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Effects of polystyrene microplastics on mice cardiac tissue structure: Protective role of resveratrol
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Researchers exposed mice to polystyrene microplastics for 90 days and found that the particles caused significant oxidative stress and structural damage to heart tissue. However, when mice also received resveratrol, a natural antioxidant compound found in grapes and berries, much of the cardiac damage was prevented. The study suggests that antioxidant compounds may offer some protective benefit against microplastic-induced heart tissue damage.
Microplastics, as ubiquitous environmental particles, can influence cardiac function both directly and indirectly. We examined the beneficial effects of resveratrol on the cardiotoxicity induced by 2-μm polystyrene microplastics in murine models. Male NMRI mice (n = 27) Control, PS-MPs (1 mg/kg), and PS-MPs + RV (1 mg/kg PS-MPs+2.5 mg/kg RV) were randomly grouped into three. Histological and antioxidant parameters were assessed after 90 days of exposure. Our findings indicated that PS-MPs induce toxicity via oxidative stress, catalase (CAT), Total antioxidant capacity, superoxide dismutase (SOD), and a reduction in glutathione (GSH) levels, while concentrations of malondialdehyde (MDA) increased relative to controls. We also found that cardiac abnormality in PS-MPs treated mice was accompanied by reduced antioxidant capacity, elevated oxidative stress, and elevated apoptotic signaling. Nevertheless, the protective effects of RV against disruptions in endoplasmic reticulum stress and antioxidant profiles resulting from PS-MPs exposure were evident, as RV normalized HSP40, HSP25, and HSP70 levels and enhanced antioxidant defenses. This implies that RV is a promising protective agent against toxicity induced by environmental contaminants such as microplastics.
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Investigating the cardiac damage induced by polystyrene microplastics in rats and the ameliorative effects of Mangosteen Extract via oxidative stress and mitochondrial quality control
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Researchers investigated cardiac damage induced by oral exposure to polystyrene microplastics in rats and evaluated the protective effects of mangosteen extract, focusing on oxidative stress pathways and mitochondrial quality control mechanisms. The study examined how microplastic exposure disrupts cardiac mitochondrial function and whether mangosteen-derived antioxidant compounds can ameliorate these effects.
Low-dose of polystyrene microplastics induce cardiotoxicity in mice and human-originated cardiac organoids
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Researchers found that even low doses of polystyrene microplastics can damage heart tissue in both mice and lab-grown human heart organoids. The microplastics triggered oxidative stress and disrupted energy production in heart cells, leading to inflammation and cell death. This is one of the first studies to show heart-specific toxicity from microplastics at doses meant to reflect realistic human exposure levels.
Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics
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Researchers exposed mice to polystyrene nanoplastics through inhalation and found that even short-term breathing exposure caused heart damage, including inflammation and weakened heart function. The damage got worse with higher doses and longer exposure times, with energy production in heart cells being disrupted through mitochondrial damage. This is one of the first studies to show that breathing in nanoplastics can directly harm the heart, raising concerns about airborne plastic particle exposure in humans.
Protective Effect of Resveratrol on Kidney Disease and Hypertension Against Microplastics Exposure in Male Juvenile Rats
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Researchers investigated whether resveratrol, a natural plant compound, could protect young rats from kidney damage and high blood pressure caused by microplastic exposure. They found that microplastics elevated blood pressure and creatinine levels through oxidative stress, and that resveratrol treatment effectively prevented these effects. The study suggests resveratrol may offer protective benefits against organ damage linked to microplastic exposure, partly by improving gut microbiota balance.
Dissection of the potential mechanism of polystyrene microplastic exposure on cardiomyocytes
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Researchers investigated how polystyrene microplastics affect human heart muscle cells at concentrations reflecting estimated daily human intake levels. They found that the microplastics caused oxidative stress, mitochondrial dysfunction, and disrupted calcium signaling in the cells. The study suggests that microplastic exposure may contribute to cardiovascular risks by directly damaging heart cell function at the cellular level.
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