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61,005 resultsShowing papers similar to Oncogenic Role of miRNA by Environmental Exposure to Plasticizers: A Systematic Review.
ClearNanoplastics: Focus on the role of microRNAs and long non-coding RNAs
This review explored how nanoplastics may affect gene expression through epigenetic mechanisms, focusing on their potential to alter microRNA and long non-coding RNA regulation, which could contribute to chronic diseases including cancer.
From exposure to oncogenesis: a review on the multifaceted roles of microplastics in tumor initiation and progression
This review examined the evidence linking microplastic exposure to tumor initiation and progression, covering physical, chemical, and inflammatory mechanisms by which MPs may promote oncogenesis. The authors conclude that while current evidence is largely preclinical, accumulating data warrant serious concern about microplastics as environmental carcinogens.
Rising Concern About the Carcinogenetic Role of Micro-Nanoplastics
This review examined the emerging concern that micro- and nanoplastics may play a role in cancer development, either directly or by carrying chemical carcinogens into the body. Researchers noted that while direct evidence is still limited, the rising incidence of certain cancers in younger populations alongside increasing environmental plastic contamination has raised important questions. The study calls for more focused research to understand whether long-term microplastic exposure may contribute to cancer risk and what preventive measures might be warranted.
In-silico pharmacological insights into the therapeutic potential of microRNAs for microplastic-associated cancers
Researchers systematically screened published literature to identify cancer-related genes altered by microplastic exposure, then computationally evaluated microRNAs with anticancer activity that could target those genes, finding potential miRNA-based therapeutic candidates across breast, gastric, and other microplastic-associated tumor types.
Microplastics as emerging carcinogens: from environmental pollutants to oncogenic drivers
This review examines growing evidence that microplastics and nanoplastics may play a role in cancer development, with these particles found in human tumor tissues from the lungs, colon, stomach, breast, and other organs. The particles appear to promote cancer through chronic inflammation, oxidative stress, DNA damage, and disruption of key cancer-related signaling pathways. While direct proof of causation in humans is still lacking, the accumulating evidence from lab studies, animal experiments, and human tissue analysis suggests microplastics deserve serious attention as potential contributors to cancer risk.
From Exposure to Oncogenesis: the Role of Microplastics and Associated Pollutants in Cancer - a Literature Review
This literature review examined the growing evidence linking microplastic exposure to cancer development. Microplastics have been found in human lung, liver, and colon tissue, and research suggests they may promote cancer through chronic inflammation, oxidative stress, and by carrying known carcinogens like heavy metals and persistent organic pollutants into the body.
The impact of environmental microplastics as emerging carcinogens: A public health concern
This review investigated the mechanisms by which microplastics may contribute to cancer development, examining studies from 2010 to 2024. Researchers found that microplastics can induce oxidative stress, inflammation, and DNA damage through multiple pathways, and that human exposure occurs primarily through ingestion, inhalation, and dermal contact. The study suggests that microplastics represent an emerging class of environmental concern warranting further investigation into their long-term health effects.
The Relationship Between Microplastics and Nanoplastics with Cancer: An Emerging Health Concern
This review explores the emerging relationship between micro- and nanoplastic exposure and cancer risk in humans. Researchers summarized evidence suggesting that microplastics can carry carcinogenic substances and may trigger inflammatory and oxidative stress pathways linked to tumor development. The study highlights that while early evidence raises concern, more research is needed to establish clear causal connections between plastic particle exposure and specific cancer types.
Micro(nano)plastics pollution and human health: How plastics can induce carcinogenesis to humans?
This review examines how microplastics and nanoplastics enter the human body through food, water, and air, and how they may contribute to cancer development. Common plastic types like polystyrene and PVC, along with toxic chemicals they carry such as PAHs and PCBs, have been linked to DNA damage, oxidative stress, and inflammation, all of which can promote cancer. The paper highlights that while the evidence is growing, more research is needed to understand the full cancer risk from chronic microplastic exposure.
Rising Concern About the Carcinogenetic Role of Micro‐Nanoplastics
This review raised concerns about the carcinogenic potential of micro- and nanoplastics, synthesizing evidence that these particles can induce DNA damage, oxidative stress, and cellular transformation. It called for accelerated research into whether microplastic exposure increases human cancer risk.
The alarming link between environmental microplastics and health hazards with special emphasis on cancer
This review describes how microplastics enter the human body through the nose, skin, and mouth, then penetrate cells where they can alter gene expression, fuel inflammation, disrupt hormone signaling, and promote uncontrolled cell growth. Studies have linked microplastic exposure to cancers of the lungs, blood, breast, prostate, and ovaries, though the precise molecular mechanisms still need further investigation.
