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61,005 resultsShowing papers similar to Polystyrene and Polyethylene Microplastics Decrease Cell Viability and Dysregulate Inflammatory and Oxidative Stress Markers of MDCK and L929 Cells In Vitro
ClearPro-Inflammatory and Cytotoxic Effects of Polystyrene Microplastics on Human and Murine Intestinal Cell Lines
Researchers tested the effects of polystyrene microplastics on human and mouse intestinal cell lines. They found that microplastic exposure increased cell death and triggered inflammatory responses, including the release of inflammatory signaling molecules. The study suggests that microplastics may promote inflammation in the gut lining, which could have implications for digestive health.
The nephrotoxic potential of polystyrene microplastics at realistic environmental concentrations
Researchers tested polystyrene microplastics on human kidney cells at concentrations reflecting real-world environmental levels. They found that the particles attached to and were engulfed by the cells, triggering oxidative stress and inflammatory responses that reduced cell survival. The findings suggest that even realistic low-level microplastic exposure may pose risks to kidney health.
Cellular response of THP-1 macrophages to polystyrene microplastics exposure
Researchers exposed human macrophage cells to polystyrene nanoparticles smaller than 450 nanometers and observed significant decreases in cell viability, increased oxidative stress, and DNA damage. The particles also reduced mitochondrial membrane potential and inhibited cell proliferation. The findings suggest that microplastic exposure may impair immune cell function in humans, highlighting potential risks to the immune system.
Cytotoxic effect of polystyrene nanoplastics in human umbilical vein endothelial cells (HUVECs) and normal rat kidney cells (NRK52E)
Researchers tested how polystyrene nanoplastics affect human blood vessel cells and rat kidney cells in the lab. They found that nanoplastic exposure caused oxidative stress and reduced cell survival in both cell types, with effects increasing at higher concentrations. The study adds to growing evidence that nanoplastics can damage mammalian cells, though the implications for whole-body health require further investigation.
Micro- and nano-plastics induce inflammation and cell death in human cells.
Human cell cultures exposed to micro- and nano-plastics (MNPLs) showed elevated inflammation markers and cell death, with effects varying by particle type and concentration. The study developed a novel extraction and staining technique to identify individual plastic types in complex mixtures, advancing methods for assessing human cellular toxicity.
An assessment of the toxicity of polypropylene microplastics in human derived cells
Researchers assessed the toxicity of polypropylene microplastics on human-derived cell lines and found that the particles triggered inflammatory responses and oxidative stress at concentrations relevant to environmental exposure. The microplastics also affected cell viability and caused measurable changes in immune-related gene expression. The study raises concerns about potential health effects from chronic human exposure to one of the most commonly produced plastic types.
Dose-Dependent Responses of Escherichia coli and Acinetobacter sp. to Micron-Sized Polystyrene Microplastics
Researchers exposed E. coli and Acinetobacter sp. to 1,040 nm polystyrene microplastics across a range of concentrations and assessed growth, oxidative stress, membrane integrity, and biofilm formation. Both species showed concentration-dependent decreases in growth and cell viability, increased oxidative stress markers, impaired membrane integrity, and enhanced biofilm formation, demonstrating microplastic toxicity to environmental and human-associated bacteria.
The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice
This study found that polystyrene microplastics caused damage to human kidney cells in the lab and accumulated in the kidneys of mice. The microplastics triggered mitochondrial dysfunction, inflammation, and a cellular stress response called autophagy in kidney tissue. These results suggest that long-term microplastic exposure could be a risk factor for kidney disease.
Polystyrene Micro- and Nanoplastic Exposure Triggers an Activation and Stress Response in Human Astrocytes
Researchers exposed primary human astrocytes to polystyrene micro- and nanoplastics and found that these particles triggered cellular stress responses, including increased production of reactive oxygen species and activation of inflammatory pathways. Nanoplastics were particularly effective at penetrating cells and disrupting normal astrocyte function. The findings suggest that plastic particle exposure may contribute to neuroinflammatory processes in the brain, warranting further investigation into potential neurotoxic effects.
Cytotoxic Effects of Microplastics on Human Cells
This study reviewed and tested the cytotoxic effects of microplastics on human cells, finding that microplastic particles can cause cell damage, inflammation, and oxidative stress at relevant concentrations. The results support growing concern that microplastics ingested or inhaled by humans may pose direct health risks at the cellular level.
A review of the toxic effects of microplastics based on studies on mammals and mammalian cell lines
This review examined studies on the toxic effects of microplastics using mammals and mammalian cell experiments. Researchers found that adverse effects in animal studies appeared at relatively low daily doses of polystyrene and polyethylene microplastics. The study notes that cell-based experiments yielded variable results depending on the cell type tested, highlighting the complexity of understanding microplastic health impacts.
Evaluation of toxicity of polystyrene microplastics under realistic exposure levels in human vascular endothelial EA.hy926 cells
Researchers exposed human vascular endothelial cells to polystyrene microplastics at concentrations comparable to levels detected in human blood. They found that the microplastics caused oxidative stress, reduced antioxidant defenses, and triggered apoptosis in the vascular cells. The study suggests that microplastics circulating in the bloodstream at realistic concentrations may contribute to vascular damage by impairing cellular protective mechanisms.
