Effects of microplastics on the toxicity of co-existing pollutants to fish: A meta-analysis

Aquatic ecosystems are among the main destination for microplastics (MPs) in the environment. MPs that enter aquatic ecosystems can contribute to pollution together with other co-existing pollutants. However, whether such pollution results in higher or lower toxicity to fish than that caused by co-existing pollutants alone remains controversial. This study aimed at closing this research gap based on 1380 biological endpoints under the background of environmental MP concentrations collected from 55 laboratory studies. Overall, MPs in co-existing pollutant solutions significantly increased the toxicity to fish. Specifically, MPs elevated negative effects on the immune system, metabolism, and oxidative damage. Subgroup analysis indicated that changes in toxicity were related to fish life stage and MP size, but not to co-existing pollutant or MP type. Meta-regression analysis indicated that changes in toxicity were not related to the logarithm of the octanol-water partition coefficient (logKow) or exposure time. Finally, the differences between laboratory research and the actual aquatic environment were discussed from four aspects: MPs, co-existing pollutants, environmental factors, and experimental objects. Our study provides a basis for further understanding the potential impact of MPs on aquatic organisms from a combined pollution perspective. Moreover, our results can provide a reference for the conservation and management of aquatic ecosystems.