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CTLA4-Ig protects tacrolimus-induced oxidative stress via inhibiting the AKT/FOXO3 signaling pathway in rats
Summary
Researchers found that CTLA4-Ig exerts a direct protective effect against tacrolimus-induced renal oxidative stress in rats by inhibiting the AKT/FOXO3 signaling pathway, identifying a mechanism by which this immunosuppressive agent may reduce nephrotoxicity associated with tacrolimus treatment.
CTLA4-Ig has a direct protective effect on TAC-induced renal injury via the inhibition of AKT/FOXO3 pathway.
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