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20 resultsShowing papers similar to MassBalance Tracing of In Vivo Biodistribution,Relocation, and Excretion of Europium-Doped Micro/Nanoplastics inRats
ClearMass Balance Tracing of In Vivo Biodistribution, Relocation, and Excretion of Europium-Doped Micro/Nanoplastics in Rats
Scientists injected tiny plastic particles into rats and tracked where they went in the body for three months. Most plastic particles collected in the liver and spleen, with smaller particles being harder for the body to get rid of—only 80% of the smallest particles were eliminated compared to just 15% of larger ones. This suggests that microplastics from food, water, and air could build up in our organs over time, though the long-term health effects are still unknown.
Semiquantitative assessment of the distribution of microplastic particles in the body during acute exposure
Researchers developed and validated a semi-quantitative method to assess microplastic distribution across organs in rats under acute exposure conditions, using fluorescent particles of three sizes (100, 500, 1000 nm) to map accumulation patterns — finding size-dependent biodistribution with smaller particles reaching more tissues.
Biodistribution of europium-doped polystyrene nanoplastics in a model invertebrate organism
This study used europium-doped polystyrene nanoplastics tracked by laser ablation inductively coupled plasma mass spectrometry to map biodistribution of plastic nanoparticles in a model invertebrate organism. The labeled tracer approach enabled precise organ-level mapping of nanoplastic distribution, revealing where plastic nanoparticles accumulate after exposure.
Biodistribution of nanoplastics in mice: advancing analytical techniques using metal-doped plastics
Researchers developed a new analytical method using palladium-doped nanoplastics to track where plastic particles go in the body after ingestion in mice. They found that after short-term exposure, most particles passed through the digestive system and were excreted, but longer-term exposure led to accumulation in body tissues. The study advances the ability to detect and trace nanoplastics at extremely small concentrations in biological samples.
The Uptake and Distribution Evidence of Nano- and Microplastics in vivo after a Single High Dose of Oral Exposure.
This in vivo study provided evidence on the uptake and organ distribution of nano- and microplastics following a single high-dose administration, finding that nanoplastics translocated rapidly to multiple organs through blood circulation while only small amounts of larger microplastics penetrated organs.
Blood uptake and urine excretion of nano- and micro-plastics after a single exposure.
Mice exposed to polystyrene nanoparticles (100 nm) and microparticles (3 µm) via different routes showed that smaller particles appeared rapidly in blood and were detected in urine, while larger particles cleared more slowly. The study provides direct evidence that nanoplastics can cross biological barriers and enter circulation, with potential for distribution throughout the body.
Comparison of PET tracing and biodistribution between 64Cu-labeled micro-and nano-polystyrene in a murine inhalation model
Using advanced PET imaging in mice, researchers tracked where inhaled micro and nanoplastics traveled in the body and found that nano-sized particles cleared from the lungs much faster than micro-sized ones but accumulated more in the liver, spleen, and other organs. Micro-sized particles stayed in the lungs longer, with peak retention at 24 hours, while nano-sized particles spread quickly throughout the body. This is one of the first studies to directly visualize how inhaled plastic particles distribute through living mammals, confirming that smaller particles pose a greater risk of reaching organs beyond the lungs.
Imaging and quantifying the biological uptake and distribution of nanoplastics using a dual-functional model material
This study used advanced imaging techniques to visualize and quantify nanoplastic uptake and distribution in biological systems, tracking particle translocation from exposure routes into tissues and characterizing intracellular localization.
Biodistribution of europium-doped polystyrene nanoplastics in a model invertebrate organism
This study tracked the biodistribution of europium-labeled polystyrene nanoplastics in a model invertebrate using laser ablation ICP-MS, overcoming the analytical challenge of distinguishing nanoplastics from surrounding biological material in tissues. Organ-specific accumulation patterns were mapped, providing mechanistic data on nanoplastic fate after uptake in a small animal model.
In Vivo Tissue Distribution of Microplastics and the Systemic Metabolic Changes After Gastrointestinal Exposure in Mice
Mice exposed to microplastics via the gastrointestinal route showed systemic distribution of particles to multiple organs and measurable changes in metabolic pathways, providing early in vivo evidence of systemic impacts from plastic ingestion.
