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Effect of Pineapple Extract on Superoxide Rat Microplastic-induced Liver Injury Model
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Rats were given microplastics by mouth for 35 days, some of them alongside pineapple extract at three doses. Rats that got the extract had higher levels of superoxide dismutase, an antioxidant enzyme, than rats given microplastics alone. The study measured one enzyme in 15 animals.
Background: Microplastic (MPs) are free radicals, which can cause oxidative stress and lead to lipid peroxidation. The body’s efforts to overcome ROS are endogenous antioxidants, namely the enzyme superoxide dismutase (SOD). Pineapple extract, rich in antioxidants such as bromelain, flavonoids, and vitamin C, is expected to overcome exposure to free radicals from MPs. Objective: To assess the effect of pineapple extract on activity level of SOD. Method: Using a true experiment with post-test only control group design. The sample used 15 rats, which were divided into 5 groups; normal group, positive control group that is induced by microplastic (4.200 μg/ml) by oral probe, and the other three groups induced by microplastic personde with pineapple extract at doses of 87.5 mg/kg BW, 175 mg/kg BW and 350 mg/kg BW by oral probe. Treatment was given for 35 days. SOD levels were measured using the ELISA technique. Results and Discussion: A significant difference was observed in mean of SOD with the one-way annova test p: 0.000. The result of linear regression obtained adjusted R2: 0,864 for SOD. The increase in the level of SOD are due to the high level of bromelain, flavonoids, and vitamin C in the pineapple extract, so that it works as an antioxidant to reduce lipid peroxidation and increase the level of antioxidant SOD. Conclusion: There is an effect of giving pineapple extract (Ananas comossus L.) on the level of SOD in rat microplastic-induced liver injury.
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