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Microplastics/nanoplastics and neurological health: An overview of neurological defects and mechanisms
Summary
This review summarizes evidence that micro and nanoplastics can harm the nervous system, causing developmental abnormalities, brain cell death, neurological inflammation, and potentially contributing to neurodegenerative diseases. Animal studies show that these tiny plastics can cross the blood-brain barrier and accumulate in brain tissue, where they trigger oxidative stress and disrupt normal brain function. While direct evidence in humans is still limited, the findings suggest that chronic microplastic exposure could be a risk factor for neurological health problems.
The widespread use of plastic products worldwide has brought about serious environmental issues. In natural environments, it's difficult for plastic products to degrade completely, and so they exist in the form of micro/nanoplastics (M/NPs), which have become a new type of pollutant. Prolonged exposure to M/NPs can lead to a series of health problems in humans, particularly toxicity to the nervous system, with consequences including neurodevelopmental abnormalities, neuronal death, neurological inflammation, and neurodegenerative diseases. Although direct evidence from humans is still limited, model organisms and organoids serve as powerful tools to provide important insights. This article summarizes the effects of M/NPs on the nervous system, focusing on cognitive function, neural development, and neuronal death. Mechanisms such as neurotransmitter synthesis and release, inflammatory responses, oxidative stress, the gut-brain axis, and the liver-brain axis are covered. The neurotoxicity induced by M/NPs may exacerbate or directly trigger neurodegenerative diseases and neurodevelopmental disorders. We particularly emphasize potential therapeutic agents that may counteract the neurotoxic effects induced by M/NPs, highlighting a novel future research direction. In summary, this paper cites evidence and provides mechanistic perspectives on the effects of M/NPs on neurological health, providing clues for eliminating M/NP hazards to human health in the future.