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From environment to brain: the role of microplastics in neurobehavioral disorders
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This review examines how microplastics enter the human body and cross the blood-brain barrier, linking their presence in neural tissue to neurobehavioral disorders through mechanisms including neuroinflammation, oxidative stress, and disruption of neurotransmitter systems.
In recent years, the pervasive presence of microplastics has attracted significant attention from the scientific community, particularly concerning their potential implications for human health. Current literature suggests that microplastics may adversely affect the nervous system, with emerging evidence linking them to neurobehavioral disorders. However, many questions remain regarding the pathways of their environmental exposure, the specific effects on neurobehavior, and the underlying mechanisms of their impact. This review aims to explore the routes through which humans are exposed to microplastics, monitor behavioral changes associated with microplastic exposure, and examine how these particles infiltrate the body and traverse the blood-brain barrier. Several perspectives will be considered in assessing the potential mechanisms by which microplastics may influence neurobehavioral disorders, including oxidative stress, neurotransmitter regulation, and neuroplasticity. The article concludes by summarizing the effects of microplastics on neurobehavioral disorders, such as neurodegeneration and mood disorders, while analyzing the latest research findings. The primary objective of this study is to elucidate the neurotoxic effects of microplastics and their potential biological mechanisms, as well as to provide new insights and recommendations for future research in this domain.
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This review examines the environmental pathways by which microplastics enter the human body through ingestion, inhalation, and skin contact, with a particular focus on their effects on the nervous system. Researchers summarize evidence that microplastics can cross the blood-brain barrier and may trigger neuroinflammation and oxidative stress in brain tissue. The study highlights the nervous system as a key area of concern for microplastic-related health research.
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This review examined toxic effects of micro and nano-plastics (MNPs) on the human brain, linking MNP exposure to neuroinflammation, oxidative stress, disruption of the blood-brain barrier, and progression toward neurodegenerative diseases. The authors synthesized evidence from cell studies, animal models, and emerging human data.
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