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61,005 resultsShowing papers similar to Mechanistic insight of neurodegeneration due to micro/nano-plastic-induced gut dysbiosis.
ClearInnovative mechanisms of micro- and nanoplastic-induced brain injury: Emphasis on the microbiota-gut-brain axis
This review summarizes how micro- and nanoplastics may damage the brain through the gut-brain axis, a communication pathway between the digestive system and the nervous system. Nanoplastics can disrupt gut bacteria and weaken the intestinal barrier, potentially sending inflammatory signals to the brain. The authors suggest that targeting gut health could be a way to reduce brain damage caused by nanoplastic exposure.
The microbiota-gut-brain axis in mental and neurodegenerative disorders: opportunities for prevention and intervention.
This review synthesized evidence linking gut microbiome disruption to neurodegenerative and neuropsychiatric disorders via the microbiota-gut-brain axis, identifying opportunities for prevention and intervention. Gut dysbiosis driven by environmental factors—including plastic-associated chemicals—was implicated in conditions like Alzheimer's disease, Parkinson's, and depression.
Microplastics and the gut-brain axis: Unraveling neurotoxic mechanisms and health implications
This review examines how microplastics interact with the gut-brain axis, a communication network linking the digestive system to the central nervous system. Researchers found that microplastics can disrupt intestinal barrier integrity, alter gut microbiota composition, and trigger systemic inflammation that may affect neurotransmitter balance and brain function. The study suggests that chronic microplastic exposure through the diet could contribute to neurological effects through inflammatory and oxidative stress pathways.
Nanoplastic Impact on the Gut-Brain Axis: Current Knowledge and Future Directions
Researchers reviewed the emerging evidence on how nanoplastics may affect the gut-brain axis, the communication pathway between the digestive and nervous systems. Studies indicate that nanoplastic exposure can alter gut microbiota, increase intestinal permeability, trigger oxidative stress and inflammation, and produce neurotoxic and behavioral effects. The review calls for more research given the ubiquitous presence of plastics in the human environment and the potential for nanoplastics to disrupt this critical biological communication pathway.
Molecular insights into physiological impact of micro- and nano-plastics on the digestive system and gut-brain axis
This review evaluates molecular-level evidence on how micro- and nanoplastics affect the digestive system and the gut-brain axis after ingestion through contaminated food and water. The study describes how these particles accumulate in the gastrointestinal tract, liver, and pancreas, causing oxidative stress, gut microbiota disruption, and compromised intestinal barriers, potentially allowing particles to reach the central nervous system and contribute to neuroinflammatory conditions.
Health risk analysis of micro-and nanoplastic exposure via the microbiota-gut-brain axis
This review examines how micro- and nanoplastics that accumulate in the gastrointestinal tract may disrupt the microbiota-gut-brain axis through neural, immune, and endocrine pathways. The study suggests that these particles can interfere with normal gut microbiota function after entering the body through diet, inhalation, and skin contact, potentially inducing or worsening health effects.
Nuclear and Mitochondrial Epigenetic Mechanisms Underlying Neurodegeneration and Gut–Brain Axis Dysregulation Induced by Micro- and Nanoplastics
This review explored how micro- and nanoplastics may drive neurodegeneration through epigenetic changes in both nuclear and mitochondrial DNA. Researchers found that plastic particles can disrupt the gut-brain axis, alter DNA methylation and histone modifications, and potentially accelerate neurodegenerative processes, though the study notes these mechanisms are still being characterized in experimental models.
Micro- and Nanoplastics as Emerging Environmental Materials: GreenChemistry Insights into Gut Microbiota Disruption and Chronic DiseasePathways
Researchers reviewed how micro- and nanoplastics accumulate in the gastrointestinal tract and disrupt gut microbiota composition, finding evidence linking these exposures to reduced microbial diversity, gut barrier dysfunction, systemic inflammation, and potential contributions to chronic diseases including metabolic disorders and neurodegeneration.
Insights into the toxic effects of micro-nano-plastics on the human brain and their relationship with the onset of neurological diseases: A narrative review.
This review examined toxic effects of micro and nano-plastics (MNPs) on the human brain, linking MNP exposure to neuroinflammation, oxidative stress, disruption of the blood-brain barrier, and progression toward neurodegenerative diseases. The authors synthesized evidence from cell studies, animal models, and emerging human data.
Neurotoxicity of Micro- and Nanoplastics: A Comprehensive Review of Central Nervous System Impacts
This comprehensive review summarizes the evidence linking micro- and nanoplastic exposure to damage in the brain and nervous system. The plastics can harm neurons, disrupt the protective blood-brain barrier, trigger brain inflammation, and promote the clumping of proteins associated with diseases like Alzheimer's. The review highlights the gut-brain axis as a key pathway, meaning microplastics swallowed in food and water could affect brain health through the digestive system.
Deciphering the Neurotoxic Burden of Micro- and Nanoplastics: From Multi-model Experimental Evidence to Therapeutic Innovation
This review summarizes research on how micro- and nanoplastics damage the brain and nervous system, covering evidence from cell studies, animal experiments, and clinical observations. Plastic particles can cross the blood-brain barrier, disrupt the gut-brain connection, cause oxidative stress, and trigger inflammation that leads to memory problems and cognitive decline. The review also discusses potential treatment strategies, making it a useful resource for understanding the brain health risks of plastic exposure.
