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61,005 resultsShowing papers similar to Microplastic consumption induces inflammatory signatures in the colon and prolongs a viral arthritis
ClearMicroplastic consumption induces inflammatory signatures in the colon and prolongs a viral arthritis
Mice that consumed low doses of polystyrene microplastics showed signs of colon inflammation and experienced prolonged viral arthritis symptoms. The results suggest that microplastic ingestion may worsen inflammatory conditions, though more research is needed to confirm human relevance.
Influence of Microplastics on Morphological Manifestations of Experimental Acute Colitis
Researchers fed polystyrene microplastics to mice for six weeks and found that healthy mice developed changes in their colon lining, including altered mucus composition and immune cell populations. When mice with experimentally induced colitis also consumed microplastics, their intestinal inflammation was significantly more severe. The study suggests that microplastic exposure may worsen inflammatory bowel conditions.
Inflammatory response in the mid colon of ICR mice treated with polystyrene microplastics for two weeks
Researchers found that two weeks of oral polystyrene microplastic exposure in ICR mice induced an inflammatory response specifically in the mid colon, suggesting microplastics may contribute to colonic inflammation.
Influence of Microplastics on Manifestations of Experimental Chronic Colitis
Researchers studied whether consuming microplastics worsens chronic colon inflammation in mice. While microplastics alone did not cause visible damage to healthy intestines, they significantly increased the severity of colitis symptoms, including more ulcers and greater inflammatory cell infiltration, in mice with pre-existing colon inflammation. The findings suggest that microplastic exposure may be particularly concerning for individuals who already have inflammatory bowel conditions.
Long-term exposure to polystyrene microplastics reduces macrophages and affects the microbiota–gut–brain axis in mice
Mice that consumed polystyrene microplastics over an extended period showed reduced immune cells called macrophages in their colons and changes in gut bacteria that were linked to altered brain chemistry. This study provides evidence for a gut-brain connection where microplastics may affect brain function indirectly by first disrupting gut health and the immune system.
Polystyrene microplastics induce an immunometabolic active state in macrophages
Researchers found that polystyrene microplastics taken up by macrophages — immune cells lining the gut and lungs — triggered a metabolic shift toward an inflammatory state. This finding suggests microplastics reaching human tissues may alter immune function in ways that could contribute to inflammation-related diseases.
Polystyrene microplastics aggravate inflammatory damage in mice with intestinal immune imbalance
Researchers found that polystyrene microplastics caused significantly worse inflammatory damage in mice that already had compromised intestinal immune systems compared to healthy mice. The microplastics increased inflammatory markers, disrupted gut bacteria, and caused more severe tissue damage in the vulnerable animals. The study suggests that individuals with pre-existing gut health issues may be more susceptible to the harmful effects of microplastic exposure.
Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Researchers induced colitis in mice using dextran sodium sulfate and orally administered polystyrene micro- and nanoplastics of three sizes, then tracked biodistribution, macrophage polarization, and gut microbiome changes. In colitis conditions, microplastic uptake into systemic tissues was enhanced, macrophages shifted toward a pro-inflammatory phenotype, and gut microbial diversity decreased, suggesting that inflammatory bowel disease increases vulnerability to microplastic-driven systemic harm.
Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Researchers exposed colitis mouse models to polystyrene micro- and nanoplastics to test whether MNP exposure worsens inflammatory bowel disease, finding that MNPs altered biodistribution and exacerbated inflammatory responses in animals with pre-existing gut inflammation.
Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Researchers found that polystyrene micro- and nanoplastics aggravated colitis symptoms in a mouse model, increasing gut permeability, inflammatory cytokine levels, and tissue damage compared to controls. The study provides mechanistic evidence linking microplastic exposure to worsening of inflammatory bowel conditions.
Morphological features of the internal organs in mice after prolonged microplastics consumption
Researchers fed mice polystyrene microplastics at three dose levels for four weeks and found dose-dependent morphological changes restricted to the spleen and colon, including inflammatory infiltration and alterations in mucin-secreting goblet cells, while other organs showed no significant pathological changes.
Polystyrene microplastics exacerbate experimental colitis in mice tightly associated with the occurrence of hepatic inflammation
Researchers found that polystyrene microplastics worsened experimentally induced colitis in mice, causing greater intestinal inflammation, reduced mucus secretion, and increased gut permeability. The study also revealed that microplastic exposure in mice with colitis increased the risk of secondary liver inflammation, suggesting that individuals with pre-existing gut conditions may be more vulnerable to microplastic exposure.
Polystyrene microplastics trigger colonic inflammation in rats via the TLR4/NF-κB/COX-2 pathway and modulation of intestinal microbiota
Rats exposed to polystyrene microplastics for 90 days developed significant colon inflammation, including damaged gut lining, increased inflammatory markers, and disrupted gut bacteria. The study identified a specific inflammatory pathway (TLR4/NF-kB/COX-2) through which microplastics trigger intestinal inflammation, providing important clues about how plastic particles in food and water could contribute to gut diseases in humans.
