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Nanoplastics
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Nanoplastic impact on bone microenvironment: A snapshot from murine bone cells
Journal of Hazardous Materials2023
36 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 60
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Michela Sugni
Domenica Giannandrea,
Domenica Giannandrea,
Domenica Giannandrea,
Domenica Giannandrea,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Beatrice De Felice,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Michela Sugni
Martina Chiu,
Alessandro Villa,
Alessandro Villa,
Beatrice De Felice,
Beatrice De Felice,
Marco Parolini,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Marco Parolini,
Marco Parolini,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Valentina Citro,
Beatrice De Felice,
Valentina Citro,
Beatrice De Felice,
Marco Parolini,
Lavinia Casati,
Beatrice De Felice,
Beatrice De Felice,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Michela Sugni
Marco Parolini,
Beatrice De Felice,
Marco Parolini,
Beatrice De Felice,
Marco Parolini,
Marco Parolini,
Michela Sugni
Michela Sugni
Beatrice De Felice,
Beatrice De Felice,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Beatrice De Felice,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Raffaella Chiaramonte,
Lavinia Casati,
Lavinia Casati,
Lavinia Casati,
Beatrice De Felice,
Valentina Citro,
Valentina Citro,
Alex Pezzotta,
Alex Pezzotta,
Michela Sugni
Michela Sugni
Michela Sugni
Raffaella Chiaramonte,
Marco Parolini,
Nazanin Abazari,
Marco Parolini,
Nazanin Abazari,
Nazanin Abazari,
Natalia Platonova,
Natalia Platonova,
Marco Parolini,
Marco Parolini,
Beatrice De Felice,
Marco Parolini,
Nazanin Abazari,
Michela Sugni
Marco Parolini,
Natalia Platonova,
Beatrice De Felice,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Natalia Platonova,
Natalia Platonova,
Elena Lesma,
Natalia Platonova,
Elena Lesma,
Marco Parolini,
Michela Sugni
Marco Parolini,
Michela Sugni
Marco Parolini,
Raffaella Chiaramonte,
Michela Sugni
Raffaella Chiaramonte,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Martina Chiu,
Martina Chiu,
Marco Parolini,
Marco Parolini,
Alessandro Villa,
Beatrice De Felice,
Beatrice De Felice,
Beatrice De Felice,
Alessandro Villa,
Marco Parolini,
Elena Lesma,
Elena Lesma,
Marco Parolini,
Marco Parolini,
Raffaella Chiaramonte,
Raffaella Chiaramonte,
Lavinia Casati,
Lavinia Casati,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Marco Parolini,
Michela Sugni
Summary
This study found that nanoplastics are toxic to bone cells in mice, causing cell death, increased production of damaging reactive oxygen species, and disruption of the bone remodeling process. The nanoplastics impaired the ability of bone-building cells to migrate and promoted the formation of bone-destroying cells. These findings suggest that nanoplastic exposure could potentially contribute to bone diseases like osteoporosis, though more research in living animals and humans is needed.
Our world is made of plastic. Plastic waste deeply affects our health entering the food chain. The degradation and/or fragmentation of plastics due to weathering processes result in the generation of nanoplastics (NPs). Only a few studies tested NPs effects on human health. NPs toxic actions are, in part, mediated by oxidative stress (OS) that, among its effects, affects bone remodeling. This study aimed to assess if NPs influence skeleton remodeling through OS. Murine bone cell cultures (MC3T3-E1 preosteoblasts, MLOY-4 osteocyte-like cells, and RAW264.7 pre-osteoclasts) were used to test the NPs detrimental effects on bone cells. NPs affect cell viability and induce ROS production and apoptosis (by caspase 3/7 activation) in pre-osteoblasts, osteocytes, and pre-osteoclasts. NPs impair the migration capability of pre-osteoblasts and potentiate the osteoclastogenesis of preosteoclasts. NPs affected the expression of genes related to inflammatory and osteoblastogenic pathways in pre-osteoblasts and osteocytes, related to the osteoclastogenic commitment of pre-osteoclasts. A better understanding of the impact of NPs on bone cell activities resulting in vivo in impaired bone turnover could give more information on the possible toxicity consequence of NPs on bone mass and the subsequent public health problems, such as bone disease.