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Quantification and visualization of micro- and nano-plastics transfer from maternal to fetal: A rat model study

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Peijnenburg, Yongming Luo, Yudong Feng, Qing Wang Qing Wang Yongming Luo, Qing Wang Yongming Luo, Xiangliang Pan, Qing Wang Yongming Luo, Yongming Luo, Yongming Luo, Quanquan Guan, Willie J.G.M. Peijnenburg, Qing Xu, Xiangliang Pan, Xiangliang Pan, Chen Tu, Xiangliang Pan, Chen Tu, Chen Tu, Chen Tu, Chen Tu, Xiangliang Pan, Xiangliang Pan, Chen Tu, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Xiangliang Pan, Willie J.G.M. Peijnenburg, Xiangliang Pan, Willie J.G.M. Peijnenburg, Chen Tu, Chen Tu, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Xiangliang Pan, Xiangliang Pan, Qing Wang Xiangliang Pan, Xiangliang Pan, Xiangliang Pan, Yongming Luo, Qing Wang Yudong Feng, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Ruijie Li, Ruijie Li, Chen Tu, Chen Tu, Xiangliang Pan, Xiangliang Pan, Xiangliang Pan, Xiangliang Pan, Xiangliang Pan, Xiangliang Pan, Yongming Luo, Yongming Luo, Yongming Luo, Yongming Luo, Yankai Xia, Chen Tu, Chen Tu, Chen Tu, Chen Tu, Willie J.G.M. Peijnenburg, Xiangliang Pan, Xiangliang Pan, Chen Tu, Xiangliang Pan, Chen Tu, Xiangliang Pan, Chen Tu, Chen Tu, Willie J.G.M. Peijnenburg, Xiangliang Pan, Xiangliang Pan, Willie J.G.M. Peijnenburg, Xiangliang Pan, Chen Tu, Qing Wang Chen Tu, Xiangliang Pan, Willie J.G.M. Peijnenburg, Qing Wang Xiangliang Pan, Qing Wang Chen Tu, Xiangliang Pan, Xiangliang Pan, Qing Wang Willie J.G.M. Peijnenburg, Chen Tu, Chen Tu, Chen Tu, Xiangliang Pan, Chen Tu, Yankai Xia, Chen Tu, Willie J.G.M. Peijnenburg, Chen Tu, Chen Tu, Chen Tu, Chen Tu, Willie J.G.M. Peijnenburg, Yongming Luo, Yankai Xia, Qing Wang Qing Wang Chen Tu, Willie J.G.M. Peijnenburg, Yongming Luo, Willie J.G.M. Peijnenburg, Qing Wang Yongming Luo, Qing Wang Yongming Luo, Chen Tu, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Yongming Luo, Willie J.G.M. Peijnenburg, Yongming Luo, Xiangliang Pan, Yongming Luo, Qing Xu, Yongming Luo, Qing Wang Xiangliang Pan, Quanquan Guan, Willie J.G.M. Peijnenburg, Qing Wang Willie J.G.M. Peijnenburg, Yongming Luo, Qing Wang Qing Wang Xiangliang Pan, Xiangliang Pan, Xiangliang Pan, Yongming Luo, Xiangliang Pan, Qing Wang Xiangliang Pan, Chen Tu, Yankai Xia, Willie J.G.M. Peijnenburg, Yongming Luo, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Xiangliang Pan, Yongming Luo, Willie J.G.M. Peijnenburg, Qing Wang Jamie L. Inman, Qing Wang Chen Tu, Willie J.G.M. Peijnenburg, Chen Tu, Yongming Luo, Chen Tu, Yongming Luo, Yongming Luo, Antoine M. Snijders, Yongming Luo, Xiangliang Pan, Qing Wang Yongming Luo, Qing Wang Xiangliang Pan, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Yongming Luo, Willie J.G.M. Peijnenburg, Qing Wang Willie J.G.M. Peijnenburg, Bo Hang, Qing Wang Qing Wang Yongming Luo, Qing Wang Xiangliang Pan, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Qing Xu, Chen Tu, Yongming Luo, Chen Tu, Willie J.G.M. Peijnenburg, Yankai Xia, Qing Wang Di Wu, Yankai Xia, Yongming Luo, Qing Wang

Summary

Using europium-labeled nanoplastics and microplastics administered to pregnant rats, researchers quantitatively tracked maternal-to-fetal transfer using electron microscopy and mass spectrometry, providing first direct quantitative evidence of how these particles cross the placental barrier.

Body Systems

Reproductive

Models

Rat

Study Type In vivo

Micro- and nano-plastics (MNPs) are emerging pollutants, with growing evidence suggesting the presence of MNPs in human tissues. However, there is a notable lack of quantitative data regarding the maternal-embryonic transfer of MNPs. In this study, rats were utilized as model animals and were orally exposed to europium-labeled nanoplastics (Eu-NPs, 0.2 μm) and microplastics (Eu-MPs, 2 μm) over 18 days, from gestation day 0.5 to day 18.5. High-angle annular dark-field scanning transmission electron microscopy and inductively coupled plasma mass spectrometry were employed to qualitatively and quantitatively track the maternal-fetal transfer of MNPs. The results indicate that the transfer of MNPs from the placenta to the fetus exhibits size-dependent. Specifically, the transfer rate from the placenta to fetus reached 0.48 %, significantly higher than that of Eu-MPs. Notably, MNPs underwent deformation and fragmentation during in vivo transfer. The study also demonstrated that MNPs primarily accumulated in the rat decidua, where they compressed capillaries, potentially impairing fetal growth. These findings provide new insights into the maternal-fetal transfer of MNPs and offer a novel perspective for further investigating the impact of MNPs on maternal and fetal health.

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