Microplastics cross the murine intestine and induce inflammatory cell death after phagocytosis by human monocytes and neutrophils
Researchers administered polystyrene microplastics orally to mice and then assessed distribution and immune cell interactions in both mice and human cells. Both 1 µm and 10 µm particles crossed the intestinal epithelium and were detected in blood and liver after 10 days, and human monocytes and neutrophils that ingested the particles underwent inflammatory cell death.
Oral exposure to high concentrations of polystyrene microplastics alters the intestinal environment and metabolic outcomes in mice
In a mouse study, oral exposure to high concentrations of polystyrene microplastics caused fatty liver disease and abnormal blood lipid levels even without prior gut leakiness. The microplastics triggered intestinal inflammation through immune cells, disrupted gut bacteria, and altered how the body processes nutrients. These results suggest that swallowing microplastics could contribute to metabolic problems and liver disease in humans.
Polystyrene Microplastics Exacerbate Systemic Inflammation in High-Fat Diet-Induced Obesity
Researchers found that polystyrene microplastics significantly worsened inflammation and metabolic problems in obese mice fed a high-fat diet. The microplastics were found throughout the body including the brain, where they activated immune cells in the hypothalamus, a region that controls appetite and metabolism. This study suggests that microplastic exposure could be an overlooked factor contributing to the worsening of obesity-related health problems like insulin resistance and chronic inflammation.
Prolonged oral ingestion of microplastics induced inflammation in the liver tissues of C57BL/6J mice through polarization of macrophages and increased infiltration of natural killer cells
Researchers found that prolonged oral ingestion of polystyrene microplastics caused liver inflammation in mice by polarizing macrophages and increasing natural killer cell infiltration, revealing how microplastics disrupt the liver immune microenvironment.
Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice
Researchers exposed mice to polystyrene microplastics for six weeks and found that the particles accumulated in the gut, reduced protective mucus secretion, and damaged the intestinal barrier. The microplastics also significantly altered the composition of gut bacteria, decreasing beneficial species and increasing harmful ones. The study suggests that microplastic ingestion could disrupt gut health in mammals by simultaneously impairing the physical barrier and reshaping the microbiome.
Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Researchers studied the effects of polystyrene micro- and nanoplastics in a mouse model of colitis, examining biodistribution, immune cell responses, and gut microbiome changes. The study found that nanosized particles in particular showed distinct biodistribution patterns and affected macrophage polarization under inflammatory conditions, suggesting that intestinal inflammation may alter how the body handles micro- and nanoplastic particles.
Polystyrene nanoplastics induce intestinal and hepatic inflammation through activation of NF-κB/NLRP3 pathways and related gut-liver axis in mice
In a mouse study, ingested polystyrene nanoplastics accumulated in the gut and liver and triggered inflammation through specific immune pathways, damaging the intestinal lining and allowing bacterial toxins to leak into the liver. This gut-liver connection suggests that swallowing nanoplastics could set off a chain reaction of inflammation affecting multiple organs in the body.
Microplastic effects on mouse colon in normal and colitis conditions: A literature review
This literature review examined studies on how microplastic exposure affects the mouse colon under both normal and inflammatory conditions. Evidence indicates that microplastics may contribute to intestinal inflammation and could worsen existing colitis. The review highlights the need for further research to better understand how microplastic ingestion may influence gut health in humans.
Ingestion of micro- and nanoplastic perturbs tissue homeostasis and macrophage core functions
Researchers fed mice polystyrene particles chronically and found that micro- and nanoplastics breached intestinal barriers and accumulated in multiple organs, disrupting tissue homeostasis and impairing core macrophage functions including phagocytosis and inflammatory regulation.
Polystyrene microplastic exposure induces insulin resistance in mice via dysbacteriosis and pro-inflammation
Researchers found that exposing mice to polystyrene microplastics induced insulin resistance regardless of whether the animals were on a normal or high-fat diet. The study identified disruption of gut bacteria and increased intestinal inflammation as key mechanisms driving the metabolic changes. These findings suggest that microplastic exposure may contribute to metabolic health issues by altering the gut microbiome and triggering chronic inflammation.
Proinflammatory properties and lipid disturbance of polystyrene microplastics in the livers of mice with acute colitis
Researchers studied the effects of polystyrene microplastics on the livers of mice fed a high-fat diet and found that the particles triggered significant inflammatory responses and disrupted lipid metabolism. The microplastics worsened fat accumulation in the liver and activated inflammatory signaling pathways. The findings suggest that microplastic exposure combined with a high-fat diet may amplify liver damage and metabolic disturbances.