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61,005 resultsShowing papers similar to Protective effects of exocarpium citri grandis extract and its flavonoid components against polystyrene microplastic-induced hepatointestinal injury
ClearNarirutin ameliorates polystyrene microplastics induced nephrotoxicity by modulating oxidative stress, inflammation and Nrf2/Keap1 pathway
Researchers investigated whether narirutin, a natural compound found in citrus fruits, could protect kidneys from damage caused by polystyrene microplastics in rats. The study suggests that microplastic exposure triggered significant kidney stress through oxidation and inflammation, but narirutin helped reduce that damage by activating protective cellular pathways.
Oxidative and Inflammatory Damage by Environmental Polyethylene Microplastics in Caco‐2 Cells Is Prevented by Polyphenol‐Rich Limoncella Apple Extract
Lab experiments on human gut cells (Caco-2) found that polyethylene microplastics increase oxidative stress and trigger cellular changes associated with disease progression, but that an extract from Limoncella apples rich in polyphenols could counteract these harmful effects. This raises the possibility that dietary antioxidants could offer a protective strategy against microplastic-induced damage in the human digestive system.
Quercetin intervention mitigates small intestinal damage and immunologic derangement induced by polystyrene nanoplastics: Insights from multi-omics analysis in mice
Researchers found that quercetin, a natural compound found in fruits and vegetables, protected mice from gut damage and immune system disruption caused by polystyrene nanoplastics. The nanoplastics damaged the small intestine and disrupted immune balance, but quercetin reversed much of this harm by restoring healthy gut bacteria and gene activity. This suggests that dietary compounds like quercetin might help counteract some negative health effects of nanoplastic exposure.
Attenuative effects of poncirin against polyethylene microplastics-prompted hepatotoxicity in rats
Researchers tested whether poncirin, a natural plant compound, could protect rat livers from damage caused by polyethylene microplastics. They found that microplastic exposure caused significant oxidative stress, inflammation, and liver tissue damage, which poncirin was able to substantially reduce by activating protective antioxidant pathways. The study suggests that natural compounds like poncirin may help counteract some of the harmful effects of microplastic exposure on the liver.
Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota
This study found that rosmarinic acid, a natural plant compound, protected mice from intestinal inflammation by restoring healthy gut bacteria and reducing cell stress and damage. While not directly about microplastics, the research is relevant because microplastics are known to cause similar gut inflammation and disrupt the gut microbiome. Understanding how natural compounds can repair gut damage may help develop strategies to counteract the harmful effects of microplastic exposure on digestive health.
Gut Microbiota Participates in Polystyrene Microplastics-Induced Hepatic Injuries by Modulating the Gut–Liver Axis
This mouse study showed that polystyrene microplastics cause liver damage partly through disrupting gut bacteria, which then triggers harmful signals along the gut-liver connection. When researchers eliminated gut bacteria with antibiotics, liver damage from microplastics was reduced, confirming the gut microbiome plays a key role. Green tea extract (EGCG) helped protect the liver by restoring healthy gut bacteria, suggesting diet may help counteract some effects of microplastic exposure.
Protective effects of herbacetin against polystyrene microplastics-instigated liver damage in rats
Researchers investigated the protective effects of herbacetin, a natural flavonoid, against liver damage caused by polystyrene microplastic exposure in rats. The study found that herbacetin helped restore antioxidant enzyme levels and reduce inflammation markers, suggesting it may offer some protection against microplastic-associated oxidative stress in liver tissue.
Effect of Pineapple Extract on Superoxide Rat Microplastic-induced Liver Injury Model
Scientists fed rats tiny plastic particles (microplastics) to damage their livers, then gave some rats pineapple extract to see if it would help protect them. The pineapple extract boosted levels of an important protective enzyme that fights damage from microplastics. This early research suggests that eating pineapple might help our bodies defend against the harmful effects of microplastics we consume from food and water, though more studies are needed to confirm this works in humans.
Nobiletin‐mediated autophagy mitigates nanoplastic‐induced toxicity in human intestinal Caco‐2 cells
Researchers found that nobiletin, a natural compound from citrus peel, can protect human intestinal cells from damage caused by nanoplastics. The compound worked by activating autophagy, a cellular cleanup process that helps cells remove harmful materials. The study suggests that certain plant-derived compounds may offer a protective effect against the intestinal damage associated with nanoplastic exposure.
Didymin protects against polystyrene nanoplastic-induced hepatic damage in male albino rats by modulation of Nrf-2/Keap-1 pathway
Researchers tested whether didymin, a natural compound found in citrus fruits, could protect rat livers from damage caused by polystyrene nanoplastics. They found that didymin significantly reduced oxidative stress and inflammation by activating a key protective cellular pathway. The study suggests that certain dietary compounds may help counteract some of the harmful effects of nanoplastic exposure on the liver.
Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice
Researchers found that cyanidin-3-O-glucoside (C3G), a naturally occurring anthocyanin compound found in many fruits and vegetables, helped reduce the harmful effects of polystyrene microplastics in mice. C3G supplementation promoted the excretion of microplastics, reduced tissue accumulation, and alleviated oxidative stress and inflammation caused by the particles. The study also showed that C3G helped restore healthy gut microbiota that had been disrupted by microplastic exposure.
Investigating the protective effects of epigallocatechin-gallate against polystyrene microplastics-induced biochemical and hematological alterations in rats
This study investigated whether epigallocatechin-gallate (EGCG) -- a green tea antioxidant -- could protect rats from biochemical and hematological damage caused by polystyrene microplastic ingestion. EGCG supplementation partially mitigated oxidative stress and inflammatory markers elevated by polystyrene microplastic exposure, suggesting a potential dietary protective strategy.