Effects of Microplastics on Cell Viability, Phagocytic Activity and Oxidative Stress in Human Peripheral Blood Mononuclear Cells
Researchers exposed human peripheral blood mononuclear cells (PBMCs) to four concentrations of polyethylene glycol and natural microplastics and measured cell viability, phagocytic activity, and oxidative stress. Higher microplastic concentrations reduced cell viability and phagocytic function while increasing oxidative stress markers, indicating that microplastics impair immune cell performance.
Exposure of microplastic at levels relevant for human health : cytotoxicity and cellular localization of polystyrene microparticles in four human cell lines
Researchers tested the cytotoxicity of polystyrene microplastics on four human cell lines at concentrations relevant to real-world human exposure from food, water, and packaging. At environmentally realistic doses, microplastics were taken up by cells but did not cause significant toxicity, though higher concentrations did produce cell damage, suggesting that current exposure levels may be near a threshold of concern.
Cellular and Systemic Effects of Micro- and Nanoplastics in Mammals—What We Know So Far
This review summarized known cellular and systemic effects of micro- and nanoplastics in mammals, finding that while ingestion is common, knowledge of health impacts remains limited, with oxidative stress and inflammation as the most reported biological responses.
Evaluation of potential toxicity of polyethylene microplastics on human derived cell lines
Researchers tested the toxic effects of two sizes of polyethylene microplastics on human cell lines representing different tissue types. They found that microplastic exposure triggered inflammatory responses and caused cellular damage, with effects varying depending on particle size and cell type. The findings suggest that microplastics commonly encountered in everyday life could pose health risks when they interact with human tissues.
Micro- and nanoplastic induced cellular toxicity in mammals: A review
This review examines research on how micro- and nanoplastics cause cellular damage in mammalian systems, covering both laboratory and animal studies. Evidence indicates that these particles can trigger oxidative stress, inflammation, and DNA damage in cells, with smaller nanoplastics generally showing greater toxicity due to their ability to penetrate cell membranes more readily.
Polystyrene Microplastics of Varying Sizes and Shapes Induce Distinct Redox and Mitochondrial Stress Responses in a Caco-2 Monolayer
Researchers tested three sizes and shapes of polystyrene microplastics on human intestinal cells and found that all were taken up by the cells, with the smallest particles (200 nm) causing the most pronounced effects on cellular stress responses. The microplastics triggered changes in antioxidant gene expression and mitochondrial activity. The study suggests that the number of particles a cell absorbs, driven largely by particle size, determines the severity of the stress response.
Stress Response of Mouse Embryonic Fibroblasts Exposed to Polystyrene Nanoplastics
Mouse embryonic fibroblasts exposed to polystyrene nanoplastics internalized particles via endocytosis without losing viability, but showed activation of antioxidant and autophagic stress pathways, suggesting subcellular dysfunction even in the absence of cell death.
Virgin and Aged Microplastics Induce Type-specific Inflammatory Responses on Vascular Cells
Both virgin and UV-aged polystyrene and polyethylene microplastics triggered inflammatory responses in human coronary artery smooth muscle cells in vitro, with different polymer types and aging states producing distinct patterns of cellular damage. The results suggest that microplastics ingested or inhaled by people may contribute to vascular inflammation and worsen cardiovascular disease — a significant human health concern.
Effects of Polystyrene Microplastics on Human Kidney and Liver Cell Morphology, Cellular Proliferation, and Metabolism
Researchers exposed human kidney and liver cells to polystyrene microplastics of different sizes and concentrations to assess their effects on cell health. They found that microplastics altered cell shape, reduced proliferation, and disrupted cellular metabolism, with smaller particles generally causing more damage. The findings suggest that microplastics reaching internal organs could have measurable effects at the cellular level.
The effects of nanoplastics on adipose stromal cells from swine tissues
Researchers assessed the effects of polystyrene nanoplastics on adipose stromal cells from pig tissue, finding reduced cell viability after prolonged exposure, increased inflammatory marker TNF-alpha, and elevated oxidative stress markers. These results suggest nanoplastics can disrupt cellular redox homeostasis in adipose tissue at environmentally relevant conditions.
Cytotoxicity and pro-inflammatory effect of polystyrene nano-plastic and micro-plastic on RAW264.7 cells.
Researchers found that polystyrene nano-plastics (80 nm) induced apoptosis and pro-inflammatory cytokine release in mouse macrophage RAW264.7 cells at lower concentrations than micro-plastics (3 μm), with nano-plastics also enhancing phagocytic activity and activating NF-kB signaling pathways more potently than their larger counterparts.
Recent consequences of micro-nanaoplastics (MNPLs) in subcellular/molecular environmental pollution toxicity on human and animals
This review examines the subcellular and molecular mechanisms by which micro- and nanoplastics cause toxicity in humans and animals, focusing on oxidative stress, inflammation, cell death pathways, and endocrine disruption at the cellular level.