Back to papers
0
Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Sign in to save

The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice

Environmental Health Perspectives 2021 326 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Yung‐Li Wang, Yu‐Hsuan Lee, Yung‐Ho Hsu, I‐Jen Chiu, Cathy Chia‐Yu Huang, Chih‐Chia Huang, Zi‐Chun Chia, Chung‐Pei Lee, Yuh‐Feng Lin, Hui‐Wen Chiu

Summary

This study found that polystyrene microplastics caused damage to human kidney cells in the lab and accumulated in the kidneys of mice. The microplastics triggered mitochondrial dysfunction, inflammation, and a cellular stress response called autophagy in kidney tissue. These results suggest that long-term microplastic exposure could be a risk factor for kidney disease.

Polymers
PS
Body Systems
Immune Renal
Models
Mouse

The results suggest that PS-MPs caused mitochondrial dysfunction, ER stress, inflammation, and autophagy in kidney cells and accumulated in HK-2 cells and in the kidneys of mice. These results suggest that long-term PS-MPs exposure may be a risk factor for kidney health. https://doi.org/10.1289/EHP7612.

Read via DOI PubMed PMC Full Text Download PDF

Share this paper

Post Share Share Pin Email