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The impact of microplastics on neurodegenerative diseases and underlying molecular mechanisms: A narrative review
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This review explores how microplastics that accumulate in the environment can reach the brain through inhalation or by crossing the blood-brain barrier. Researchers examined evidence suggesting that microplastics may contribute to the onset or acceleration of neurodegenerative conditions by triggering harmful responses in brain cells. The study calls for stronger environmental policies, better detection methods, and further research into potential therapeutic interventions.
Abstract The widespread production and disposal of plastics have led to an alarming accumulation of microplastics (MPs) in the environment with significant implications for human health. MPs have infiltrated and accumulated in various ecosystems around the world and consequently in human bodies, posing severe health risks, including the onset of, and acceleration of, neurodegenerative diseases. This review article explores the sources and routes of transmission by which MPs enter the central nervous system, including inhalation and direct penetration of the blood–brain barrier, detection strategies such as engineered nanostructures and gold nanoparticles, and the role of glial cells in exacerbating neurodegenerative diseases such as Alzheimer’s diseases, Parkinson’s diseases, and multiple sclerosis in the presence of MPs. Further, this paper emphasizes a call for action for further investigation and prevention strategies of the impact of MPs including environmental policy changes, advanced detection methods, and potential therapeutic interventions.
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From the Environment to Molecular Interactions of Nanoplastics: Unraveling the Neurotoxic Impacts and the Implications in Neurodegenerative Processes
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Neurotoxicities induced by micro/nanoplastics: A review focusing on the risks of neurological diseases
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This review examines emerging evidence that micro- and nanoplastics can cross the blood-brain barrier and accumulate in nervous tissue, potentially triggering neuroinflammation and oxidative stress. Researchers summarized findings showing these particles may act as neurotoxicants that contribute to synaptic dysfunction and pathological changes in brain cells. The study highlights the need for further research into how chronic plastic particle exposure may affect central nervous system health over time.
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