Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Research Square (Research Square)2024
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Oldamur Hollóczki,
Oldamur Hollóczki,
Oldamur Hollóczki,
Verena Kopatz,
Verena Kopatz,
Verena Kopatz,
Oldamur Hollóczki,
Oldamur Hollóczki,
Verena Kopatz,
Verena Kopatz,
George Sarau,
Oldamur Hollóczki,
Ulrike Resch,
Ulrike Resch,
Vanessa Stadlbauer,
Ulrike Resch,
Verena Pichler,
Verena Pichler,
Verena Pichler,
Verena Pichler,
Oldamur Hollóczki,
Verena Kopatz,
Verena Kopatz,
George Sarau,
George Sarau,
George Sarau,
George Sarau,
George Sarau,
Silke Christiansen,
Kristina Draganić,
Verena Kopatz,
Angela Horvath,
Zeynab Mirzaei,
George Sarau,
Zeynab Mirzaei,
Silke Christiansen,
Oldamur Hollóczki,
Verena Kopatz,
Verena Kopatz,
Zeynab Mirzaei,
Zeynab Mirzaei,
Zeynab Mirzaei,
Zeynab Mirzaei,
Kristina Draganić,
Verena Pichler,
Verena Kopatz,
Oldamur Hollóczki,
Verena Pichler,
Janette Pfneissl,
Janette Pfneissl,
Angela Horvath,
Verena Kopatz,
Verena Kopatz,
Verena Pichler,
Verena Kopatz,
Verena Kopatz,
Verena Kopatz,
Verena Kopatz,
Janette Pfneissl,
Michaela Schlederer,
Michaela Schlederer,
Julijan Kabiljo,
Janette Pfneissl,
Janette Pfneissl,
Janette Pfneissl,
Michaela Schlederer,
Michaela Schlederer,
Silke Christiansen,
Silke Christiansen,
George Sarau,
Silke Christiansen,
Silke Christiansen,
Bernadette Mödl,
Angela Horvath,
George Sarau,
Joachim Widder,
Julijan Kabiljo,
Gerald Timelthaler,
Julia Wallner,
Bernadette Mödl,
Vanessa Stadlbauer,
Vanessa Stadlbauer,
Verena Kopatz,
Verena Kopatz,
Verena Kopatz,
Bernadette Mödl,
Lukas Kenner
Lukas Kenner
Julia Wallner,
Verena Pichler,
Bernadette Mödl,
Oldamur Hollóczki,
Silke Christiansen,
Silke Christiansen,
Gerald Timelthaler,
Gerald Timelthaler,
Julia Wallner,
Gerald Timelthaler,
Julia Wallner,
Verena Pichler,
Oldamur Hollóczki,
Verena Pichler,
Verena Pichler,
Verena Pichler,
Oldamur Hollóczki,
Lukas Kenner
Lukas Kenner
Lukas Kenner
Wolfgang Wadsak,
Silke Christiansen,
Wolfgang Wadsak,
Angela Horvath,
Julia Wallner,
Verena Pichler,
Verena Pichler,
Julia Wallner,
Julia Wallner,
Julia Wallner,
Zeynab Mirzaei,
Silke Christiansen,
Lukas Kenner
Lukas Kenner
Julia Wallner,
Julia Wallner,
Zeynab Mirzaei,
Lukas Kenner
Zeynab Mirzaei,
Oldamur Hollóczki,
Oldamur Hollóczki,
Gerald Timelthaler,
Gerald Timelthaler,
Gerald Timelthaler,
Zeynab Mirzaei,
Zeynab Mirzaei,
Lukas Kenner
Zeynab Mirzaei,
Saule Beratlyte,
Silke Christiansen,
Wolfgang Wadsak,
Saule Beratlyte,
Lukas Kenner
Zeynab Mirzaei,
Zeynab Mirzaei,
Lukas Kenner
Saule Beratlyte,
Michaela Schlederer,
Saule Beratlyte,
Michaela Schlederer,
Saule Beratlyte,
Nikola Zlatkov Kolev,
Wolfgang Wadsak,
Nikola Zlatkov Kolev,
Saule Beratlyte,
Saule Beratlyte,
Saule Beratlyte,
Lukas Kenner
George Sarau,
Verena Kopatz,
Michaela Schlederer,
Michaela Schlederer,
Michaela Schlederer,
Oldamur Hollóczki,
Lukas Kenner
Lukas Kenner
Michaela Schlederer,
Verena Kopatz,
Verena Kopatz,
Oldamur Hollóczki,
Martin Raigel,
Verena Pichler,
Martin Raigel,
Verena Pichler,
George Sarau,
Oldamur Hollóczki,
Joachim Widder,
Ulrike Resch,
Oldamur Hollóczki,
Silke Christiansen,
Oldamur Hollóczki,
Iris Kufferath,
Martin Raigel,
Martin Raigel,
Martin Raigel,
Martin Raigel,
Martin Raigel,
Lukas Kenner
Lukas Kenner
Lukas Kenner
George Sarau,
Wolfgang Wadsak,
Joachim Widder,
Silke Christiansen,
George Sarau,
Iris Kufferath,
Lukas Kenner
Silke Christiansen,
Iris Kufferath,
Iris Kufferath,
Nikola Zlatkov Kolev,
Nikola Zlatkov Kolev,
Wolfgang Wadsak,
Robert Eferl,
Wolfgang Wadsak,
George Sarau,
Gerda Egger,
George Sarau,
Silke Christiansen,
Vanessa Stadlbauer,
Silke Christiansen,
Silke Christiansen,
Nikola Zlatkov Kolev,
Verena Pichler,
Nikola Zlatkov Kolev,
Nikola Zlatkov Kolev,
Nikola Zlatkov Kolev,
Nikola Zlatkov Kolev,
Nikola Zlatkov Kolev,
Lukas Kenner
Robert Eferl,
Robert Eferl,
Robert Eferl,
Gerda Egger,
Vanessa Stadlbauer,
Verena Pichler,
Verena Pichler,
Verena Pichler,
Lukas Kenner
Summary
Researchers found that polystyrene micro- and nanoplastics aggravated colitis symptoms in a mouse model, increasing gut permeability, inflammatory cytokine levels, and tissue damage compared to controls. The study provides mechanistic evidence linking microplastic exposure to worsening of inflammatory bowel conditions.
<title>Abstract</title> Background The increasing prevalence of inflammatory bowel disease (IBD) and rising pollution from micro- and nanoplastic (MNP) particles has prompted investigations on their potential interconnection. To elucidate the complex relationship between IBD and exposure to MNPs, we induced colitis in mice using dextran sodium sulfate (DSS) and orally administered a solution of differently sized polystyrene (PS) MNPs (diameter 10, 1, and 0.29 µm). These particles facilitated a detailed examination of MNP biodistribution, macrophage response, and gut microbiome alterations under inflammatory conditions. Results Specifically nanosized PS particles accumulated in the bloodstream and excretory organs, with enhanced accumulation in the colitis model. Macrophages shifted towards a pro-inflammatory phenotype, with decreased anti-inflammatory markers highlighting the intricate effects of MNPs on inflammation and immune cell behavior. Moreover, MNPs significantly disrupted the gut microbiome, reducing microbial diversity and shifting bacterial populations towards pro-inflammatory and potentially pathogenic species. Conclusions These changes suggest that MNP exposure could exacerbate colitis through complex interactions involving MNPs, immune responses, and microbial dynamics. The fast growing exposure to MNPs underscores the urgent need for comprehensive public health strategies to address MNP pollution, its implications for disease and potential impacts on public health.