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61,005 resultsShowing papers similar to Tempol Attenuates Methotrexate-Induced Osteotoxicity via Antioxidant Mechanisms: Impairment of Protection by GPX4 Inhibition Through ML210
ClearQuercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells
Researchers found that quercetin, a natural plant compound, protected mouse ovaries from chemotherapy-induced damage by reducing harmful oxidative stress in mitochondria and suppressing a form of inflammatory cell death called pyroptosis, suggesting it could help preserve fertility in patients undergoing cancer treatment.
Human Mesenchymal Stem Cells-Derived Exosome Mimetic Vesicles Regulation of the MAPK Pathway and ROS Levels Inhibits Glucocorticoid-Induced Apoptosis in Osteoblasts
Researchers found that exosome-mimetic vesicles derived from human mesenchymal stem cells can help protect bone-forming cells from glucocorticoid-induced programmed cell death. The study suggests these vesicles work by regulating the MAPK signaling pathway and reducing reactive oxygen species levels in laboratory experiments.
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells
Researchers found that oridonin, a natural plant compound, can trigger two different types of cell death simultaneously in bone cancer cells. This dual mechanism makes it effective at suppressing tumor growth in osteosarcoma. The study suggests oridonin could be a promising therapeutic agent for treating this type of bone cancer.
Modulation efficiency of clove oil nano-emulsion against genotoxic, oxidative stress, and histological injuries induced via titanium dioxide nanoparticles in mice
Researchers found that titanium dioxide nanoparticles (used widely in sunscreens and food products) caused DNA damage, oxidative stress, and organ tissue injury in mice, but that a clove oil nanoemulsion significantly reversed these harmful effects — suggesting a natural antioxidant treatment may protect against nanoparticle toxicity.
Exogenous Hydrogen Sulfide Mitigates Oxidative Stress and Mitochondrial Damages Induced by Polystyrene Microplastics in Osteoblastic Cells of Mice
Researchers found that polystyrene microplastics induced oxidative stress, mitochondrial damage, and altered gene expression in mouse bone-forming cells, while exogenous hydrogen sulfide treatment mitigated these toxic effects by modulating key signaling pathways.
Apigetrin ameliorates doxorubicin prompted testicular damage: biochemical, spermatological and histological based study
Researchers tested whether the flavonoid apigetrin could protect rat testicular tissue from damage caused by the chemotherapy drug doxorubicin. They found that doxorubicin caused significant oxidative stress, inflammation, hormone imbalance, and tissue damage in the testes, but co-administration of apigetrin substantially reduced these harmful effects. The study suggests that natural plant compounds may help protect reproductive health during cancer treatment.
Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
This study reviewed how nanoplastic particles disrupt the bone microenvironment through oxidative stress and damage to the extracellular matrix. Reactive oxygen species generated by nanoplastic exposure were found to drive toxicity in bone cells.
Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
Researchers reviewed how nanoplastics affect the bone microenvironment, focusing on oxidative stress pathways and extracellular matrix disruption as key mechanisms of toxicity. Reactive oxygen species generated by nanoplastic exposure were identified as drivers of bone cell damage.
Polystyrene microplastics disrupt osteogenic differentiation via lysosome-mediated mitochondrial dysfunction: Protective role of mTOR signaling
Researchers identified a mechanistic pathway by which polystyrene microplastics impair bone formation in zebrafish and mouse preosteoblasts: PS-MPs accumulate in lysosomes, trigger mitochondrial dysfunction, and suppress osteogenic differentiation. Activation of the mTOR signaling pathway was found to partially protect against this bone toxicity.
Glutathione's antioxidant effects and its ability to shield mice's hepatocytes from damage caused by furan
Researchers investigated the protective effects of glutathione supplementation against furan-induced liver and kidney damage in mice. They found that furan exposure significantly increased markers of organ damage and oxidative stress, while glutathione supplementation helped mitigate these harmful effects. The study suggests that antioxidant supplementation may offer some degree of protection against the toxic effects of furan, a contaminant commonly found in heat-treated foods.
Epigallocatechin-gallate ameliorates polystyrene microplastics-induced oxido-inflammation and mitochondria-mediated apoptosis in testicular cells via modulation of Nrf2/HO-1, /mTOR/Atg-7, and Cx-43/NOX-1 levels
Researchers found that polystyrene microplastics caused oxidative stress, inflammation, and reduced sperm quality in rats, but that treatment with EGCG — a compound found in green tea — reversed most of these harmful effects by restoring antioxidant defenses and reducing cell death pathways in testicular tissue.
Resveratrol attenuated high intensity exercise training-induced inflammation and ferroptosis via Nrf2/FTH1/GPX4 pathway in intestine of mice
Researchers found that resveratrol attenuated inflammation and ferroptosis caused by high-intensity exercise training in the intestines of mice. The protective effect was mediated through activation of the Nrf2/FTH1/GPX4 pathway in colon tissue, suggesting potential applications for preventing exercise-induced gut damage.