Epigallocatechin-3-gallate ameliorates polystyrene microplastics-induced anxiety-like behavior in mice by modulating gut microbe homeostasis
A mouse study found that exposure to polystyrene microplastics caused anxiety-like behavior by disrupting gut bacteria and triggering brain inflammation. A green tea compound called EGCG (epigallocatechin-3-gallate) reversed these effects by restoring healthy gut microbe balance and reducing inflammation in the brain. This suggests the gut-brain connection plays a key role in how microplastics affect mental health, and that certain dietary compounds might offer protection.
Gut microbiota and liver metabolomics reveal the potential mechanism of Lactobacillus rhamnosus GG modulating the liver toxicity caused by polystyrene microplastics in mice
Researchers found that the probiotic Lactobacillus rhamnosus GG helped protect mice from liver damage caused by polystyrene microplastic exposure. The probiotic worked by restoring healthy gut bacteria and normalizing liver metabolic pathways disrupted by the microplastics. The study suggests that supporting gut health through beneficial bacteria may help mitigate some of the toxic effects microplastics have on the liver.
Effects of polystyrene microplastics on mice cardiac tissue structure: Protective role of resveratrol
Researchers exposed mice to polystyrene microplastics for 90 days and found that the particles caused significant oxidative stress and structural damage to heart tissue. However, when mice also received resveratrol, a natural antioxidant compound found in grapes and berries, much of the cardiac damage was prevented. The study suggests that antioxidant compounds may offer some protective benefit against microplastic-induced heart tissue damage.
The role of human intestinal mucus in the prevention of microplastic uptake and cell damage
Researchers studied how the mucus lining of the human intestine acts as a barrier against microplastic particles of different sizes and surface coatings. The mucus layer significantly reduced microplastic uptake by cells and protected against toxicity and inflammation. This study suggests that a healthy intestinal mucus layer is an important natural defense against the harmful effects of swallowed microplastics.
Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice
Researchers exposed mice to polystyrene microplastics for six weeks and found that the particles accumulated in the gut, reduced protective mucus secretion, and damaged the intestinal barrier. The microplastics also significantly altered the composition of gut bacteria, decreasing beneficial species and increasing harmful ones. The study suggests that microplastic ingestion could disrupt gut health in mammals by simultaneously impairing the physical barrier and reshaping the microbiome.
Protective Effect of Resveratrol on Kidney Disease and Hypertension Against Microplastics Exposure in Male Juvenile Rats
Researchers investigated whether resveratrol, a natural plant compound, could protect young rats from kidney damage and high blood pressure caused by microplastic exposure. They found that microplastics elevated blood pressure and creatinine levels through oxidative stress, and that resveratrol treatment effectively prevented these effects. The study suggests resveratrol may offer protective benefits against organ damage linked to microplastic exposure, partly by improving gut microbiota balance.
Protective effect of curcumin against microplastic and nanoplastics toxicity
Researchers reviewed studies examining whether curcumin, the active compound in turmeric, can protect against the toxic effects of micro- and nanoplastics in the body. Evidence indicates that curcumin helped reduce oxidative stress, inflammation, and organ damage caused by plastic particle exposure across multiple organ systems in animal studies. The review suggests that natural antioxidant compounds like curcumin may hold promise for mitigating some of the harmful effects of plastic pollution on health.
Anthocyanins as protectors of gut microbiota: mitigating the adverse effects of microplastic-induced disruption
This review examines how anthocyanins, bioactive compounds found in berries and other pigmented plants, may protect gut microbiota from disruption caused by microplastic exposure. Researchers synthesized evidence suggesting that anthocyanins counteract microplastic-induced oxidative stress and inflammation in the gut. The findings indicate that dietary anthocyanins could serve as a protective factor against the adverse effects of microplastics on digestive health.
Assessment of the cytotoxicity micro- and nano-plastic on human intestinal Caco-2 cells and the protective effects of catechin.
Researchers used a human intestinal cell line (Caco-2) to test cytotoxicity of polystyrene micro- and nano-plastics, finding dose-dependent cell damage and disruption of intestinal barrier function. The study supports growing concerns that ingested microplastics could contribute to gut inflammation and compromise the protective lining of the human intestine.
Lactic acid bacteria reduce polystyrene micro- and nanoplastics-induced toxicity through their bio-binding capacity and gut environment repair ability
Researchers found that lactic acid bacteria, the kind used in yogurt and fermented foods, can reduce the toxic effects of polystyrene micro and nanoplastics in mice. The bacteria worked by physically binding to the plastic particles and by repairing damage to the gut lining and restoring healthy gut bacteria populations. This suggests that probiotics could be a practical way to help protect the digestive system from the harmful effects of microplastic exposure through food and water.
Attenuative effects of tamarixetin against polystyrene microplastics‐induced hepatotoxicity in rats by regulation of Nrf‐2/Keap‐1 pathway
Researchers investigated whether tamarixetin, a naturally occurring flavonoid, could reduce liver damage caused by polystyrene microplastic exposure in rats. The study found that tamarixetin helped protect against microplastic-induced liver toxicity by activating antioxidant defense pathways, suggesting potential protective effects of certain plant-derived compounds against microplastic-related oxidative stress.
Attenuative Effects of Ginkgetin Against Polystyrene Microplastics-Induced Renal Toxicity in Rats
Researchers found that ginkgetin, a natural flavonoid, significantly reduced polystyrene microplastic-induced kidney damage in rats by restoring antioxidant enzyme activity and reducing oxidative stress and inflammation markers.