Exposure and inhaling of microplastics: An evidence of cause of cancer
This review examined microplastic inhalation as a potential cause of cancer, surveying pathways by which inhaled MP particles accumulate in lung tissue and drive oncogenic processes through inflammation, oxidative damage, and DNA strand breaks. The evidence reviewed supports classifying microplastic inhalation as an emerging environmental cancer risk factor.
Insights into the potential carcinogenicity of micro- and nano-plastics.
This review examined existing evidence on the carcinogenic potential of micro- and nano-plastics, finding studies demonstrating genotoxicity, oxidative DNA damage, disruption of cell signaling, and tumor-promoting effects, while noting that direct human carcinogenicity data remain limited and mechanistic pathways require further investigation.
The Impact of Environmental Factors on Cancer Risk: A Comprehensive Review
This paper is not about microplastics in a specific research sense; it is a broad review of how environmental factors influence cancer risk, with no substantive microplastic content evident from the available abstract.
Exposure and inhaling of microplastics: An evidence of cause of cancer
This review examined the evidence linking microplastic inhalation to cancer risk, covering how inhaled MPs accumulate in the lungs, trigger chronic inflammation, oxidative stress, and DNA damage, and may contribute to lung carcinogenesis. The authors identified microplastic inhalation as an underappreciated occupational and environmental cancer risk.
Microscopic menace: exploring the link between microplastics and cancer pathogenesis
This review examines the growing evidence linking microplastic exposure to cancer development in humans. Microplastics can accumulate in the body and trigger inflammation, oxidative stress, and other biological changes associated with tumor growth. While more clinical research is needed, the review highlights that microplastics should be taken seriously as a potential factor in cancer risk.
Derivatives of Plastics as Potential Carcinogenic Factors: The Current State of Knowledge
Researchers reviewed the current evidence on micro- and nanoplastics as potential carcinogenic substances that may cause DNA damage. The review found correlations between exposure to micro- and nanoplastic particles and the onset of several cancers, though the study notes that more research is needed to establish clear causal relationships between plastic particle exposure and cancer development.
Plastic pollution-Microplastics: Cancer related issues
This review examines how microplastics may contribute to cancer risk, summarizing evidence that ingested microplastics can cross the gut epithelium, accumulate in tissues, induce oxidative stress and inflammation, and carry carcinogenic chemical additives.
Evaluating the relationship between microplastics and nanoplastics contamination and diverse cancer types development
This review examines growing evidence that micro- and nanoplastics found in human tissues may contribute to cancer development through several pathways. These tiny particles can generate harmful molecules called reactive oxygen species, cause chronic inflammation, and disrupt cell growth signals, all of which are known to promote cancer. While long-term, high-level exposure likely poses the greatest risk, more research is needed to understand the full cancer-related dangers of microplastic exposure.
Microplastics and Cancer: A Comprehensive Review of Their Impact on Tumor Progression and Mechanisms of Carcinogenesis
This comprehensive review examines the growing body of evidence linking microplastic exposure to various types of cancer, including colorectal, lung, liver, and breast cancers. Researchers found that microplastics and nanoplastics may promote tumor progression through mechanisms including oxidative stress, chronic inflammation, and disruption of cellular signaling pathways. While the evidence is still emerging, the study highlights the need for further research into the potential cancer-related risks of widespread microplastic exposure.
The Impact of Microplastics on Biological Systems: A Focus on Extracellular Vesicles and miRNA Profiles
This review examines how microplastics affect biological systems with a focus on extracellular vesicles, discussing how MP exposure alters vesicle release and composition in ways that may propagate cellular stress signals throughout tissues and contribute to systemic health effects.
Microplastics and cancer
This review examines evidence linking microplastics to cancer risk, noting that microplastics have been detected at higher concentrations in human tumor tissues than adjacent healthy tissue, and that they can act as vectors for carcinogens while inducing oxidative stress, inflammation, and genotoxicity.
Micro- and Nanoplastics in the Environment: Current State of Research, Sources of Origin, Health Risks, and Regulations—A Comprehensive Review
This review summarizes the current state of research on micro- and nanoplastics found in air, water, and soil worldwide. These tiny plastic particles pose significant threats to human health including oxidative stress, inflammation, cellular damage, and possible cancer-causing effects, and the authors call for stronger regulations and more research into how they harm the body.
The hidden threat: Microplastics and cancer biology
This review synthesizes current research on the potential links between micro- and nanoplastic exposure and cancer biology, examining how these particles may contribute to tumor development in organs including the gut, lungs, skin, liver, kidney, and brain. The study suggests that chronic exposure to plastic particles can trigger molecular changes such as oxidative stress, inflammation, and DNA damage that are associated with cancer initiation, though clear causal evidence in humans is still lacking.