Papers

61,005 results
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Article Tier 2

Neurotoxicityof Micro- and Nanoplastics: A ComprehensiveReview of Central Nervous System Impacts

This comprehensive review examines neurotoxicity of micro- and nanoplastics, synthesizing evidence that MNP exposure disrupts neural signaling, promotes neuroinflammation, crosses the blood-brain barrier, and may contribute to neurodegenerative and neurodevelopmental disorders.

2025 Figshare
Article Tier 2

Micro- and Nano-plastics may affect the central regulation of reproduction: insights from in vitro and in vivo studies on GnRH neurons.

This review examined how micro- and nanoplastics may interfere with the central nervous system regulation of reproduction, compiling evidence from animal studies. The analysis suggests that plastic particle exposure could disrupt hormonal signaling pathways that control reproductive function.

2024 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

The effects of micro- and nanoplastics on the central nervous system: A new threat to humanity?

This review summarizes growing evidence that micro- and nanoplastics can cross the blood-brain barrier and damage the central nervous system through inflammation, oxidative stress, and disruption of brain chemicals. The authors note that microplastic exposure has been linked to memory and behavior changes in animals and may contribute to neurodegenerative diseases like Parkinson's, though direct human evidence is still limited.

2024 Toxicology 52 citations
Article Tier 2

Micro- and Nano-plastics may affect the central regulation of reproduction: insights from in vitro and in vivo studies on GnRH neurons.

This review examined evidence that micro- and nanoplastics can interfere with the central regulation of reproduction by disrupting hormonal signaling in the brain and endocrine glands. Animal studies show that plastic particle exposure can alter reproductive hormone levels and fertility outcomes.

2024 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Micro-nanoplastics in the central nervous system: Evidence, mechanisms and perspectives

This review examines evidence that micro- and nanoplastics can cross the blood-brain barrier and cause neurotoxicity through oxidative stress, neuroinflammation, and disruption of neurotransmitter signaling. While clinical studies have confirmed the presence of plastic particles in human brain tissue and cerebrospinal fluid, the authors note that methodological limitations and inconsistent quality controls currently prevent establishing a definitive causal link to neurological conditions.

2026 Toxicology
Article Tier 2

The Impact of Microplastics and Nanoplastics on Human Health: A Follow-Up Study Focusing on Endocrine, Nervous, and Immune Systems

This review examines evidence for microplastic and nanoplastic impacts on the endocrine, nervous, and immune systems, documenting how particles detected in human organs can disrupt hormone signaling, induce neuroinflammation, and alter immune function.

2025 International conference KNOWLEDGE-BASED ORGANIZATION
Article Tier 2

Brain under siege: the role of micro and nanoplastics in neuroinflammation and oxidative stress

This review examines emerging evidence that micro- and nanoplastics can cross the blood-brain barrier and accumulate in nervous tissue, potentially triggering neuroinflammation and oxidative stress. Researchers summarized findings showing these particles may act as neurotoxicants that contribute to synaptic dysfunction and pathological changes in brain cells. The study highlights the need for further research into how chronic plastic particle exposure may affect central nervous system health over time.

2026 3 Biotech
Article Tier 2

Micro- and Nanoplastics as Disruptors of the Endocrine System—A Review of the Threats and Consequences Associated with Plastic Exposure

This review summarizes how micro- and nanoplastics carry endocrine-disrupting chemicals that interfere with hormones controlling reproduction, thyroid function, metabolism, and brain development. The reproductive system is especially vulnerable, with studies showing that plastic particle exposure can cause oxidative stress, cell death, and infertility, raising serious concerns given how widespread these particles are in food and the environment.

2025 International Journal of Molecular Sciences 18 citations
Article Tier 2

Microplastics/nanoplastics and neurological health: An overview of neurological defects and mechanisms

This review summarizes evidence that micro and nanoplastics can harm the nervous system, causing developmental abnormalities, brain cell death, neurological inflammation, and potentially contributing to neurodegenerative diseases. Animal studies show that these tiny plastics can cross the blood-brain barrier and accumulate in brain tissue, where they trigger oxidative stress and disrupt normal brain function. While direct evidence in humans is still limited, the findings suggest that chronic microplastic exposure could be a risk factor for neurological health problems.

2024 Toxicology 19 citations
Article Tier 2

From environment to brain: the role of microplastics in neurobehavioral disorders

This review examines how microplastics enter the human body and cross the blood-brain barrier, linking their presence in neural tissue to neurobehavioral disorders through mechanisms including neuroinflammation, oxidative stress, and disruption of neurotransmitter systems.

2025 Frontiers in Neuroscience
Article Tier 2

Deciphering the Neurotoxic Burden of Micro- and Nanoplastics: From Multi-model Experimental Evidence to Therapeutic Innovation

This review summarizes research on how micro- and nanoplastics damage the brain and nervous system, covering evidence from cell studies, animal experiments, and clinical observations. Plastic particles can cross the blood-brain barrier, disrupt the gut-brain connection, cause oxidative stress, and trigger inflammation that leads to memory problems and cognitive decline. The review also discusses potential treatment strategies, making it a useful resource for understanding the brain health risks of plastic exposure.

2025 Molecular Neurobiology 6 citations
Article Tier 2

The plastic brain part II: new insights into micro- and nanoplastics neurotoxicity

This systematic review evaluated neurotoxicity evidence from studies on micro- and nanoplastic (MNP) exposure, covering a rapidly growing body of literature. The authors found consistent evidence of neuroinflammation, oxidative stress, and behavioral disruption across multiple model systems, though dose-response relationships and human relevance remain areas of uncertainty.