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cell
This study investigated the anti-tumor effects of oridonin, a natural plant compound, on osteosarcoma cells, finding it triggered both ferroptosis and apoptosis to suppress tumor growth. While focused on cancer treatment rather than microplastics, the ferroptosis pathway studied is also implicated in cellular damage caused by microplastic exposure.
Nanoplastic-Induced Liver Damage Was Alleviated by Maltol via Enhancing Autophagic Flow: An In Vivo and In Vitro Study
Researchers found that nanoplastic exposure caused liver damage in mice through oxidative stress, cell death, and impaired cellular recycling processes. They then tested maltol, a compound derived from red ginseng, and found it significantly reduced the liver damage by restoring healthy autophagy and reducing oxidative stress. The study suggests that natural compounds like maltol could potentially help protect the liver from the harmful effects of nanoplastic accumulation.
CTLA4-Ig protects tacrolimus-induced oxidative stress via inhibiting the AKT/FOXO3 signaling pathway in rats
Researchers found that CTLA4-Ig exerts a direct protective effect against tacrolimus-induced renal oxidative stress in rats by inhibiting the AKT/FOXO3 signaling pathway, identifying a mechanism by which this immunosuppressive agent may reduce nephrotoxicity associated with tacrolimus treatment.
ALDH2 Ameliorates Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and Pyroptosis by Nrf2/ROS Pathway
Researchers found that activation of the ALDH2 enzyme via Alda-1 alleviates monosodium urate (MSU)-induced oxidative stress and inflammation in acute gouty arthritis by regulating the Nrf2/ROS pathway and inhibiting NLRP3 inflammasome activation and pyroptosis. The findings suggest ALDH2 activation represents a promising therapeutic strategy for managing acute gouty arthritis.
Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells
This study found that nanoplastics are toxic to bone cells in mice, causing cell death, increased production of damaging reactive oxygen species, and disruption of the bone remodeling process. The nanoplastics impaired the ability of bone-building cells to migrate and promoted the formation of bone-destroying cells. These findings suggest that nanoplastic exposure could potentially contribute to bone diseases like osteoporosis, though more research in living animals and humans is needed.
Alpha‐Mangostin Alleviates Mitochondrial Damage and Autophagy Dysregulation in the MPP + Cellular Model of Parkinson’s Disease
Researchers found that alpha-mangostin pretreatment protected neuronal cells from mitochondrial damage in a cellular model of Parkinson's disease, working through the mTOR autophagy pathway to reduce oxidative stress and improve mitochondrial integrity under conditions mimicking MPP⁺ toxicity.
Allantoin Derived From Dioscorea opposita Thunb Ameliorates Cyclophosphamide-Induced Premature Ovarian Failure in Female Rats by Attenuating Apoptosis, Autophagy and Pyroptosis
Researchers studied whether allantoin, a compound from a Chinese yam species, could protect female rats from ovarian damage caused by the chemotherapy drug cyclophosphamide. They found that allantoin treatment reduced ovarian cell death through multiple protective pathways and helped preserve ovarian function. While this study does not involve microplastics, it contributes to understanding how natural compounds may help protect reproductive health from toxic chemical exposures.
Effects of Polystyrene Microplastics on Bone-related Protein Expression, Mineralization Capacity, and Mitochondrial Function in Osteoblast-like Cells (mg-63)
Osteoblast-like cells (MG-63) were exposed to polystyrene microplastics at 5–50 µg/mL, and bone-related protein expression, mineralisation capacity, and mitochondrial function were assessed. PS-MPs were internalised and reduced mineralisation and osteocalcin levels while impairing mitochondrial bioenergetics, suggesting microplastics may negatively affect bone cell function.
Pneumotoxicity of Styrene Oxide and the Possible Protective Role of Thymosin β4 in Albino Rat: Biochemical and Immunohistochemical Study
Researchers found that styrene oxide — a metabolite of the plastic-related compound styrene — caused significant lung tissue damage, inflammation, and oxidative stress in rats, while co-administration of thymosin β4 protein substantially reduced these toxic effects.
Pharmacodynamic Material Basis and Potential Mechanism Study of Spatholobi Caulis in Reversing Osteoporosis
Researchers investigated the pharmacological mechanisms of Spatholobi Caulis (SC) in reversing osteoporosis, finding it operates through multi-component, multi-target pathways with the AGE-RAGE signaling pathway identified as the primary regulatory mechanism.
Attenuative Effects of Ginkgetin Against Polystyrene Microplastics-Induced Renal Toxicity in Rats
Researchers found that ginkgetin, a natural flavonoid, significantly reduced polystyrene microplastic-induced kidney damage in rats by restoring antioxidant enzyme activity and reducing oxidative stress and inflammation markers.
Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight
This review examines the anticancer mechanisms of polydatin, a natural stilbenoid compound, detailing its ability to inhibit tumor growth through antioxidant, anti-inflammatory, and apoptotic pathways across multiple cancer types.