Unraveling the in vivo fate of inhaled micro- and nanoplastics with PET imaging
Using advanced PET imaging, researchers tracked what happens to inhaled and injected micro and nanoplastics inside living mice for the first time. They found that nanoplastics largely avoided being captured by immune cells in the lungs and could travel to other organs, while both sizes accumulated heavily in the liver and spleen after entering the bloodstream. This study provides direct evidence that inhaled plastic particles can redistribute throughout the body, which is important for understanding how airborne microplastics might affect human health.
In Vivo Tissue Distribution of Microplastics and Systemic Metabolomic Alterations After Gastrointestinal Exposure
Researchers fed mice a mixture of common microplastics and then tracked where the particles ended up in the body and how they affected metabolism. They found that ingested microplastics crossed the gut barrier and accumulated in the liver, kidneys, and other tissues, causing measurable changes in metabolic pathways. The study provides evidence that microplastic exposure through the digestive system can lead to widespread tissue distribution and systemic metabolic disruption in mammals.
생물에 의한 미세플라스틱의 섭취(ingestion), 체내 이동(translocation), 배설(egestion)에 관한 고찰 -생물은 미세플라스틱을 섭취 후 배설하는가?-
This Korean review synthesizes evidence on how microplastics are ingested, transported through the body, and excreted by organisms, with implications for predicting microplastic behavior in humans. The review shows that ingested microplastics can translocate from the gut to lymph nodes, liver, kidney, spleen, heart, and brain via the circulatory system.
Quantification and visualization of micro- and nano-plastics transfer from maternal to fetal: A rat model study
Using europium-labeled nanoplastics and microplastics administered to pregnant rats, researchers quantitatively tracked maternal-to-fetal transfer using electron microscopy and mass spectrometry, providing first direct quantitative evidence of how these particles cross the placental barrier.
Analysis of Biodistribution and in vivo Toxicity of Varying Sized Polystyrene Micro and Nanoplastics in Mice
This study found that smaller plastic particles spread more widely through the bodies of mice and caused more organ damage than larger ones, particularly in the liver, kidneys, and heart. Nanoplastics (under 1 micrometer) were especially concerning because they crossed biological barriers more easily than microplastics. The results suggest that the tiniest plastic particles in our environment may pose the greatest health risks.
Distribution and Tissue Damage After a Single Microplastic Exposure in Mice
Researchers administered fluorescent microplastics to mice by oral gavage and tracked their distribution through the body over several hours. They found direct evidence of microplastic particles in the blood, lungs, brain, kidneys, liver, and spleen, with fluorescence peaking at two hours after exposure. Histological examination revealed mild tissue damage including congestion in the liver and lungs, providing evidence that ingested microplastics can enter the bloodstream and reach multiple organs.
Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure
Researchers fed mice polystyrene microplastics of two sizes and tracked where the particles accumulated in the body, finding them in the liver, kidneys, and gut with distribution patterns depending on particle size. Biochemical analysis revealed that microplastic exposure disrupted energy and fat metabolism, caused oxidative stress, and altered markers of neurotoxicity in the blood. The study provides evidence that microplastics can accumulate in mammalian tissues and may pose widespread health risks.
Evidence on Invasion of Blood, Adipose Tissues, Nervous System and Reproductive System of Mice After a Single Oral Exposure: Nanoplastics versus Microplastics.
Researchers found that after a single oral exposure in mice, nanoplastics were rapidly absorbed into the blood, accumulated in fat tissues, and crossed both the blood-brain and blood-testis barriers. The study demonstrated that the distribution and behavior of plastic particles in mammals is strongly dependent on particle size, with nanoplastics showing substantially greater tissue penetration than microplastics.
Detection of nano- and microplastics in mammalian tissue
Researchers detected nano- and microplastics in mammalian tissue samples using sensitive analytical techniques, confirming particle accumulation in organs beyond the gastrointestinal tract. The findings demonstrate that small plastic particles can translocate from the gut to systemic tissues.
PET Tracing of Biodistribution for Orally Administered 64Cu-Labeled Polystyrene in Mice
Researchers used PET imaging to track the real-time biodistribution of orally administered radiolabeled polystyrene microplastics in mice. The study found that microplastics were absorbed from the gastrointestinal tract and distributed to various organs, providing direct visual evidence of how ingested plastic particles can travel through the body.