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61,005 resultsShowing papers similar to Adverse outcome pathways potentially related to hazard identification of microplastics based on toxicity mechanisms
ClearMicro- and nano-plastics activation of oxidative and inflammatory adverse outcome pathways
This review maps the biological harm caused by micro- and nanoplastics to formal toxicity pathways, finding that oxidative stress is a common starting point for damage at every level from cells to whole organisms. Researchers found that in ecological settings, this oxidative damage cascades into growth inhibition and behavioral changes, while in human health contexts it may trigger inflammatory responses. The study highlights that more mammalian research is needed to fully define the health risks of plastic particle exposure.
The emerging role of microplastics in systemic toxicity: Involvement of reactive oxygen species (ROS)
This review examines how microplastics and nanoplastics cause damage at every level of biological complexity -- from molecules and cells to organs and organ systems -- primarily by generating harmful molecules called reactive oxygen species (ROS). These ROS trigger chain reactions including DNA damage, protein breakdown, and cell death pathways, which may contribute to inflammation and disease in exposed organisms, including humans.
The detrimental effects of micro-and nano-plastics on digestive system: An overview of oxidative stress-related adverse outcome pathway
This review maps out how micro and nanoplastics damage the digestive system, identifying oxidative stress as the initial trigger that leads to inflammation, cell death, disrupted gut bacteria, and metabolic disorders. The authors use an adverse outcome pathway framework to connect molecular-level damage to broader health consequences. The findings suggest that ongoing microplastic exposure through food and water could contribute to digestive health problems.
Toxicity and mechanism analysis of microplastics
This review summarized experimental evidence on the toxicity and mechanisms of action of microplastics across animal models, covering effects from ingestion including organ damage, oxidative stress, and immune disruption. The synthesis aimed to inform risk assessment for environmental and human health impacts of microplastic exposure.
Microplastics, Endocrine Disruptors, and Oxidative Stress: Mechanisms and Health Implications
This review examines how microplastics and nanoplastics trigger oxidative stress as a central mechanism of toxicity across multiple organ systems, including reproductive, cardiovascular, hepatic, and neurological tissues. The study highlights that these particles often carry endocrine-disrupting chemicals like bisphenol A and phthalates, which together generate reactive oxygen species, impair mitochondrial function, and compromise antioxidant defenses.
Reproductive toxicity of microplastics role of oxidative stress in cellular and molecular damage
This review synthesizes in vitro, in vivo, and epidemiological evidence on how microplastics cause reproductive toxicity, focusing on oxidative stress as the central mechanism. MPs infiltrate reproductive tissues, generate reactive oxygen species, and disrupt gametogenesis, hormone regulation, and embryonic development across multiple species.
Recent consequences of micro-nanaoplastics (MNPLs) in subcellular/molecular environmental pollution toxicity on human and animals
This review examines the subcellular and molecular mechanisms by which micro- and nanoplastics cause toxicity in humans and animals, focusing on oxidative stress, inflammation, cell death pathways, and endocrine disruption at the cellular level.
Adverse outcome pathways and in vitro toxicology strategies for microplastics hazard testing
Researchers proposed using the adverse outcome pathway framework to systematically assess microplastic hazards to human health, identifying mechanistic parallels with other well-characterized stressors that can guide prioritization of in vitro testing strategies for particles of different sizes, shapes, and chemistries.
Oxidative and Inflammatory Potential of Nano/Microplastics in Living Organisms
This review examines the growing body of evidence that microplastics and nanoplastics trigger oxidative stress and inflammatory responses across a wide range of animals, though the findings are often inconsistent and sometimes contradictory. The authors conclude that plastic particle weathering can alter these effects in complex ways, and call for standardized, systematic research to establish clearer dose-response relationships before firm regulatory conclusions can be drawn.
Mechanisms of Cell Toxicity Caused by Degraded Microplastics
This review examined the molecular and cellular mechanisms by which degraded microplastics cause toxicity, focusing on how physical and chemical changes during environmental weathering alter plastic particle biological activity. The paper discussed oxidative stress, membrane disruption, and inflammatory pathways as key toxicity mechanisms of degraded microplastic fragments.
A meta-analysis-based adverse outcome pathway for the male reproductive toxicity induced by microplastics and nanoplastics in mammals
This meta-analysis of 39 studies mapped the adverse outcome pathway for microplastic and nanoplastic-induced male reproductive toxicity in mammals. Increased reactive oxygen species triggers a cascade of cellular damage including mitochondrial dysfunction, sperm DNA damage, and disrupted hormone signaling, ultimately leading to reduced sperm quality, impaired spermatogenesis, and decreased testosterone levels.
Do microplastics induce oxidative stress in marine invertebrates?
This review examined whether marine invertebrates exposed to microplastics show evidence of oxidative stress — a common cellular response to toxic injury — finding support for this effect across multiple species and polymer types. Oxidative stress is a key mechanism by which microplastics may harm marine organisms.
