proved more toxic than either pollutant alone, suggesting delayed harmful effects when microplastics and chemical contaminants coexist in waterways.
Synergetic effects of polyethylene microplastic and abamectin pesticides on the eyes of zebrafish larvae and adults through activation of apoptosis signaling pathways
Researchers exposed zebrafish to polyethylene microplastics and the pesticide abamectin, both individually and in combination, and found that the mixture caused significantly worse eye damage and lower survival rates than either pollutant alone. The combined exposure triggered higher levels of oxidative stress and activated cell death pathways in eye tissues. The study reveals that microplastics and pesticides can interact to produce amplified toxic effects on aquatic organisms, particularly affecting their vision.
Structure activity toxicity of different micro-nanoplastics on developing Zebrafish (Danio rerio) based on individual polymer chemistry
This dissertation examined the toxicity of individual polymer chemistries—rather than generic microplastic mixtures—on zebrafish embryos and larvae, finding polymer-specific differences in developmental toxicity, behavioral disruption, and biochemical pathway activation across multiple plastic types.
Influence of microplastic-associated biofilms on the bioavailability of a mixture of cadmium and benzo[a]pyrene by the analysis of biomarker gene expression in larval zebrafish
Researchers found that microbial biofilms — thin layers of bacteria that coat microplastics in water — selectively reduce how much of a toxic chemical called benzo[a]pyrene gets absorbed by larval zebrafish, while not affecting cadmium absorption, showing that microplastics can act as complex, biology-influenced carriers of multiple pollutants simultaneously.
Polystyrene microplastics decrease F–53B bioaccumulation but induce inflammatory stress in larval zebrafish
Researchers exposed zebrafish larvae to polystyrene microplastics, the industrial chemical F-53B, or both in combination over seven days. The study found that while microplastics decreased the bioaccumulation of F-53B in the larvae, the combined exposure induced significant inflammatory stress responses, suggesting that microplastics can alter how other contaminants interact with aquatic organisms.
Effects of microplastics on the toxicity of co-existing pollutants to fish: A meta-analysis
Meta-analysis of 1,380 biological endpoints from 55 studies found that microplastics in co-existing pollutant solutions significantly increased toxicity to fish beyond what the pollutants caused alone, particularly elevating immune system damage, metabolic disruption, and oxidative stress. The effect depended on fish life stage and microplastic size, but not on pollutant or polymer type.
Evaluation of protective efficacy of quercetin on microplastic induced behavioural toxicity in zebrafish (Danio rerio)
Zebrafish were exposed to microplastics alone and in combination with quercetin at 75 ug/L for 21 days to evaluate whether quercetin could protect against microplastic-induced behavioral toxicity. Microplastic exposure caused behavioral abnormalities, and quercetin treatment modified these effects in a dose-dependent manner, suggesting antioxidant supplementation as a potential protective strategy.
Quantitative investigation of the mechanisms of microplastics and nanoplastics toward zebrafish larvae locomotor activity
Researchers investigated how microplastics and nanoplastics affect zebrafish larvae swimming behavior through both direct toxicity and interactions with the hormone-disrupting chemical EE2. They found that nanoplastics alone inhibited locomotion by causing oxidative damage and reducing body length, while microplastics had minimal direct effects. When combined with chemical pollutants, both plastic sizes altered toxicity outcomes, suggesting that the real-world impact of plastic particles depends heavily on what other contaminants are present.
Microplastics reduce the bioaccumulation and oxidative stress damage of triazole fungicides in fish
Researchers found that microplastics can reduce the bioaccumulation and oxidative stress damage of triazole fungicides in fish, suggesting that microplastic-pesticide interactions may alter the expected toxicity of agricultural chemicals in aquatic organisms.
Ecotoxicological evaluation of chitosan biopolymer films particles in adult zebrafish (Danio rerio): A comparative study with polystyrene microplastics
Researchers compared the effects of chitosan biopolymer film particles, a proposed eco-friendly alternative to plastic, against conventional polystyrene microplastics in adult zebrafish. They found that while both materials caused oxidative stress, the biopolymer tended to activate protective antioxidant responses, whereas polystyrene triggered more damaging effects including cell death pathways. The study suggests that biodegradable alternatives to plastic may still affect aquatic organisms, though potentially in less harmful ways than traditional microplastics.