2025 Microplastics and Nanoplastics
Article Tier 2

Overall effects of microplastics on brain

This review synthesizes research on how micro- and nanoplastics affect the brain, finding evidence that these particles can cross critical biological barriers including the blood-brain barrier and placenta to reach the central nervous system. Researchers found that once in the brain, microplastics may trigger oxidative stress, inflammation, and disruption of neurotransmitter systems. The study suggests that microplastic exposure represents an emerging concern for neurological health, though more research is needed to fully characterize the risks.

2025 Frontiers in Toxicology 1 citations
Review Tier 2

A review on micro- and nanoplastics in humans: Implication for their translocation of barriers and potential health effects

This review compiles evidence showing that micro- and nanoplastics have been found in human blood, lungs, placenta, and other organs, and can cross protective barriers including the blood-brain and placental barriers. The accumulated evidence links these particles to inflammation, oxidative stress, hormone disruption, and potential effects on reproduction and brain health, though more research is needed to determine exact risk levels.

2024 Chemosphere 35 citations
Review Tier 2

Effects of micro(nano)plastics on the reproductive system: A review

This review summarizes research on how micro and nanoplastics affect the reproductive system in both animal studies and cell experiments. Evidence indicates these particles can cross biological barriers, accumulate in reproductive organs, and disrupt hormones, egg development, and sperm quality. While human studies are still limited, the animal data suggests microplastic exposure may be a meaningful concern for reproductive health.

2023 Chemosphere 42 citations
Article Tier 2

An overview of research on the association between microplastics and central nervous system disorders

This review explores the growing body of evidence linking microplastic exposure to central nervous system disorders. Researchers found that microplastics can enter the body through ingestion, inhalation, and skin absorption, then accumulate in neural tissues where they trigger inflammation, oxidative stress, and neuronal damage. The study aims to provide a scientific foundation for assessing the public health risks of microplastic exposure on brain health.

2025 Frontiers in Public Health 2 citations
Article Tier 2

The plastic brain: neurotoxicity of micro- and nanoplastics

This review examines the emerging evidence that micro- and nanoplastics can reach the brain in both aquatic animals and mammals, potentially causing neurotoxic effects. Researchers found that exposure to these particles induces oxidative stress, inhibits key enzymes involved in nerve signaling, and alters neurotransmitter levels, which may contribute to behavioral changes. The study highlights that systematic research comparing different particle types, sizes, and exposure conditions is urgently needed to understand the neurological risks.

2020 Particle and Fibre Toxicology 691 citations
Article Tier 2

Insights into the toxic effects of micro-nano-plastics on the human brain and their relationship with the onset of neurological diseases: A narrative review.

This review examined toxic effects of micro and nano-plastics (MNPs) on the human brain, linking MNP exposure to neuroinflammation, oxidative stress, disruption of the blood-brain barrier, and progression toward neurodegenerative diseases. The authors synthesized evidence from cell studies, animal models, and emerging human data.

2025 Ageing research reviews
Article Tier 2

Effect of Nanoplastics on Different Biological Systems

This review examines how nanoplastics affect multiple biological systems — including digestive, reproductive, nervous, and immune systems — synthesizing evidence that nanoplastics cross biological barriers and cause oxidative stress, inflammation, and physiological dysfunction across species.

2025 Revista de Gestão Social e Ambiental
Article Tier 2

Micro- and nanoplastics in neurological dysfunction

This review examines growing evidence that micro- and nanoplastic particles can interfere with the nervous system across multiple species, including humans. Researchers found that plastic particles may disrupt cellular metabolism, affect brain development, and increase vulnerability to neurodevelopmental disorders and neurodegeneration. The authors highlight significant knowledge gaps that need to be addressed to understand the long-term neurological impacts of plastic particle exposure.

2026 Trends in Neurosciences
Article Tier 2

Assessing the Impact of Microplastics on Brain Chemistry: The Need for a Comprehensive Policy Framework to Mitigate Toxicity

This review examines the growing evidence that microplastics can cross biological barriers, accumulate in brain tissue, and affect neurological function. Researchers found that microplastic exposure has been linked to neurotoxicity, oxidative stress, and inflammation in the brain, with potential implications for neurotransmitter systems and cognitive function. The study calls for comprehensive regulatory measures to limit microplastic pollution and further research into the long-term neurological health effects.

2024 International Journal of Science and Healthcare Research 2 citations
Review Tier 2

"Unseen Dangers: The Effects of Micro- and Nanoplastics on Human Reproductive Health - A Narrative Review"

This review examines the effects of micro- and nanoplastics on human reproductive health, covering evidence from in vitro, animal, and epidemiological studies showing that plastic particles can disrupt hormone signaling, sperm function, ovarian development, and placental integrity.

2025 Recent Advances in Inflammation & Allergy Drug Discovery
Article Tier 2

Impact of micro- and nanoplastics exposure on human health: focus on neurological effects from ingestion

This review compiles emerging evidence on how ingested microplastics and nanoplastics may affect the brain and nervous system. Researchers found that these particles can disrupt gut bacteria, cross the blood-brain barrier, and accumulate in neural tissue, potentially triggering inflammation, oxidative stress, and protein changes linked to cognitive problems. The study highlights an urgent need for more human research, as initial findings have associated elevated plastic particle levels in brain tissue with neurological concerns.

2025 Frontiers in Public Health 4 citations
Systematic Review Tier 1

The neurotoxic threat of micro- and nanoplastics: evidence from In Vitro and In Vivo models

This systematic review examined 26 studies showing that micro- and nanoplastics can cross into the brain, damage neurons, and trigger inflammation in lab and animal models. These findings raise concerns that long-term plastic exposure could contribute to neurological problems in humans, though more research is needed.

2025 Archives of Toxicology 23 citations