Back to papers
0
Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Marine & Wildlife Sign in to save

Synergetic effects of polyethylene microplastic and abamectin pesticides on the eyes of zebrafish larvae and adults through activation of apoptosis signaling pathways

Environmental Toxicology and Pharmacology 2023 25 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Ajay Guru, Ajay Guru, Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Noura Darwish, Noura Darwish, Ahmed Rady, Ahmed Rady, Ajay Guru, Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Noura Darwish, Noura Darwish, Noura Darwish, Noura Darwish, Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Selvaraj Arokiyaraj, Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Ajay Guru, Selvaraj Arokiyaraj, Selvaraj Arokiyaraj, Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Jesu Arockiaraj, Jesu Arockiaraj, Jesu Arockiaraj, Guilherme Malafaia Jesu Arockiaraj, Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Jesu Arockiaraj, Selvaraj Arokiyaraj, Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Selvaraj Arokiyaraj, Guilherme Malafaia Guilherme Malafaia Selvaraj Arokiyaraj, Selvaraj Arokiyaraj, Guilherme Malafaia Guilherme Malafaia Selvaraj Arokiyaraj, Guilherme Malafaia Selvaraj Arokiyaraj, Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Ajay Guru, Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Ajay Guru, Ajay Guru, Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Jesu Arockiaraj, Jesu Arockiaraj, Jesu Arockiaraj, Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia Guilherme Malafaia

Summary

Researchers exposed zebrafish to polyethylene microplastics and the pesticide abamectin, both individually and in combination, and found that the mixture caused significantly worse eye damage and lower survival rates than either pollutant alone. The combined exposure triggered higher levels of oxidative stress and activated cell death pathways in eye tissues. The study reveals that microplastics and pesticides can interact to produce amplified toxic effects on aquatic organisms, particularly affecting their vision.

Polymers
PE
Models
Zebrafish

Although the toxicity of microplastics (MPs) and pesticides has recently been described, the possible effects of combining these pollutants are poorly understood. Thus, we evaluated the potential impact of exposure to polyethylene MP (PE-MP) and abamectin (ABM) (alone and combined) in zebrafish. After five days, the combined exposure to MP and ABM decreased the survival rate compared to exposures to individual pollutants. A significant increase in reactive oxygen species (ROS), lipid peroxidation, apoptosis, and impairment in antioxidant response was observed in zebrafish larvae. Morphological changes in the eyes of zebrafish significantly increased in the combined exposure group than in the individual exposure. Furthermore, the bax and p53 expression (specific apoptotic genes) was significantly upregulated after the combined exposure to PE-MP and ABM. So, the synergetic effect of MP and ABM cannot be ignored, and further research on other higher models is required to confirm its consequences.

Read via DOI PubMed

Sign in to start a discussion.

Share this paper

Post Share Share Pin Email