Breaching Barriers: Microplastic Translocation into Human Body Through Food and Implications for Neurodegeneration
This systematic review traced how microplastics enter the body through food and potentially reach the brain. Once ingested, these particles can cross the gut barrier, enter the bloodstream, and accumulate in brain tissue, where they may cause oxidative stress and inflammation that could contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences
This review explores how microplastics, which contaminate drinking water and many common foods, may disrupt the gut and trigger inflammation that affects the brain through the gut-brain connection. The evidence suggests that microplastics could be contributing to the rising rates of brain diseases like Alzheimer's and Parkinson's, though more research in humans is needed to confirm this link.
Elucidating the Neurotoxicopathological Impact of Micro and Nanoplastics: Mechanistic Insights Into Oxidative Stress-mediated Neurodegeneration and Implications for Public Health in a Plastic Pervasive Era
Researchers reviewed the growing evidence linking micro- and nanoplastic exposure to neurodegenerative diseases, identifying oxidative stress, neuroinflammation, DNA damage, and protein misfolding as key mechanisms of harm to the brain. The review highlights critical knowledge gaps — especially around chronic low-dose exposure — and calls for better detection tools and public health policies to address the emerging neurological threat from plastic pollution.
Impact of micro- and nanoplastics exposure on human health: focus on neurological effects from ingestion
This review compiles emerging evidence on how ingested microplastics and nanoplastics may affect the brain and nervous system. Researchers found that these particles can disrupt gut bacteria, cross the blood-brain barrier, and accumulate in neural tissue, potentially triggering inflammation, oxidative stress, and protein changes linked to cognitive problems. The study highlights an urgent need for more human research, as initial findings have associated elevated plastic particle levels in brain tissue with neurological concerns.
From exposure to neurotoxicity induced by micro-nanoplastics with brain accumulation and cognitive decline
This review synthesizes evidence that micro- and nanoplastics can reach the brain by crossing the blood-brain barrier or traveling along nerve pathways, accumulating in regions critical for memory and thinking. Animal studies show that chronic exposure leads to cognitive problems, behavioral changes, and brain changes resembling neurodegenerative diseases, driven by oxidative stress, inflammation, and disruption of the gut-brain connection. The findings raise concern that long-term human exposure to nanoplastics through food and air could contribute to cognitive decline and neurological disease.
Gut microbiota as an emerging target for the health implications of microplastics
This review examines how microplastic exposure disrupts the gut microbiome, finding evidence that microplastics damage intestinal barrier proteins, promote inflammation and oxidative stress, and may drive systemic effects including neurotoxicity and reproductive toxicity through gut-mediated pathways.
The role of gut microbiota in MP/NP-induced toxicity
This review summarizes how micro- and nanoplastics disrupt gut bacteria and why that matters for overall health. The tiny plastic particles change the composition and function of the gut microbiome, which can trigger inflammation, weaken the intestinal barrier, and potentially contribute to diseases beyond the gut through the immune and nervous systems.
The impact of microplastics on neurodegenerative diseases and underlying molecular mechanisms: A narrative review
This review explores how microplastics that accumulate in the environment can reach the brain through inhalation or by crossing the blood-brain barrier. Researchers examined evidence suggesting that microplastics may contribute to the onset or acceleration of neurodegenerative conditions by triggering harmful responses in brain cells. The study calls for stronger environmental policies, better detection methods, and further research into potential therapeutic interventions.
Probiotics an emerging therapeutic approach towards gut-brain-axis oriented chronic health issues induced by microplastics: A comprehensive review
This review examines how microplastics disrupt the gut-brain axis, the communication system between the digestive system and the brain, leading to chronic health problems like inflammation and neurological issues. The authors highlight probiotics as a promising treatment approach, since beneficial bacteria can help repair gut damage caused by microplastic exposure. The findings suggest that supporting gut health through probiotics may help counteract some of the harmful effects of microplastics on both digestion and brain function.
Oxidized/unmodified-polyethylene microplastics neurotoxicity in mice: Perspective from microbiota-gut-brain axis
Mice exposed to both regular and environmentally weathered polyethylene microplastics developed brain and gut damage, including behavioral changes, weakened gut and blood-brain barriers, and inflammation -- with weathered microplastics causing even more harm. Importantly, treatment with a probiotic (Lactobacillus) and a prebiotic partially reversed these effects, suggesting that gut-friendly supplements might help protect against microplastic-related brain and intestinal damage.
Microplastics and human health: unveiling the gut microbiome disruption and chronic disease risks
This review summarizes evidence that microplastics disrupt the gut microbiome, the community of bacteria in our digestive system that plays a key role in immunity, metabolism, and overall health. By altering gut bacteria balance and triggering inflammation, microplastic exposure may contribute to chronic conditions including inflammatory bowel disease, metabolic disorders, and potentially even neurological problems through the gut-brain connection.
From environment to brain: the role of microplastics in neurobehavioral disorders
This review examines how microplastics enter the human body and cross the blood-brain barrier, linking their presence in neural tissue to neurobehavioral disorders through mechanisms including neuroinflammation, oxidative stress, and disruption of neurotransmitter systems.
Neurotoxicities induced by micro/nanoplastics: A review focusing on the risks of neurological diseases
This review summarizes evidence that micro- and nanoplastics can reach the brain through the bloodstream and nerve pathways, where they trigger oxidative stress, inflammation, and cell damage that may contribute to neurodegenerative diseases. The particles are found in air, water, soil, and food, meaning humans are constantly exposed through breathing, eating, and skin contact, making brain effects a serious long-term concern.