Origin, environmental presence and health effects of microplastics
This review synthesizes current knowledge on the origins, environmental distribution, and health effects of microplastics, covering exposure pathways (ingestion, inhalation, dermal contact) and associated health risks including oxidative stress, inflammation, metabolic disruption, neurotoxicity, reproductive toxicity, and potential carcinogenicity.
Toxicity of metal-based nanoparticles: Challenges in the nano era
This review covers the toxic effects of metal-based nanoparticles on human health, including how they cause oxidative stress, inflammation, DNA damage, and organ dysfunction. While focused on engineered nanoparticles rather than microplastics directly, the toxicity pathways described overlap significantly with those triggered by nanoplastic exposure. Understanding these shared mechanisms helps explain how nano-scale particles of any kind, including nanoplastics, may harm the body.
Cellular and Systemic Effects of Micro- and Nanoplastics in Mammals—What We Know So Far
This review summarized known cellular and systemic effects of micro- and nanoplastics in mammals, finding that while ingestion is common, knowledge of health impacts remains limited, with oxidative stress and inflammation as the most reported biological responses.
Hazard Effects and Mechanisms of Action of Microplastics on Health
This review examines the hazard mechanisms by which microplastics smaller than 5 mm affect biological systems, covering cellular and molecular mechanisms including cytotoxicity, tissue damage, oxidative stress, inflammation, and endocrine disruption after ingestion, inhalation, or skin contact. The authors assess the current evidence base for direct health effects and identify gaps in understanding dose-response relationships for human exposure.
The reactive oxygen species as pathogenic factors of fragmented microplastics to macrophages
Researchers tested how fragment-shaped microplastics from polypropylene and polystyrene affect different human cell types and found that immune cells called macrophages were the most vulnerable. The toxicity was driven by the microplastics' ability to generate reactive oxygen species (ROS), and interestingly, weathered plastics were less toxic because environmental aging made them better at binding protective proteins. The study suggests that macrophages are a primary target cell for ingested microplastics and that oxidative stress is a key mechanism of their toxicity.
Toxicity and biomarkers of micro-plastic in aquatic environment: a review
This review synthesizes literature on the toxicity and biomarker responses of aquatic organisms to microplastics, covering uptake routes, bioavailability factors, and both lethal and sub-lethal effects. It highlights oxidative stress, endocrine disruption, and genotoxicity as consistent toxic mechanisms across diverse aquatic species.
Cellular and Systemic Impacts of Microplastics and Nanoplastics
This review synthesized evidence on how micro- and nanoplastics cause cellular and systemic harm through inflammation, oxidative stress, mitochondrial dysfunction, and endocrine disruption across multiple organ systems. The authors emphasize that exposure is ubiquitous and that health impacts are no longer speculative.
Adverse Outcome Phenomena and Toxicity Mechanisms of Micro and Nanoplastics in Human Health
This review examines the growing evidence that micro- and nanoplastics can enter the human body through food, water, and air, and may contribute to harmful biological effects. Researchers found that these tiny particles can trigger oxidative stress, inflammation, and disruption of hormonal and immune systems in laboratory studies. The study highlights the need for a unified research approach to better understand how microplastic exposure may affect long-term human health.
Toxicity Induced by Micro-and Nanoplastics through Oxidative Stress: The Role of Co-Exposure to Other Chemical Pollutants
This review examined how micro- and nanoplastics cause oxidative stress — a form of cellular damage — in living organisms, particularly when combined with other chemical pollutants in the environment. Co-exposure to microplastics and chemicals like pesticides or heavy metals tends to be more damaging than either pollutant alone.
Microplastics and human health: unraveling the toxicological pathways and implications for public health
This review pulls together recent research on how microplastics enter the human body and cause cellular damage through inflammation, oxidative stress, and direct cell injury. The authors highlight that microplastics can also amplify the harmful effects of other environmental pollutants they carry, creating combined health risks that are greater than either threat alone.
Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects
This review examines the biological mechanisms by which micro- and nanoplastics may cause harm in humans, including oxidative stress, inflammation, disruption of protective barriers, and immune system problems. Evidence from lab and animal studies suggests these particles can affect the gut, heart, brain, and reproductive systems, though human data is still limited to detecting plastics in tissues rather than proving they cause specific diseases. The authors highlight that most studies use higher doses than people actually encounter, making it important to develop research models that better reflect real-world chronic exposure.
Exploring toxicological pathways of microplastics and nanoplastics: Insights from animal and cellular models
This review examines what animal and cell studies have revealed about how microplastics and nanoplastics cause harm at the molecular level, including promoting inflammation, oxidative stress, and cell death. Most research has focused on reproductive toxicity and polystyrene particles, while effects on the gut, brain, and heart remain understudied. The authors note that many experiments use unrealistic concentrations and synthetic particles, making it difficult to apply the results to real-world human exposure.